Detailed information of TA system
Overview
TA module
| Type | I | Classification (family/domain) | hok-sok/- |
| Location | 65929..66193 | Replicon | plasmid unnamed1 |
| Accession | NZ_CP069958 | ||
| Organism | Escherichia coli strain FDAARGOS_1279 | ||
Toxin (Protein)
| Gene name | pndA | Uniprot ID | U9Y6M3 |
| Locus tag | I6K09_RS24750 | Protein ID | WP_001331364.1 |
| Coordinates | 66041..66193 (+) | Length | 51 a.a. |
Antitoxin (RNA)
| Gene name | pndB | ||
| Locus tag | - | ||
| Coordinates | 65929..65986 (-) |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| I6K09_RS24735 (61168) | 61168..63459 | - | 2292 | WP_001289276.1 | F-type conjugative transfer protein TrbC | - |
| I6K09_RS24740 (63452) | 63452..64522 | - | 1071 | WP_000151583.1 | IncI1-type conjugal transfer protein TrbB | - |
| I6K09_RS24745 (64541) | 64541..65749 | - | 1209 | WP_000121274.1 | IncI1-type conjugal transfer protein TrbA | - |
| - (65929) | 65929..65986 | - | 58 | NuclAT_0 | - | Antitoxin |
| - (65929) | 65929..65986 | - | 58 | NuclAT_0 | - | Antitoxin |
| - (65929) | 65929..65986 | - | 58 | NuclAT_0 | - | Antitoxin |
| - (65929) | 65929..65986 | - | 58 | NuclAT_0 | - | Antitoxin |
| I6K09_RS24750 (66041) | 66041..66193 | + | 153 | WP_001331364.1 | Hok/Gef family protein | Toxin |
| I6K09_RS26155 (67017) | 67017..67112 | + | 96 | WP_000609148.1 | DinQ-like type I toxin DqlB | - |
| I6K09_RS24760 (67177) | 67177..67353 | - | 177 | WP_001054904.1 | hypothetical protein | - |
| I6K09_RS24765 (67745) | 67745..67954 | + | 210 | WP_000062603.1 | HEAT repeat domain-containing protein | - |
| I6K09_RS24770 (68026) | 68026..68688 | - | 663 | WP_000653334.1 | plasmid IncI1-type surface exclusion protein ExcA | - |
| I6K09_RS24775 (68753) | 68753..70750 | - | 1998 | Protein_81 | DotA/TraY family protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Conjugative plasmid | mph(A) | - | 1..94581 | 94581 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 51 a.a. Molecular weight: 5775.13 Da Isoelectric Point: 8.7948
>T192310 WP_001331364.1 NZ_CP069958:66041-66193 [Escherichia coli]
MPQRTFLMMLIVICVTILCFVWMVRDSLCGLRLQQGNTVLVATLAYEVKR
MPQRTFLMMLIVICVTILCFVWMVRDSLCGLRLQQGNTVLVATLAYEVKR
Download Length: 153 bp
>T192310 NZ_CP092288:c2823317-2822922 [Marinobacter sp. M2C]
GTGATACGTATTTTCAAGTCAGTCACGATCCAAAAACTGTTCAAAGAACAGGATTTAGACGATCTCATCAACGACTTTCG
AAAGTACAAGGAAAGTGGTCTTTGCCCGGATTACTTTGGGCGGGATGTCGCCTATGATCACCCGCATACTCCATCGCTAA
TTCTGCAGGAAGATGTGCGTCACGTTCATTTATCAGAATTCGGCGCCTGGCCGGTTCGGCTAATGCAATTTAATCGCACG
AGTGATCGGCACCTGGTTTATTGTCAAGGTGCCATCCACAGGGAGTGTTACCTGCTCATCACACTTCTGAGCCCTGATGC
CCATGAGCAAGCCACCGTTAGCAACGTCATGCGCAAAATTGGAGAGCAAGCTGAAATTTTTCGAATGAAGTATTAA
GTGATACGTATTTTCAAGTCAGTCACGATCCAAAAACTGTTCAAAGAACAGGATTTAGACGATCTCATCAACGACTTTCG
AAAGTACAAGGAAAGTGGTCTTTGCCCGGATTACTTTGGGCGGGATGTCGCCTATGATCACCCGCATACTCCATCGCTAA
TTCTGCAGGAAGATGTGCGTCACGTTCATTTATCAGAATTCGGCGCCTGGCCGGTTCGGCTAATGCAATTTAATCGCACG
AGTGATCGGCACCTGGTTTATTGTCAAGGTGCCATCCACAGGGAGTGTTACCTGCTCATCACACTTCTGAGCCCTGATGC
CCATGAGCAAGCCACCGTTAGCAACGTCATGCGCAAAATTGGAGAGCAAGCTGAAATTTTTCGAATGAAGTATTAA
Antitoxin
Download Length: 58 bp
>AT192310 NZ_CP069958:c65986-65929 [Escherichia coli]
GCATTACAGTAGAGCCCTTGGTTGATTGATAAAAAAATCTCCAGGGGCTTTCTGCTGT
GCATTACAGTAGAGCCCTTGGTTGATTGATAAAAAAATCTCCAGGGGCTTTCTGCTGT
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
