Detailed information of TA system TA192407

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): ralRA/-
• Location: 3595166..3595537
• Replicon: chromosome
• Accession: NZ_CP069973
• Organism: Escherichia coli strain FDAARGOS_1280

Toxin (Protein)

• Gene name: ralR
• Uniprot ID: A0A0D6ZRD3
• Locus tag: I6K10_RS18100
• Protein ID: WP_001443846.1
• Coordinates: 3595388..3595537 (-)
• Length: 50 a.a.

Antitoxin (RNA)

Gene name	ralA
Locus tag	-
Coordinates	3595166..3595344 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
I6K10_RS27300 (3590918)	3590918..3591091	+	174	WP_001296046.1	protein YnaL	-
I6K10_RS18075 (3591121)	3591121..3592494	+	1374	WP_000123748.1	ATP-dependent RNA helicase DbpA	-
I6K10_RS18080 (3592623)	3592623..3593558	-	936	WP_001523172.1	tRNA 2-thiocytidine(32) synthetase TtcA	-
I6K10_RS18085 (3593610)	3593610..3594845	-	1236	WP_000040839.1	site-specific integrase	-
I6K10_RS18090 (3594847)	3594847..3595062	-	216	WP_000079604.1	excisionase XisR	-
- (3595166)	3595166..3595344	+	179	NuclAT_0	-	Antitoxin
- (3595166)	3595166..3595344	+	179	NuclAT_0	-	Antitoxin
- (3595166)	3595166..3595344	+	179	NuclAT_0	-	Antitoxin
- (3595166)	3595166..3595344	+	179	NuclAT_0	-	Antitoxin
I6K10_RS18095 (3595162)	3595162..3595350	-	189	WP_001302840.1	DUF1187 family protein	-
I6K10_RS18100 (3595388)	3595388..3595537	-	150	WP_001443846.1	type I toxin-antitoxin system endodeoxyribonuclease toxin RalR	Toxin
I6K10_RS18105 (3595593)	3595593..3596402	-	810	WP_000166313.1	recombination protein RecT	-
I6K10_RS18110 (3596395)	3596395..3598995	-	2601	WP_000105140.1	exodeoxyribonuclease VIII	-
I6K10_RS18115 (3599097)	3599097..3599372	-	276	WP_001344816.1	hypothetical protein	-
I6K10_RS18120 (3599447)	3599447..3599617	-	171	WP_001352098.1	YdaE family protein	-
I6K10_RS18125 (3599617)	3599617..3599838	-	222	WP_000560223.1	killing protein KilR	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	3593610..3644037	50427

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Endodeoxyribonuclease toxin RalR (6-48)

Sequences

Toxin

Protein

• Length: 50 a.a.
• Molecular weight: 5383.12 Da
• Isoelectric Point: 8.3398

>T192407 WP_001443846.1 NZ_CP069973:c3595537-3595388 [Escherichia coli]
MRYDNVKPCPFCGCPSVTVKAISGYYRAKCNGCESRTGYGGSEKEALER

Nucleotide

• Length: 150 bp

>T192407 NZ_CP092379:701499-702422 [Xanthomonas oryzae]
ATGAACGAACCTGACAAGAGCAGGCGCACTGTTGCCGCGTCGGTTCGCGCCCGGCTGCTCAACAAGGCCCGCGCCGAAAG
ACTCGACTTCAACCTGCTGCTGACCCGCTACGCGCTGGAGCGCGTCCTTTACCGCCTGAGCGTTTCGGAGCAGCAGGGTC
AATTCTTGCTCAAAGGTGCGCTGCTGTTCGACATCTGGTTCGACATACCGCATCGCCCGACGCACGATGCCGACCTGCTG
GGCTTCGGCTCCACCGAGATCCCACATCTGGAAGACCTGTTCCGCAGAATCAGTCAAATCGCCAGCGATGACGGCATCGT
GTTTCAGGCCGACAGCGTGAAGGCCGCCGAAATCCGCAAGGAGGCCAACTACGCGGGCGTCCGTGTGACGATGATCGGCC
TGCTCGATGGCGCGCGCTGCACGGTGCAGATCGACATCGGTTTCGGCGACGCCGTGACGCCCGGCCCGGACAACGTGCAG
TACCCAGTCATCCTCGACGGCATGCCGCAGCCGCAACTGCGGGTCTATCCCCGCTACACCGTGGTCGCCGAAAAGCTGGA
AGCGATGGTCAAGCTCGGCATCCTCAACAGCCGGATGAAGGACTACTTCGACCTCTGGGTTCTCGCCGGACATTCCGACT
TCGACGGTGCGGTGCTGGCCACGGCCATTCGCGCCACGTTCGAGTGCAGGGGTACGGCCATCCCACCCGGCGCGCCGCTG
GGCCTCACCGATGAGTTCGGCCTGGACGAGCAGAAGACAAAGCAGTGGCAGGCGTTCCTGCGCAAGAACACCTTGGAGCC
GATGCCGCTGACCACGGTGATCGAAGCGCTGCGCGAATTCGTGCTGCCCGTGCTGGCCGCGCTCGCGGCAGGCGAAGGTT
TCGACCGCCAGTGGCGCGCGGGCGCGGGATGGGATGCGGCCTGA

Antitoxin

Nucleotide

• Length: 179 bp

>AT192407 NZ_CP069973:3595166-3595344 [Escherichia coli]
GAGGACTGAAGTTTCTCGCAATTAAAATTTATCAGTTTTACTTTCTGCTCTCTGGAAACGCCTGCTTCTTTTTTACCTGA
GAGCATTTTTTCGCATTCTGATTTCGTTAGTTTAGATTTTGAATATCTTGTCCAGTTAGTAGGAGTGCCACCTTCCTTTT
CAATAGTGGCGGTAATTTT

Structures

Toxin

• AlphaFold DB: A0A0D6ZRD3

Antitoxin