Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 2637657..2638303 Replicon chromosome
Accession NZ_CP069961
Organism Klebsiella pneumoniae strain FDAARGOS_1317

Toxin (Protein)


Gene name higB Uniprot ID A0A486RBU5
Locus tag I6K47_RS12675 Protein ID WP_032410616.1
Coordinates 2637657..2638004 (+) Length 116 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID W8UB68
Locus tag I6K47_RS12680 Protein ID WP_002920557.1
Coordinates 2638004..2638303 (+) Length 100 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I6K47_RS12665 2633583..2635016 + 1434 WP_002920564.1 glycogen synthase GlgA -
I6K47_RS12670 2635034..2637481 + 2448 WP_002920561.1 glycogen phosphorylase -
I6K47_RS12675 2637657..2638004 + 348 WP_032410616.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
I6K47_RS12680 2638004..2638303 + 300 WP_002920557.1 helix-turn-helix transcriptional regulator Antitoxin
I6K47_RS12685 2638366..2639874 - 1509 WP_002920554.1 glycerol-3-phosphate dehydrogenase -
I6K47_RS12690 2640079..2640408 + 330 WP_002920552.1 thiosulfate sulfurtransferase GlpE -
I6K47_RS12695 2640459..2641289 + 831 WP_004151408.1 rhomboid family intramembrane serine protease GlpG -
I6K47_RS12700 2641339..2642097 + 759 WP_002920548.1 DeoR/GlpR family transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(13-107)

Antitoxin

HigA2-like, helix-turn-helix domain

(9-87)


Sequences

Toxin        


Download         Length: 116 a.a.        Molecular weight: 13545.55 Da        Isoelectric Point: 5.6802

>T192328 WP_032410616.1 NZ_CP069961:2637657-2638004 [Klebsiella pneumoniae]
MWDVETTDTFDTWFELQSRALKEDMLATILILSEFAPQLGRPYVDTVKDSTFQNMKELRVQHHGLPIRAFFAFEPLRKAI
VLCAGDKDGMNEKRFYKEMITLADREFSQHLTKER

Download         Length: 348 bp

>T192328 NZ_CP092289:c1920207-1919929 [Marinobacter sp. M1C]
ATGATTCGAAGCTTCAAACACAAGGGCTTGGCCAAATTCTTCAAGTCCGGCAGCATCGCAGGGATTCAGGCCGCTCACGC
CAAGAGGCTTCGGCTTATTCTCGGTAGATTAAATGCAGCCTCAGATGCCAAAGATATGGACCTGCCAGGCCTTCGGTTGC
ACGAACTCTCCGGTAATCGCGCCGGAATCTGGTCAGTGATGGTCAGTGGCAACTGGCGAGTGACGTTCCGATTTGAGGAC
GGAGATGCCGAGATCGTAAATTATGAAGATTACCATTGA

Antitoxin


Download         Length: 100 a.a.        Molecular weight: 10800.58 Da        Isoelectric Point: 10.1464

>AT192328 WP_002920557.1 NZ_CP069961:2638004-2638303 [Klebsiella pneumoniae]
MATLKELMAKQSPDSQQRIAAKAAEIRQSVALNLLREELQMSQTEMAAAMGVKQPTIAKMEQADNDPRLSTLKRYIAALG
GELSINVTLPTGKKVSFNL

Download         Length: 300 bp

>AT192328 NZ_CP092289:c1919918-1919631 [Marinobacter sp. M1C]
ATGTTGATGCATAACCCCCCCCACCCTGGTGAAGTACTGCGAGAGCTTTGTCTGGAGCCCCTGAACCTATCGGTCACGGC
GGCCGCAGAGGCATTGGGTGTTAGTCGTAAGACTTTGAGCGCCGTGCTGAACGGCAAGGCTGGTATTAGTCCCGAAATGG
CTATCCGGCTTTCTATAGCATTCGACACTTCGGCAGAGAGCTGGCTAAACCAGCAGTCCCAATATGAGCTCTGGCATGCT
GAACAACATCGCAAAGAGCTCAAGGTGAAGAAGCTTGTTGCGGCCTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A486RBU5

Antitoxin

Source ID Structure
AlphaFold DB A0A0E1CBF8

References