Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mqsRA (relBE)/MqsR-MqsA
Location 4075391..4076084 Replicon chromosome
Accession NZ_CP069957
Organism Escherichia coli strain FDAARGOS_1279

Toxin (Protein)


Gene name mqsR Uniprot ID S1EZG2
Locus tag I6K09_RS19525 Protein ID WP_000415584.1
Coordinates 4075391..4075687 (+) Length 99 a.a.

Antitoxin (Protein)


Gene name mqsA Uniprot ID S1EBV2
Locus tag I6K09_RS19530 Protein ID WP_000650107.1
Coordinates 4075689..4076084 (+) Length 132 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I6K09_RS19495 (4070890) 4070890..4071405 - 516 Protein_3839 NADPH:quinone oxidoreductase MdaB -
I6K09_RS19500 (4071724) 4071724..4072056 + 333 WP_023149630.1 DUF2645 family protein -
I6K09_RS19505 (4072102) 4072102..4073451 - 1350 WP_000673402.1 quorum sensing histidine kinase QseC -
I6K09_RS19510 (4073448) 4073448..4074107 - 660 WP_001221493.1 quorum sensing response regulator transcription factor QseB -
I6K09_RS19515 (4074259) 4074259..4074651 + 393 WP_000712658.1 OB fold stress tolerance protein YgiW -
I6K09_RS19520 (4074704) 4074704..4075186 + 483 WP_000183505.1 GyrI-like domain-containing protein -
I6K09_RS19525 (4075391) 4075391..4075687 + 297 WP_000415584.1 type II toxin-antitoxin system toxin MqsR Toxin
I6K09_RS19530 (4075689) 4075689..4076084 + 396 WP_000650107.1 type II toxin-antitoxin system antitoxin MqsA Antitoxin
I6K09_RS19535 (4076217) 4076217..4077824 + 1608 WP_001295629.1 ABC transporter substrate-binding protein -
I6K09_RS19540 (4077962) 4077962..4080220 + 2259 WP_001281841.1 DNA topoisomerase IV subunit A -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase toxin MqsR

(5-97)

Antitoxin

Zinc finger, MqsA-type

(3-47)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 11231.96 Da        Isoelectric Point: 8.9070

>T192304 WP_000415584.1 NZ_CP069957:4075391-4075687 [Escherichia coli]
MEKRTPHTRLSQVKKLVNAGQVRTTRSALLNADELGLDFDGMCNVIIGLSESDFYKSMTTYSDHTIWQDVYRPRLVTGQV
YLKITVIHDVLIVSFKEK

Download         Length: 297 bp

>T192304 NZ_CP092288:c1047012-1046740 [Marinobacter sp. M2C]
GTGCTAACGCCAGTGCAATCGACCCAGTTCAAAAAAGACGTGAAGAAAGCCCGCAAGCGGGGCAAAGACTTGGACAAACT
AAAGATGTCGCTCAGTTTGCTGATTCGCCAGGCACCGTTACCCGAAGCTTATCAAGATCATCCTTTACGGGGGAACTGGA
AGGGCTATCGAGACGCGCATATTGAGCCGGACTGGTTGCTTTTGTACCGAGTGACCGACAAGGAATTGCAGTTAGCCCGA
ACCGGAACGCACGCGGATTTGTTTCAGGAGTAG

Antitoxin


Download         Length: 132 a.a.        Molecular weight: 14703.10 Da        Isoelectric Point: 9.2136

>AT192304 WP_000650107.1 NZ_CP069957:4075689-4076084 [Escherichia coli]
MKCPVCHQGEMVSGIKDIPYTFRGRKTVLKGIHGLYCVHCEESIMNKEESDAFMAQVKAFRASVNAETVAPEFIVKVRKK
LSLTQKEASEIFGGGVNAFSRYEKGNAQPHPSTIKLLRVLDKHPELLNEIR

Download         Length: 396 bp

>AT192304 NZ_CP092288:c1047269-1047012 [Marinobacter sp. M2C]
ATGAATACCGATTCTGTAGTTCGTGCCCGCATCGACAGTGACACCAAAGCCCGCGCCACCGCCGCGCTGGACGCCATGGG
CCTGTCCGTTTCAGACGCCATACGCTTGCTCATGCTCAAGATTGCTGACGAACAGCGATTGCCGTTTGCGGTGCAAGTGC
CCAATGCCAAAACGGTCAAGGCCATGGAAGAGCTGGAAGCTGGCAAGGGCAAGCGTTTCAGTCACGAACAGGCGCTGTTT
GACGATCTGGGGTTGTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 3HI2

Antitoxin

Source ID Structure
PDB 3HI2
PDB 3GA8
PDB 3O9X
PDB 2KZ8
PDB 3FMY
PDB 3GN5
AlphaFold DB A0A7U9LU65

References