Detailed information of TA system TA192224

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): hok-sok/-
• Location: 799839..800097
• Replicon: chromosome
• Accession: NZ_CP069945
• Organism: Escherichia coli strain FDAARGOS_1373

Toxin (Protein)

• Gene name: hokC
• Uniprot ID: S1NX00
• Locus tag: I6L03_RS03720
• Protein ID: WP_000809168.1
• Coordinates: 799839..799991 (-)
• Length: 51 a.a.

Antitoxin (RNA)

Gene name	sokC
Locus tag	-
Coordinates	800040..800097 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
I6L03_RS03700	795084..795797	-	714	WP_001102393.1	acidic protein MsyB	-
I6L03_RS03705	795823..796227	-	405	WP_001765391.1	DUF2541 family protein	-
I6L03_RS03710	796599..798515	+	1917	WP_000516135.1	molecular chaperone DnaK	-
I6L03_RS03715	798604..799734	+	1131	WP_001118464.1	molecular chaperone DnaJ	-
I6L03_RS03720	799839..799991	-	153	WP_000809168.1	type I toxin-antitoxin system toxin MokC	Toxin
-	800040..800097	+	58	-	-	Antitoxin
I6L03_RS03725	800606..801367	+	762	WP_001274832.1	outer membrane protein OmpK	-
I6L03_RS03730	801387..802880	+	1494	WP_001443162.1	sulfatase-like hydrolase/transferase	-
I6L03_RS03735	803009..804268	+	1260	WP_000494928.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Hok/gef cell toxic protein (6-47)

Sequences

Toxin

Protein

• Length: 51 a.a.
• Molecular weight: 5501.57 Da
• Isoelectric Point: 7.1312

>T192224 WP_000809168.1 NZ_CP069945:c799991-799839 [Escherichia coli]
MKQHKAMIVALIVICITAVVAALVTRKDLCEVHIRTGQTEVAVFTAYESE

Nucleotide

• Length: 153 bp

>T192224 NZ_CP092201:54100-54441 [Leptospira weilii]
TTGGTAAAGAGTAGGAAATATACTCCTGAAAAAGGAGATATAGTTTGGCTGAACTTTACCCCGCAAGCAGGTCATGAACA
AAAAGGTCGTAGACCAGCTTTAGTTTTGTCACCTAAAGAATATAATTCGAAAACTGGATTAGCAATTTTCTGTCCGATTA
CTAGTAAGATTAAAGGTTATCCATTCGAGGTAACAATTAAATTGAAGAAAATTGATGGTGTAATTCTTTCTGATCAAGTG
AAAAACTTAGACTGGACTATTCGTGAAGCTGAATTTATAGAATCAATAAATAAAGTTTCTTTGAAAGAAGTTTTAGATAA
TATTAAGTTATTAGTATTTTAA

Antitoxin

Nucleotide

• Length: 58 bp

>AT192224 NZ_CP069945:800040-800097 [Escherichia coli]
GTTCTGCATATAGGGGGCCTCGGGTTGATGGTAAAATATCACTCGGGGCTTTTCTCTA

Structures

Toxin

• AlphaFold DB: S1NX00

Antitoxin