Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | higBA (relBE)/COG4683-HTH_37 |
Location | 1079383..1080033 | Replicon | chromosome |
Accession | NZ_CP069943 | ||
Organism | Klebsiella oxytoca strain FDAARGOS_1332 |
Toxin (Protein)
Gene name | higB | Uniprot ID | - |
Locus tag | I6K62_RS04975 | Protein ID | WP_049128706.1 |
Coordinates | 1079383..1079724 (+) | Length | 114 a.a. |
Antitoxin (Protein)
Gene name | higA | Uniprot ID | - |
Locus tag | I6K62_RS04980 | Protein ID | WP_017145203.1 |
Coordinates | 1079734..1080033 (+) | Length | 100 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
I6K62_RS04960 | 1075645..1076964 | + | 1320 | WP_004107101.1 | MFS transporter | - |
I6K62_RS04965 | 1077110..1078501 | + | 1392 | WP_004107098.1 | hexose-6-phosphate:phosphate antiporter | - |
I6K62_RS04970 | 1078679..1079131 | + | 453 | WP_004116616.1 | DUF1198 domain-containing protein | - |
I6K62_RS04975 | 1079383..1079724 | + | 342 | WP_049128706.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
I6K62_RS04980 | 1079734..1080033 | + | 300 | WP_017145203.1 | helix-turn-helix transcriptional regulator | Antitoxin |
I6K62_RS04985 | 1080152..1081333 | + | 1182 | WP_017145204.1 | purine ribonucleoside efflux pump NepI | - |
I6K62_RS04990 | 1081365..1082174 | - | 810 | WP_032729158.1 | phosphonoacetaldehyde hydrolase | - |
I6K62_RS04995 | 1082184..1083287 | - | 1104 | WP_049593719.1 | 2-aminoethylphosphonate--pyruvate transaminase | - |
I6K62_RS05000 | 1083428..1084147 | + | 720 | WP_004107085.1 | phosphonate utilization transcriptional regulator PhnR | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
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Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 114 a.a. Molecular weight: 13064.90 Da Isoelectric Point: 5.7456
>T192208 WP_049128706.1 NZ_CP069943:1079383-1079724 [Klebsiella oxytoca]
MWNVETTEVFDKWFEAQTEALKEDMLAAMVILSEYGPQLGRPFADTVNDSAFSNMKELRVQHQGSPIRAFFVFDPSRRGI
LLCAGDKTGLNEKRFYKDMIKLADAEYRKHLNQ
MWNVETTEVFDKWFEAQTEALKEDMLAAMVILSEYGPQLGRPFADTVNDSAFSNMKELRVQHQGSPIRAFFVFDPSRRGI
LLCAGDKTGLNEKRFYKDMIKLADAEYRKHLNQ
Download Length: 342 bp
>T192208 NZ_CP092184:c1387440-1387150 [Serratia marcescens]
ATGAAGATTATTTATACCACCGAAGAGTTCGACAGCTGGTTTACCGGCCTTCGCGACAGGCAAGCCCAGAAGCGCATTCA
GACCCGTATCGACCGTGCGGAAGGTGGAAATTTTGGCGACTGCGAACCTGTTGGCGAAGGCGTGTCAGAAATGCGAATTC
ATTACGGCCCCGGCTATCGAGTGTATTTCGTGCAGCAAGGCATGGAGATTGTGATTTTGCTAGCCGGTGGCGATAAGTCC
ACCCAATCCAAAGATATTAAAGCTGCGCTTGAACTCGCGCGACAGCTATAG
ATGAAGATTATTTATACCACCGAAGAGTTCGACAGCTGGTTTACCGGCCTTCGCGACAGGCAAGCCCAGAAGCGCATTCA
GACCCGTATCGACCGTGCGGAAGGTGGAAATTTTGGCGACTGCGAACCTGTTGGCGAAGGCGTGTCAGAAATGCGAATTC
ATTACGGCCCCGGCTATCGAGTGTATTTCGTGCAGCAAGGCATGGAGATTGTGATTTTGCTAGCCGGTGGCGATAAGTCC
ACCCAATCCAAAGATATTAAAGCTGCGCTTGAACTCGCGCGACAGCTATAG
Antitoxin
Download Length: 100 a.a. Molecular weight: 10874.80 Da Isoelectric Point: 10.0948
>AT192208 WP_017145203.1 NZ_CP069943:1079734-1080033 [Klebsiella oxytoca]
MATLKELMAKQSPESQARIAEKVEAMRQVIALSMLREELNLSQAELAKAMGVKQPTIAKMEQADNDPRLSTLKRYVAALG
GELSIDVKLPGGKRIAFHL
MATLKELMAKQSPESQARIAEKVEAMRQVIALSMLREELNLSQAELAKAMGVKQPTIAKMEQADNDPRLSTLKRYVAALG
GELSIDVKLPGGKRIAFHL
Download Length: 300 bp
>AT192208 NZ_CP092184:c1387140-1386847 [Serratia marcescens]
ATGGGAACTCTAAAACTACGTAAATGGGATAGCGCCGAGCACCTCAACAGTGATGAGGACATCGTTGCCTATCTGGAAGC
CTGCATGGAAGAAGCCGGTGACGATGCAGCTTTCATTGCCAAGGCATTGGGAAACATCGCCCGCGCTCGCGGCATGACTC
AACTCGCCAAGGAAACAGGCGTAGGCCGCGAAAGCCTATACAAAGCGTTGTCAGGAGAGGGTAACCCGAGTTTCGGCACA
ATCCTGAAAGTCATGCATGCTCTCGGGTTACGCCTACACACTACGGCTGCCTGA
ATGGGAACTCTAAAACTACGTAAATGGGATAGCGCCGAGCACCTCAACAGTGATGAGGACATCGTTGCCTATCTGGAAGC
CTGCATGGAAGAAGCCGGTGACGATGCAGCTTTCATTGCCAAGGCATTGGGAAACATCGCCCGCGCTCGCGGCATGACTC
AACTCGCCAAGGAAACAGGCGTAGGCCGCGAAAGCCTATACAAAGCGTTGTCAGGAGAGGGTAACCCGAGTTTCGGCACA
ATCCTGAAAGTCATGCATGCTCTCGGGTTACGCCTACACACTACGGCTGCCTGA
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Structures
Toxin
Source | ID | Structure |
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Antitoxin
Source | ID | Structure |
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