Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | mqsRA (relBE)/MqsR-MqsA |
Location | 440280..440973 | Replicon | chromosome |
Accession | NZ_CP069973 | ||
Organism | Escherichia coli strain FDAARGOS_1280 |
Toxin (Protein)
Gene name | mqsR | Uniprot ID | S1EZG2 |
Locus tag | I6K10_RS03090 | Protein ID | WP_000415584.1 |
Coordinates | 440677..440973 (-) | Length | 99 a.a. |
Antitoxin (Protein)
Gene name | mqsA | Uniprot ID | S1EBV2 |
Locus tag | I6K10_RS03085 | Protein ID | WP_000650107.1 |
Coordinates | 440280..440675 (-) | Length | 132 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
I6K10_RS03075 (436144) | 436144..438402 | - | 2259 | WP_001281841.1 | DNA topoisomerase IV subunit A | - |
I6K10_RS03080 (438540) | 438540..440147 | - | 1608 | WP_001295629.1 | ABC transporter substrate-binding protein | - |
I6K10_RS03085 (440280) | 440280..440675 | - | 396 | WP_000650107.1 | type II toxin-antitoxin system antitoxin MqsA | Antitoxin |
I6K10_RS03090 (440677) | 440677..440973 | - | 297 | WP_000415584.1 | type II toxin-antitoxin system toxin MqsR | Toxin |
I6K10_RS03095 (441178) | 441178..441660 | - | 483 | WP_000183505.1 | GyrI-like domain-containing protein | - |
I6K10_RS03100 (441713) | 441713..442105 | - | 393 | WP_000712658.1 | OB fold stress tolerance protein YgiW | - |
I6K10_RS03105 (442257) | 442257..442916 | + | 660 | WP_001221493.1 | quorum sensing response regulator transcription factor QseB | - |
I6K10_RS03110 (442913) | 442913..444262 | + | 1350 | WP_000673402.1 | quorum sensing histidine kinase QseC | - |
I6K10_RS03115 (444308) | 444308..444640 | - | 333 | WP_023149630.1 | DUF2645 family protein | - |
I6K10_RS03120 (444959) | 444959..445540 | + | 582 | WP_000065430.1 | NADPH:quinone oxidoreductase MdaB | - |
I6K10_RS03125 (445571) | 445571..445885 | + | 315 | WP_000958598.1 | putative quinol monooxygenase | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
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Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 99 a.a. Molecular weight: 11231.96 Da Isoelectric Point: 8.9070
>T192392 WP_000415584.1 NZ_CP069973:c440973-440677 [Escherichia coli]
MEKRTPHTRLSQVKKLVNAGQVRTTRSALLNADELGLDFDGMCNVIIGLSESDFYKSMTTYSDHTIWQDVYRPRLVTGQV
YLKITVIHDVLIVSFKEK
MEKRTPHTRLSQVKKLVNAGQVRTTRSALLNADELGLDFDGMCNVIIGLSESDFYKSMTTYSDHTIWQDVYRPRLVTGQV
YLKITVIHDVLIVSFKEK
Download Length: 297 bp
>T192392 NZ_CP092369:c2185143-2184967 [Bacillus subtilis]
GTGCTTGAGAAAGTGGGTATTATAGTTGCTTTCCTCATATCTTTAACGGTTCTTACAATCAACAGTCTAACAATAGTTGA
GAAGATAAGAAATCTAAAGAATGGGACAAGCAAAAAGAAAAAGCGTATACGCAAGCGGCTCCGACCAAAGAGACAACGCC
AACATATACGCCGATGA
GTGCTTGAGAAAGTGGGTATTATAGTTGCTTTCCTCATATCTTTAACGGTTCTTACAATCAACAGTCTAACAATAGTTGA
GAAGATAAGAAATCTAAAGAATGGGACAAGCAAAAAGAAAAAGCGTATACGCAAGCGGCTCCGACCAAAGAGACAACGCC
AACATATACGCCGATGA
Antitoxin
Download Length: 132 a.a. Molecular weight: 14703.10 Da Isoelectric Point: 9.2136
>AT192392 WP_000650107.1 NZ_CP069973:c440675-440280 [Escherichia coli]
MKCPVCHQGEMVSGIKDIPYTFRGRKTVLKGIHGLYCVHCEESIMNKEESDAFMAQVKAFRASVNAETVAPEFIVKVRKK
LSLTQKEASEIFGGGVNAFSRYEKGNAQPHPSTIKLLRVLDKHPELLNEIR
MKCPVCHQGEMVSGIKDIPYTFRGRKTVLKGIHGLYCVHCEESIMNKEESDAFMAQVKAFRASVNAETVAPEFIVKVRKK
LSLTQKEASEIFGGGVNAFSRYEKGNAQPHPSTIKLLRVLDKHPELLNEIR
Download Length: 396 bp
>AT192392 NZ_CP092369:2185084-2185184 [Bacillus subtilis]
GATTGTAAGAACCGTTAAAGATATGAGGAAAGCAACTATAATACCCACTTTCTCAAGCACTATGTACACCTCCTTTCCTA
TGACTCTATTATAACATAATT
GATTGTAAGAACCGTTAAAGATATGAGGAAAGCAACTATAATACCCACTTTCTCAAGCACTATGTACACCTCCTTTCCTA
TGACTCTATTATAACATAATT
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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