Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) hok-sok/-
Location 1203253..1203511 Replicon chromosome
Accession NZ_CP069996
Organism Escherichia coli strain FDAARGOS_1300

Toxin (Protein)


Gene name hokC Uniprot ID S1NX00
Locus tag I6K30_RS05835 Protein ID WP_000809168.1
Coordinates 1203359..1203511 (+) Length 51 a.a.

Antitoxin (RNA)


Gene name sokC
Locus tag -
Coordinates 1203253..1203310 (-)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I6K30_RS05820 1199085..1200344 - 1260 WP_000494924.1 hypothetical protein -
I6K30_RS05825 1200473..1201966 - 1494 WP_001350775.1 sulfatase-like hydrolase/transferase -
I6K30_RS05830 1201986..1202747 - 762 WP_001274823.1 outer membrane protein OmpK -
- 1203253..1203310 - 58 - - Antitoxin
I6K30_RS05835 1203359..1203511 + 153 WP_000809168.1 type I toxin-antitoxin system toxin MokC Toxin
I6K30_RS05840 1203616..1204746 - 1131 WP_001118464.1 molecular chaperone DnaJ -
I6K30_RS05845 1204835..1206751 - 1917 WP_000516135.1 molecular chaperone DnaK -
I6K30_RS05850 1207123..1207527 + 405 WP_000843687.1 DUF2541 family protein -
I6K30_RS05855 1207553..1208266 + 714 WP_001102393.1 acidic protein MsyB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Hok/gef cell toxic protein

(6-47)


Sequences

Toxin        


Download         Length: 51 a.a.        Molecular weight: 5501.57 Da        Isoelectric Point: 7.1312

>T192580 WP_000809168.1 NZ_CP069996:1203359-1203511 [Escherichia coli]
MKQHKAMIVALIVICITAVVAALVTRKDLCEVHIRTGQTEVAVFTAYESE

Download         Length: 153 bp

>T192580 NZ_CP069996:1203359-1203511 [Escherichia coli]
ATGAAGCAGCATAAGGCGATGATTGTCGCCCTGATCGTCATCTGTATCACCGCCGTAGTGGCGGCGCTGGTAACGAGAAA
AGACCTCTGTGAGGTTCACATCCGAACTGGCCAGACGGAGGTTGCTGTTTTCACGGCTTACGAATCCGAGTAA

Antitoxin


Download         Length: 58 bp

>AT192580 NZ_CP069996:c1203310-1203253 [Escherichia coli]
GTTCTGCATATAGGGGGCCTCGGGTTGATGGTAAAATATCACTCGGGGCTTTTCTCTA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S1NX00

Antitoxin

Download structure file

References