192589

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HTH(antitoxin)
Location 2033780..2034382 Replicon chromosome
Accession NZ_CP069996
Organism Escherichia coli strain FDAARGOS_1300

Toxin (Protein)


Gene name higB Uniprot ID S1P416
Locus tag I6K30_RS09930 Protein ID WP_000897302.1
Coordinates 2034071..2034382 (-) Length 104 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag I6K30_RS09925 Protein ID WP_000356397.1
Coordinates 2033780..2034070 (-) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I6K30_RS09900 (2029853) 2029853..2030755 + 903 WP_000331377.1 formate dehydrogenase O subunit beta -
I6K30_RS09905 (2030752) 2030752..2031387 + 636 WP_000829013.1 formate dehydrogenase cytochrome b556 subunit -
I6K30_RS09910 (2031384) 2031384..2032313 + 930 WP_000027720.1 formate dehydrogenase accessory protein FdhE -
I6K30_RS09915 (2032529) 2032529..2032747 - 219 WP_001314326.1 CopG family transcriptional regulator -
I6K30_RS09920 (2033143) 2033143..2033421 - 279 WP_001296612.1 hypothetical protein -
I6K30_RS09925 (2033780) 2033780..2034070 - 291 WP_000356397.1 NadS family protein Antitoxin
I6K30_RS09930 (2034071) 2034071..2034382 - 312 WP_000897302.1 hypothetical protein Toxin
I6K30_RS09935 (2034611) 2034611..2035519 + 909 WP_001331553.1 alpha/beta hydrolase -
I6K30_RS09940 (2035583) 2035583..2036524 - 942 WP_001297068.1 fatty acid biosynthesis protein FabY -
I6K30_RS09945 (2036569) 2036569..2037006 - 438 WP_000560983.1 D-aminoacyl-tRNA deacylase -
I6K30_RS09950 (2037003) 2037003..2037875 - 873 WP_000920762.1 virulence factor BrkB family protein -
I6K30_RS09955 (2037869) 2037869..2038468 - 600 WP_001314324.1 glucose-1-phosphatase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Cro/C1-type helix-turn-helix domain

(36-85)


Sequences

Toxin        


Download         Length: 104 a.a.        Molecular weight: 12203.19 Da        Isoelectric Point: 9.7791

>T192589 WP_000897302.1 NZ_CP069996:c2034382-2034071 [Escherichia coli]
MLFIETEIFTEDVQKLLNDDEFSRFQFFLALNPDYGEVIPETGGLRKVRWVSGGKGKRAGVRVIYFHQVKHYEIRLLLIY
RKGIKDDLSPQEKAMLRLLNTRW

Download         Length: 312 bp

>T192589 NZ_CP092466:2186981-2187084 [Citrobacter portucalensis]
GGCAGGGTAACTTAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATAC
AGGAATCGTATTCGGTCTCTTTTT

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10846.43 Da        Isoelectric Point: 10.8907

>AT192589 WP_000356397.1 NZ_CP069996:c2034070-2033780 [Escherichia coli]
MDKALFERLTHSMAQMNEIIEGTRQPSRTFEVDAMKIKEIRRASGLSQSKFADLISVSVDTLRNWEQGRRSPTGPAKALL
RAIANDPQHVLQALNR

Download         Length: 291 bp

>AT192589 NZ_CP092466:c2187086-2186946 [Citrobacter portucalensis]
ATAAAAAGAGACCGAATACGATTCCTGTATTCGGTCCAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGTTGGC
ATTAATGCAGGCTAAGTTACCCTGCCATTTAAGAATAGATGACAGCGCCAGGTTTTCCAGT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S1P416

Antitoxin

Source ID Structure

References