Detailed information of TA system TA192582

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): symE-rdlD/SymE(toxin)
• Location: 1283870..1284282
• Replicon: chromosome
• Accession: NZ_CP069996
• Organism: Escherichia coli strain FDAARGOS_1300

Toxin (Protein)

• Gene name: symE
• Uniprot ID: A0A8E0IWC4
• Locus tag: I6K30_RS06230
• Protein ID: WP_001513534.1
• Coordinates: 1283941..1284282 (+)
• Length: 114 a.a.

Antitoxin (RNA)

Gene name	rdlD
Locus tag	-
Coordinates	1283870..1283946 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
I6K30_RS06220 (1280482)	1280482..1281951	+	1470	WP_001387312.1	type I restriction-modification system subunit M	-
I6K30_RS06225 (1281951)	1281951..1283720	+	1770	WP_001513535.1	restriction endonuclease subunit S	-
- (1283870)	1283870..1283946	-	77	NuclAT_6	-	Antitoxin
- (1283870)	1283870..1283946	-	77	NuclAT_6	-	Antitoxin
- (1283870)	1283870..1283946	-	77	NuclAT_6	-	Antitoxin
- (1283870)	1283870..1283946	-	77	NuclAT_6	-	Antitoxin
- (1283870)	1283870..1283946	-	77	NuclAT_7	-	Antitoxin
- (1283870)	1283870..1283946	-	77	NuclAT_7	-	Antitoxin
- (1283870)	1283870..1283946	-	77	NuclAT_7	-	Antitoxin
- (1283870)	1283870..1283946	-	77	NuclAT_7	-	Antitoxin
I6K30_RS06230 (1283941)	1283941..1284282	+	342	WP_001513534.1	endoribonuclease SymE	Toxin
I6K30_RS27040 (1284329)	1284329..1285492	-	1164	WP_224153787.1	DUF1524 domain-containing protein	-
I6K30_RS27045 (1285546)	1285546..1286422	-	877	Protein_1225	DUF262 domain-containing protein	-
I6K30_RS06245 (1286828)	1286828..1287748	-	921	WP_001513532.1	Rpn family recombination-promoting nuclease/putative transposase	-
I6K30_RS06250 (1287933)	1287933..1289213	+	1281	WP_001338077.1	DUF445 domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	cheD	1268258..1284282	16024

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin SymE-like (20-71)

Sequences

Toxin

Protein

• Length: 114 a.a.
• Molecular weight: 12247.03 Da
• Isoelectric Point: 7.8545

>T192582 WP_001513534.1 NZ_CP069996:1283941-1284282 [Escherichia coli]
MTDTHSIAQPFEAEVSPANNRQLTVSYASHYPDYSRIPAITLKGQWLEAAGFATGTAVDVKVMEGCIVLTAQPPAAAESE
LMQSLRQVCKLSARKQRQVQEFIGVIAGKQKVA

Nucleotide

• Length: 342 bp

>T192582 NZ_CP092461:1537181-1537483 [Serratia marcescens]
ATTACCGTATATGACAATACGTATCCGGCATCAGCCTATCCCTACTTACTGGACGTTCAAAGCGATCTTATTGATGTCCT
CTCGACCCGGTTAATGATCCCTCTTTATGCTTTGGATAACGTCAGGGTTAAAATTTCTGCACGTTTATGCCCGGAGATTG
AGGTCAACGGCGAAAAGTTTCTTGTTATGACGCATGAGATGGCTGCCGTACGTATTTCGCAGATTGGGAAGGCCGTTGGT
AATGTCAATGAGCACAGGAATCAAATTAAAGCCGCCATCGATTTTCTGATTGATGGTTTTTGA

Antitoxin

Nucleotide

• Length: 77 bp

>AT192582 NZ_CP069996:c1283946-1283870 [Escherichia coli]
AGTCATAACTGCTATTCCCTATAAATAGTGATTGTGATTAGCGGTGCGGGTGTGTTGGCGCACATCCGCACCGCGCT

Structures

Antitoxin