Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) phd-doc/Doc-RelB
Location 4309828..4310414 Replicon chromosome
Accession NZ_CP069968
Organism Klebsiella pneumoniae strain FDAARGOS_1308

Toxin (Protein)


Gene name doc Uniprot ID W8VD46
Locus tag I6K38_RS20950 Protein ID WP_002920800.1
Coordinates 4310046..4310414 (+) Length 123 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID W9B1V1
Locus tag I6K38_RS20945 Protein ID WP_004174006.1
Coordinates 4309828..4310049 (+) Length 74 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I6K38_RS20925 4305985..4306911 + 927 WP_002920807.1 high-affinity branched-chain amino acid ABC transporter permease LivH -
I6K38_RS20930 4306908..4308185 + 1278 WP_004174005.1 branched chain amino acid ABC transporter permease LivM -
I6K38_RS20935 4308182..4308949 + 768 WP_002920803.1 high-affinity branched-chain amino acid ABC transporter ATP-binding protein LivG -
I6K38_RS20940 4308951..4309664 + 714 WP_004145133.1 high-affinity branched-chain amino acid ABC transporter ATP-binding protein LivF -
I6K38_RS20945 4309828..4310049 + 222 WP_004174006.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
I6K38_RS20950 4310046..4310414 + 369 WP_002920800.1 type II toxin-antitoxin system death-on-curing family toxin Toxin
I6K38_RS20955 4310687..4312003 + 1317 WP_004174008.1 sn-glycerol-3-phosphate ABC transporter substrate-binding protein UgpB -
I6K38_RS20960 4312110..4312997 + 888 WP_002920792.1 sn-glycerol-3-phosphate ABC transporter permease UgpA -
I6K38_RS20965 4312994..4313839 + 846 WP_004181473.1 sn-glycerol-3-phosphate ABC transporter permease UgpE -
I6K38_RS20970 4313841..4314911 + 1071 WP_004150074.1 sn-glycerol-3-phosphate import ATP-binding protein UgpC -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Prophage - - 4306908..4315648 8740


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Fido domain

(13-86)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-50)


Sequences

Toxin        


Download         Length: 123 a.a.        Molecular weight: 13552.92 Da        Isoelectric Point: 8.6410

>T192377 WP_002920800.1 NZ_CP069968:4310046-4310414 [Klebsiella pneumoniae]
MTLQIISAEEIIQFHDRLLRVTPGVAGMPDPGRAEAIMYRVLNKIEYEGVTDVWRLAAMHLLAISRGHIFNDGNKRTALF
ITLLFLKRNGIILPANPDFVGMTVEAAAGQLTLEQIVARLRG

Download         Length: 369 bp

>T192377 NZ_CP092361:1618728-1619120 [Wielerella bovis]
ATGAAATATTTGTTGGATACCAATATCATCATCGCTTTTCAAAAACAACATCAAGGCTTGTTGGCACAAATGAAAAAGCA
TTCGGTCAATGATTTTGCATTGTCCAACATTGTGTTATTTGAATTGGCATTTGGAGCATACAACAGCCAAAAGGTTGATG
AAAATTTGCATAAATTAAGCCAATTACGCTTTCCCACCCTGACATTTAACAGTCAAGACGCTTATCACGCAGGCAAAATT
CGGGCAAACTTACAAAAACAAGGCACACCAATCGGTGCGTATGATACGCTGATTGCAGGTCAAGCCATTGCCCAAAATTT
GATTTTAATTACCCATAATATCAAAGAATTTGAACGGGTTGAAGGGTTAAGGTCTGAAAATTGGTTGATGTAG

Antitoxin


Download         Length: 74 a.a.        Molecular weight: 8151.15 Da        Isoelectric Point: 4.7769

>AT192377 WP_004174006.1 NZ_CP069968:4309828-4310049 [Klebsiella pneumoniae]
MRTVNYSEARQNLADVLESAVTGVPVTITRRGHKSAVIISAEEFERYQAARMDDEFAAIMAVHGDEIRELADK

Download         Length: 222 bp

>AT192377 NZ_CP092361:1618489-1618731 [Wielerella bovis]
ATGACTACCGCAAAATTATTTTGGACAGGCAATTCCCAAGCCGTGCGATTGCCCAAAGAGTTTCGTTTTGAAGGCAAAGA
AGTTCGCATTTTTAAACACGGCAATCAAGTGATTATTGAGCCGATTGCCGATGACTGGGGCTGGGTCAATGAGTTAGAAC
CTTTTGATGACACAATGGAACAAGCCATTTTGGAGCTAAAAAATGATGTGCCACAAGAGCGAGATTGGAGCGTTTTTGAA
TGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GUD1

Antitoxin

Source ID Structure
AlphaFold DB A0A5E5YJY7

References