Detailed information of TA system TA192426

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): hok-sok/-
• Location: 92478..92718
• Replicon: plasmid unnamed4
• Accession: NZ_CP069974
• Organism: Escherichia coli strain FDAARGOS_1280

Toxin (Protein)

• Gene name: hok
• Uniprot ID: -
• Locus tag: I6K10_RS26330
• Protein ID: WP_001372321.1
• Coordinates: 92478..92603 (-)
• Length: 42 a.a.

Antitoxin (RNA)

Gene name	sok
Locus tag	-
Coordinates	92680..92718 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
I6K10_RS26310 (87986)	87986..88807	-	822	WP_001234469.1	DUF932 domain-containing protein	-
I6K10_RS26315 (88926)	88926..89213	-	288	WP_000107535.1	hypothetical protein	-
I6K10_RS26320 (89238)	89238..89444	-	207	WP_024190427.1	hypothetical protein	-
I6K10_RS27175 (89514)	89514..89687	+	174	Protein_120	hypothetical protein	-
I6K10_RS26325 (90416)	90416..92083	+	1668	WP_052991863.1	group II intron reverse transcriptase/maturase	-
I6K10_RS26330 (92478)	92478..92603	-	126	WP_001372321.1	type I toxin-antitoxin system Hok family toxin	Toxin
I6K10_RS27180 (92545)	92545..92694	-	150	Protein_123	plasmid maintenance protein Mok	-
- (92680)	92680..92718	-	39	NuclAT_1	-	Antitoxin
- (92680)	92680..92718	-	39	NuclAT_1	-	Antitoxin
- (92680)	92680..92718	-	39	NuclAT_1	-	Antitoxin
- (92680)	92680..92718	-	39	NuclAT_1	-	Antitoxin
- (94158)	94158..94260	-	103	NuclAT_0	-	-
- (94158)	94158..94260	-	103	NuclAT_0	-	-
- (94158)	94158..94260	-	103	NuclAT_0	-	-
- (94158)	94158..94260	-	103	NuclAT_0	-	-
I6K10_RS26340 (94229)	94229..94991	-	763	Protein_125	plasmid SOS inhibition protein A	-
I6K10_RS26345 (94988)	94988..95422	-	435	WP_000845940.1	conjugation system SOS inhibitor PsiB	-
I6K10_RS26350 (95477)	95477..97435	-	1959	WP_000117179.1	ParB/RepB/Spo0J family partition protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Mobilizable plasmid	tet(B) / dfrA17 / aadA5 / qacE / sul1 / blaTEM-1B / blaCTX-M-15 / qnrS1 / erm(B) / mph(A) / aac(3)-IId	-	1..136429	136429

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Hok/gef cell toxic protein (2-37)

Sequences

Toxin

Protein

• Length: 42 a.a.
• Molecular weight: 4780.69 Da
• Isoelectric Point: 8.5110

>T192426 WP_001372321.1 NZ_CP069974:c92603-92478 [Escherichia coli]
VLIVCLTLLIFTYLTRKSLCEIRYRDGHREVAAFMAYESGK

Nucleotide

• Length: 126 bp

>T192426 NZ_CP092382:655466-655618 [Xanthomonas oryzae]
ATGAAGCGACTGCTGACACTGATGGTGCTGGGCCTGTTTTCGGCCGGCGTGATGACGGGCTGCAACACCGTGGCTGGCGC
TGGCAAGGACTTGCAGGGCGCGGGTGGGAAGGTCGAGAAAACGGCCGAAAAATGCAGCGATGGTAAGTGCTGA

Antitoxin

Nucleotide

• Length: 39 bp

>AT192426 NZ_CP069974:c92718-92680 [Escherichia coli]
CATTAACCACCACGAGGCATCCCTATGTCTAGTCCACAT

Structures

Antitoxin