Detailed information of TA system TA192591

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): ldrD-rdlD/Ldr(toxin)
• Location: 2476481..2476703
• Replicon: chromosome
• Accession: NZ_CP069996
• Organism: Escherichia coli strain FDAARGOS_1300

Toxin (Protein)

• Gene name: ldrD
• Uniprot ID: A0A0D6GD35
• Locus tag: I6K30_RS12060
• Protein ID: WP_000170745.1
• Coordinates: 2476596..2476703 (+)
• Length: 36 a.a.

Antitoxin (RNA)

Gene name	rdlD
Locus tag	-
Coordinates	2476481..2476539 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
I6K30_RS12040	2471922..2472824	+	903	WP_000084677.1	dipeptide ABC transporter permease DppC	-
I6K30_RS12045	2472835..2473818	+	984	WP_001196477.1	dipeptide ABC transporter ATP-binding protein	-
I6K30_RS12050	2473815..2474819	+	1005	WP_000103579.1	dipeptide ABC transporter ATP-binding subunit DppF	-
I6K30_RS12055	2474849..2476120	-	1272	WP_001332306.1	aromatic amino acid transport family protein	-
-	2476481..2476539	-	59	-	-	Antitoxin
I6K30_RS12060	2476596..2476703	+	108	WP_000170745.1	type I toxin-antitoxin system toxin Ldr family protein	Toxin
I6K30_RS12065	2477078..2477185	+	108	WP_001295224.1	type I toxin-antitoxin system toxin Ldr family protein	-
I6K30_RS12070	2477561..2477668	+	108	WP_001295224.1	type I toxin-antitoxin system toxin Ldr family protein	-
I6K30_RS12075	2477754..2479433	-	1680	WP_000191567.1	cellulose biosynthesis protein BcsG	-
I6K30_RS12080	2479430..2479621	-	192	WP_000988308.1	cellulose biosynthesis protein BcsF	-
I6K30_RS12085	2479618..2481189	-	1572	WP_001204957.1	cellulose biosynthesis c-di-GMP-binding protein BcsE	-
I6K30_RS12090	2481462..2481650	+	189	WP_001063314.1	cellulose biosynthesis protein BcsR	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Type I toxin-antitoxin system, toxin Ldr (1-35)

Sequences

Toxin

Protein

• Length: 36 a.a.
• Molecular weight: 3855.68 Da
• Isoelectric Point: 9.0157

>T192591 WP_000170745.1 NZ_CP069996:2476596-2476703 [Escherichia coli]
MTLAELGMAFWHDLAAPVIAGILASMIVSWLNKRK

Nucleotide

• Length: 108 bp

>T192591 NZ_CP092466:2651993-2652475 [Citrobacter portucalensis]
GTGGGATTTGTAACCGCACCTGAGCCACTAACTCACATTCATCAATTGGCGGAATTTGTCAGCGGAGAAATTGTTCTAGA
TGATTGGTTAAAGCAAAAAGGGTTGAAAAATCAGGCTCTCGGTGCAACCAGGACGTTTGTTGTCTGCAAAACAGACACGC
GACAAGTCGCTGGCTTTTATTCACTGGCCACTGGTAGCGTCAACCACACAGAAGCAACAGGCAATCTTCGGCGTAACATG
CCAGATCCAATCCCCGTAATTATCCTTGCCAGATTGGCCGTAGATCTTTCTGTTCGTGGAAAAGGGTTAGGGGCCGATCT
GCTTCACGATGCGGTACTGCGGTGTTACAAAGTGGCAGAAAATATTGGCGTGCGTGCCGTTATGGTGCATGTGCTCACAG
ACGAAGCTAAACGTTTTTATCTTCACCACGGATTCAAAGCATCTCAACTGCAGGAGCGAACTCTGTTCCTTGGGCTTTCA
TGA

Antitoxin

Nucleotide

• Length: 59 bp

>AT192591 NZ_CP069996:c2476539-2476481 [Escherichia coli]
TCAAGATTAGCCCCCGTGATGTTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTTCTC

Structures

Toxin

• AlphaFold DB: A0A0D6GD35

Antitoxin