Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) phd-doc/Doc-RelB
Location 4032346..4032932 Replicon chromosome
Accession NZ_CP069994
Organism Klebsiella pneumoniae strain FDAARGOS_1321

Toxin (Protein)


Gene name doc Uniprot ID W8VD46
Locus tag I6K51_RS19630 Protein ID WP_002920800.1
Coordinates 4032346..4032714 (-) Length 123 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID W9B1V1
Locus tag I6K51_RS19635 Protein ID WP_004174006.1
Coordinates 4032711..4032932 (-) Length 74 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I6K51_RS19610 4027849..4028919 - 1071 WP_004150074.1 sn-glycerol-3-phosphate import ATP-binding protein UgpC -
I6K51_RS19615 4028921..4029766 - 846 WP_004174009.1 sn-glycerol-3-phosphate ABC transporter permease UgpE -
I6K51_RS19620 4029763..4030650 - 888 WP_002920792.1 sn-glycerol-3-phosphate ABC transporter permease UgpA -
I6K51_RS19625 4030757..4032073 - 1317 WP_002920796.1 sn-glycerol-3-phosphate ABC transporter substrate-binding protein UgpB -
I6K51_RS19630 4032346..4032714 - 369 WP_002920800.1 type II toxin-antitoxin system death-on-curing family toxin Toxin
I6K51_RS19635 4032711..4032932 - 222 WP_004174006.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
I6K51_RS19640 4033096..4033809 - 714 WP_009484078.1 high-affinity branched-chain amino acid ABC transporter ATP-binding protein LivF -
I6K51_RS19645 4033811..4034578 - 768 WP_002920803.1 high-affinity branched-chain amino acid ABC transporter ATP-binding protein LivG -
I6K51_RS19650 4034575..4035852 - 1278 WP_004174005.1 branched chain amino acid ABC transporter permease LivM -
I6K51_RS19655 4035849..4036775 - 927 WP_002920807.1 high-affinity branched-chain amino acid ABC transporter permease LivH -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Prophage - - 4026768..4035852 9084


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Fido domain

(13-86)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-50)


Sequences

Toxin        


Download         Length: 123 a.a.        Molecular weight: 13552.92 Da        Isoelectric Point: 8.6410

>T192571 WP_002920800.1 NZ_CP069994:c4032714-4032346 [Klebsiella pneumoniae]
MTLQIISAEEIIQFHDRLLRVTPGVAGMPDPGRAEAIMYRVLNKIEYEGVTDVWRLAAMHLLAISRGHIFNDGNKRTALF
ITLLFLKRNGIILPANPDFVGMTVEAAAGQLTLEQIVARLRG

Download         Length: 369 bp

>T192571 NZ_CP092460:424376-424951 [Dickeya fangzhongdai]
ATGACCCATACACCTTATCCTGTCGTGCTAGATGCGTGCGTAATTTATCCATCTCTCCTGCGGGATTTATTAATCCACTT
AGGACTAACAGGGCTGTATCAGCCTAAGTGGACGGCCATCATCGAGGATGAATGGCAACGCAATCTACTGCTGAATAGAC
CTGATTTAACCCCGGAGCAAATCTCGCGGACACGCGAGCTGATGAATCAGGCTATTCCTGATGCGATGATTACTGGGTTT
GAAGCGCTCATTCCAGGCATCACGCTCCCTGATCCTGATGATCAGCATGTGGTTGCAGCCGCCATTCGCAGTAACGCTGA
AATCATCGTTACGTTTAACCTGAAAGATTTTCCCCATCCCGAGATCGATAACTTTGGCATTGAAGCGCTACACCCGGATG
ATTTCATCACAGACCTGCTCGATTTGAATCAGGCGCTTGTGTTATCCGCAGTAAGCAGGCAGCGTCACAGCATGAGAAAA
CCGCCTAAATCGGTTGATGAGTATCTTGATGCGTTACTCCGGCAGAGCTTACCGCAAACAGTAAAAGAATTGAGTAAATT
CCACACCCTGATTTAG

Antitoxin


Download         Length: 74 a.a.        Molecular weight: 8151.15 Da        Isoelectric Point: 4.7769

>AT192571 WP_004174006.1 NZ_CP069994:c4032932-4032711 [Klebsiella pneumoniae]
MRTVNYSEARQNLADVLESAVTGVPVTITRRGHKSAVIISAEEFERYQAARMDDEFAAIMAVHGDEIRELADK

Download         Length: 222 bp

>AT192571 NZ_CP092460:423915-424376 [Dickeya fangzhongdai]
ATGACAAACTCAATTCTTGATAGCCTGAGCCTTCCGGCACCAGGGGAGATTGAGGCGGCTGTTCGTGGACAAAGGGAGCT
TGCTGCCTATCTCTCCACAAAGATGGAAACACAAAAAATCTCGATTCAGGACGCAGATAACAACACTCGTCAGGTCGAAT
TACCGACGTCGGCACTGACATTATTGATGTCGATTTTAGGCGAGCTGGCTGTGGGTAACGCGGTTCAGGTTGTTCCTGTT
CATGCTGAATTAACGACACAGGAGGCAGCCAACATTCTGAATGTTTCACGCCCTCACATGGTGAAGCTTCTGGAGGATGG
GAAACTACCTTTTCATAAAACCGGTCGCCACCGCCGTGTGCTTTTCGCTGACCTGATGGACTATAAACACCAGAGGGATA
ATGAAAGCAGTAGAGCAATGCAGGCGTTGGCAGATCATAGCCAAGAGCTTGGATTGTACTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GUD1

Antitoxin

Source ID Structure
AlphaFold DB A0A5E5YJY7

References