Detailed information of TA system TA192470

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): symER/SymE(toxin)
• Location: 2682654..2683066
• Replicon: chromosome
• Accession: NZ_CP069980
• Organism: Escherichia coli strain FDAARGOS_1291

Toxin (Protein)

• Gene name: symE
• Uniprot ID: U9YSY7
• Locus tag: I6K21_RS12445
• Protein ID: WP_000132601.1
• Coordinates: 2682654..2682995 (-)
• Length: 114 a.a.

Antitoxin (RNA)

Gene name	symR
Locus tag	-
Coordinates	2682990..2683066 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
I6K21_RS12435 (2680067)	2680067..2681113	-	1047	WP_000437621.1	5-methylcytosine-specific restriction endonuclease system specificity protein McrC	-
I6K21_RS12440 (2681113)	2681113..2682492	-	1380	WP_000443951.1	5-methylcytosine-specific restriction endonuclease subunit McrB	-
I6K21_RS12445 (2682654)	2682654..2682995	-	342	WP_000132601.1	endoribonuclease SymE	Toxin
- (2682990)	2682990..2683066	+	77	NuclAT_12	-	Antitoxin
- (2682990)	2682990..2683066	+	77	NuclAT_12	-	Antitoxin
- (2682990)	2682990..2683066	+	77	NuclAT_12	-	Antitoxin
- (2682990)	2682990..2683066	+	77	NuclAT_12	-	Antitoxin
- (2682990)	2682990..2683066	+	77	NuclAT_13	-	Antitoxin
- (2682990)	2682990..2683066	+	77	NuclAT_13	-	Antitoxin
- (2682990)	2682990..2683066	+	77	NuclAT_13	-	Antitoxin
- (2682990)	2682990..2683066	+	77	NuclAT_13	-	Antitoxin
I6K21_RS12450 (2683223)	2683223..2684617	-	1395	WP_001272445.1	type I restriction-modification system specificity subunit	-
I6K21_RS12455 (2684614)	2684614..2686203	-	1590	WP_001063200.1	type I restriction-modification system methyltransferase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	2670363..2684617	14254

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin SymE-like (20-71)

Sequences

Toxin

Protein

• Length: 114 a.a.
• Molecular weight: 12203.02 Da
• Isoelectric Point: 8.5012

>T192470 WP_000132601.1 NZ_CP069980:c2682995-2682654 [Escherichia coli]
MTDTHSIAQPFEAEVSPANNRHVTVGYASRYPDYSRIPAITLKGQWLEAAGFATGTAVDVKVMEGCIVLTAQPPAAEESE
LMQSLRQVCKLSARKQKQVQAFIGVIAGKQKVA

Nucleotide

• Length: 342 bp

>T192470 NZ_CP092417:3640775-3641116 [Endozoicomonas sp. SCSIO W0465]
TTGAGCGTTTATGAACGTGGCGATATTGTCAGAGTGAATTTAAACCCGGTGTCAGGATCAGAAGTACAAGGAGAGAGCCG
ACCTTGCCTTGTACTTTCTGTAAAAGCATTTAACTGCCTTGGCTCTACGCTGGTTGCTCCGATTACTCAGGGAGGTAATT
ATGCCCGTGTACAGGGTTTTACTGTTCCATTGATGGGAACGGGAACAGAGACTCAGGGAGTAGTGCTCATTAATGGCGTG
AGGATGATTGACCTCAGGGCCAGGCAATCAAGGAAGGTTGAGAGTGCCCCCGAAGCACTGGTTAATGAAGTCCTGGCAAA
GCTTCAAGCCATCATTGAATAG

Antitoxin

Nucleotide

• Length: 77 bp

>AT192470 NZ_CP069980:2682990-2683066 [Escherichia coli]
AGTCATAACTGCTATTCTCCAGGAATAGTGATTGTGATTAGCGATGCGGGTGTGTTGGCGCACATCCGCACCGCGCT

Structures

Toxin

• AlphaFold DB: U9YSY7

Antitoxin