Detailed information of TA system TA192474

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): hok-sok/-
• Location: 2774601..2774859
• Replicon: chromosome
• Accession: NZ_CP069980
• Organism: Escherichia coli strain FDAARGOS_1291

Toxin (Protein)

• Gene name: hokC
• Uniprot ID: S1NX00
• Locus tag: I6K21_RS12895
• Protein ID: WP_000809168.1
• Coordinates: 2774601..2774753 (-)
• Length: 51 a.a.

Antitoxin (RNA)

Gene name	sokC
Locus tag	-
Coordinates	2774802..2774859 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
I6K21_RS12875	2769843..2770556	-	714	WP_001102367.1	acidic protein MsyB	-
I6K21_RS12880	2770582..2770986	-	405	WP_000843584.1	DUF2541 family protein	-
I6K21_RS12885	2771362..2773278	+	1917	WP_000516135.1	molecular chaperone DnaK	-
I6K21_RS12890	2773367..2774497	+	1131	WP_001118464.1	molecular chaperone DnaJ	-
I6K21_RS12895	2774601..2774753	-	153	WP_000809168.1	type I toxin-antitoxin system toxin MokC	Toxin
-	2774802..2774859	+	58	-	-	Antitoxin
I6K21_RS12900	2775339..2776505	+	1167	WP_000681360.1	Na+/H+ antiporter NhaA	-
I6K21_RS12905	2776571..2777470	+	900	WP_001300855.1	transcriptional activator NhaR	-
I6K21_RS12910	2777508..2778467	-	960	WP_000871674.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Hok/gef cell toxic protein (6-47)

Sequences

Toxin

Protein

• Length: 51 a.a.
• Molecular weight: 5501.57 Da
• Isoelectric Point: 7.1312

>T192474 WP_000809168.1 NZ_CP069980:c2774753-2774601 [Escherichia coli]
MKQHKAMIVALIVICITAVVAALVTRKDLCEVHIRTGQTEVAVFTAYESE

Nucleotide

• Length: 153 bp

>T192474 NZ_CP092417:6819267-6819521 [Endozoicomonas sp. SCSIO W0465]
ATGAATGTGGTTTCCTACACAGAAATGAGAAAAAACCTCAAAGCGGTTCTGGACAGCGTTGTTAATGATGCAACCCACAC
CGTCATTCACCGGCGTGACGCAGAAGATGCGGTAGTTATGTCGAAAGAAAGTTACGACAGCCTGATGGAAACGCTGTATC
TGCTCTCGTCACCTGAAAATGCCCGTCGGTTGAAATCCGCCGCTGAACAATTCAAAGCTAATAAGGGCATTAAAAGGGAT
CTGCCTGAATTATGA

Antitoxin

Nucleotide

• Length: 58 bp

>AT192474 NZ_CP069980:2774802-2774859 [Escherichia coli]
GTTCAGCATATAGGGGGCCTCGGGTTGATGGTAAAATATCACTCGGGGCTTTTCTCTA

Structures

Toxin

• AlphaFold DB: S1NX00

Antitoxin