Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mqsRA (relBE)/MqsR-MqsA
Location 440280..440973 Replicon chromosome
Accession NZ_CP069973
Organism Escherichia coli strain FDAARGOS_1280

Toxin (Protein)


Gene name mqsR Uniprot ID S1EZG2
Locus tag I6K10_RS03090 Protein ID WP_000415584.1
Coordinates 440677..440973 (-) Length 99 a.a.

Antitoxin (Protein)


Gene name mqsA Uniprot ID S1EBV2
Locus tag I6K10_RS03085 Protein ID WP_000650107.1
Coordinates 440280..440675 (-) Length 132 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I6K10_RS03075 (436144) 436144..438402 - 2259 WP_001281841.1 DNA topoisomerase IV subunit A -
I6K10_RS03080 (438540) 438540..440147 - 1608 WP_001295629.1 ABC transporter substrate-binding protein -
I6K10_RS03085 (440280) 440280..440675 - 396 WP_000650107.1 type II toxin-antitoxin system antitoxin MqsA Antitoxin
I6K10_RS03090 (440677) 440677..440973 - 297 WP_000415584.1 type II toxin-antitoxin system toxin MqsR Toxin
I6K10_RS03095 (441178) 441178..441660 - 483 WP_000183505.1 GyrI-like domain-containing protein -
I6K10_RS03100 (441713) 441713..442105 - 393 WP_000712658.1 OB fold stress tolerance protein YgiW -
I6K10_RS03105 (442257) 442257..442916 + 660 WP_001221493.1 quorum sensing response regulator transcription factor QseB -
I6K10_RS03110 (442913) 442913..444262 + 1350 WP_000673402.1 quorum sensing histidine kinase QseC -
I6K10_RS03115 (444308) 444308..444640 - 333 WP_023149630.1 DUF2645 family protein -
I6K10_RS03120 (444959) 444959..445540 + 582 WP_000065430.1 NADPH:quinone oxidoreductase MdaB -
I6K10_RS03125 (445571) 445571..445885 + 315 WP_000958598.1 putative quinol monooxygenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase toxin MqsR

(5-97)

Antitoxin

Zinc finger, MqsA-type

(3-47)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 11231.96 Da        Isoelectric Point: 8.9070

>T192392 WP_000415584.1 NZ_CP069973:c440973-440677 [Escherichia coli]
MEKRTPHTRLSQVKKLVNAGQVRTTRSALLNADELGLDFDGMCNVIIGLSESDFYKSMTTYSDHTIWQDVYRPRLVTGQV
YLKITVIHDVLIVSFKEK

Download         Length: 297 bp

>T192392 NZ_CP092369:c2185143-2184967 [Bacillus subtilis]
GTGCTTGAGAAAGTGGGTATTATAGTTGCTTTCCTCATATCTTTAACGGTTCTTACAATCAACAGTCTAACAATAGTTGA
GAAGATAAGAAATCTAAAGAATGGGACAAGCAAAAAGAAAAAGCGTATACGCAAGCGGCTCCGACCAAAGAGACAACGCC
AACATATACGCCGATGA

Antitoxin


Download         Length: 132 a.a.        Molecular weight: 14703.10 Da        Isoelectric Point: 9.2136

>AT192392 WP_000650107.1 NZ_CP069973:c440675-440280 [Escherichia coli]
MKCPVCHQGEMVSGIKDIPYTFRGRKTVLKGIHGLYCVHCEESIMNKEESDAFMAQVKAFRASVNAETVAPEFIVKVRKK
LSLTQKEASEIFGGGVNAFSRYEKGNAQPHPSTIKLLRVLDKHPELLNEIR

Download         Length: 396 bp

>AT192392 NZ_CP092369:2185084-2185184 [Bacillus subtilis]
GATTGTAAGAACCGTTAAAGATATGAGGAAAGCAACTATAATACCCACTTTCTCAAGCACTATGTACACCTCCTTTCCTA
TGACTCTATTATAACATAATT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 3HI2

Antitoxin

Source ID Structure
PDB 3HI2
PDB 3GA8
PDB 3O9X
PDB 2KZ8
PDB 3FMY
PDB 3GN5
AlphaFold DB A0A7U9LU65

References