Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mqsRA (relBE)/MqsR-MqsA
Location 1194915..1195608 Replicon chromosome
Accession NZ_CP069980
Organism Escherichia coli strain FDAARGOS_1291

Toxin (Protein)


Gene name mqsR Uniprot ID S1EZG2
Locus tag I6K21_RS05415 Protein ID WP_000415584.1
Coordinates 1195312..1195608 (-) Length 99 a.a.

Antitoxin (Protein)


Gene name mqsA Uniprot ID S1EBV2
Locus tag I6K21_RS05410 Protein ID WP_000650107.1
Coordinates 1194915..1195310 (-) Length 132 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I6K21_RS05400 (1190779) 1190779..1193037 - 2259 WP_001281841.1 DNA topoisomerase IV subunit A -
I6K21_RS05405 (1193175) 1193175..1194782 - 1608 WP_001735743.1 ABC transporter substrate-binding protein -
I6K21_RS05410 (1194915) 1194915..1195310 - 396 WP_000650107.1 type II toxin-antitoxin system antitoxin MqsA Antitoxin
I6K21_RS05415 (1195312) 1195312..1195608 - 297 WP_000415584.1 type II toxin-antitoxin system toxin MqsR Toxin
I6K21_RS05420 (1195813) 1195813..1196295 - 483 WP_000183505.1 GyrI-like domain-containing protein -
I6K21_RS05425 (1196348) 1196348..1196740 - 393 WP_000712658.1 OB fold stress tolerance protein YgiW -
I6K21_RS05430 (1196892) 1196892..1197551 + 660 WP_001221510.1 quorum sensing response regulator transcription factor QseB -
I6K21_RS05435 (1197548) 1197548..1198897 + 1350 WP_000673402.1 quorum sensing histidine kinase QseC -
I6K21_RS05440 (1198943) 1198943..1199275 - 333 WP_000917684.1 DUF2645 family protein -
I6K21_RS05445 (1199594) 1199594..1200175 + 582 WP_000072421.1 NADPH:quinone oxidoreductase MdaB -
I6K21_RS05450 (1200206) 1200206..1200520 + 315 WP_000958598.1 putative quinol monooxygenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase toxin MqsR

(5-97)

Antitoxin

Zinc finger, MqsA-type

(3-47)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 11231.96 Da        Isoelectric Point: 8.9070

>T192464 WP_000415584.1 NZ_CP069980:c1195608-1195312 [Escherichia coli]
MEKRTPHTRLSQVKKLVNAGQVRTTRSALLNADELGLDFDGMCNVIIGLSESDFYKSMTTYSDHTIWQDVYRPRLVTGQV
YLKITVIHDVLIVSFKEK

Download         Length: 297 bp

>T192464 NZ_CP092417:1051445-1051714 [Endozoicomonas sp. SCSIO W0465]
ATGACCAGTAAACAGAGGCATCTCTGTTGGTCACACAACGCCTGGAACGATTATCTGTACTGGCAGGAACAGGACAGAAA
AACCTTGAAACGCATCAACAAATTAATCACTGAGTGTCTGCGGGACCCGTTTAGCGGCCTTGGCAAGCCCGAACCTCTGA
AAGGCAATTGGCAAGGCTTCTGGTCAAGACGCATCAGCGATGAACACCGACTGATCTACCAGCCTTCCGATACTCATCTG
ACCATTGCCGCCTGTCGTTTCCATTACTAG

Antitoxin


Download         Length: 132 a.a.        Molecular weight: 14703.10 Da        Isoelectric Point: 9.2136

>AT192464 WP_000650107.1 NZ_CP069980:c1195310-1194915 [Escherichia coli]
MKCPVCHQGEMVSGIKDIPYTFRGRKTVLKGIHGLYCVHCEESIMNKEESDAFMAQVKAFRASVNAETVAPEFIVKVRKK
LSLTQKEASEIFGGGVNAFSRYEKGNAQPHPSTIKLLRVLDKHPELLNEIR

Download         Length: 396 bp

>AT192464 NZ_CP092417:1051198-1051455 [Endozoicomonas sp. SCSIO W0465]
ATGAAAGTAGTCTCTTACTCTGAAGCCCGGAACAACTTGAAGTCACTGCTTGACCAGGTGGCGGAAGACGCCAGTGAAAC
CATCATTCATCGTCGTGACGGTCAGGATGCCGTGCTCATGTCACTGGCAAGCTACAACAGCCTGATGGAAACCCTGCATC
TGATGTCATCCCCTGCCAACGCCAAACACTTGAACGACTCCATTGAACAAATCAGGGGCGGTCAGATCGTTGACAAGGGC
CTGCTCGATGACCAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 3HI2

Antitoxin

Source ID Structure
PDB 3HI2
PDB 3GA8
PDB 3O9X
PDB 2KZ8
PDB 3FMY
PDB 3GN5
AlphaFold DB A0A7U9LU65

References