Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 1079383..1080033 Replicon chromosome
Accession NZ_CP069943
Organism Klebsiella oxytoca strain FDAARGOS_1332

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag I6K62_RS04975 Protein ID WP_049128706.1
Coordinates 1079383..1079724 (+) Length 114 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag I6K62_RS04980 Protein ID WP_017145203.1
Coordinates 1079734..1080033 (+) Length 100 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I6K62_RS04960 1075645..1076964 + 1320 WP_004107101.1 MFS transporter -
I6K62_RS04965 1077110..1078501 + 1392 WP_004107098.1 hexose-6-phosphate:phosphate antiporter -
I6K62_RS04970 1078679..1079131 + 453 WP_004116616.1 DUF1198 domain-containing protein -
I6K62_RS04975 1079383..1079724 + 342 WP_049128706.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
I6K62_RS04980 1079734..1080033 + 300 WP_017145203.1 helix-turn-helix transcriptional regulator Antitoxin
I6K62_RS04985 1080152..1081333 + 1182 WP_017145204.1 purine ribonucleoside efflux pump NepI -
I6K62_RS04990 1081365..1082174 - 810 WP_032729158.1 phosphonoacetaldehyde hydrolase -
I6K62_RS04995 1082184..1083287 - 1104 WP_049593719.1 2-aminoethylphosphonate--pyruvate transaminase -
I6K62_RS05000 1083428..1084147 + 720 WP_004107085.1 phosphonate utilization transcriptional regulator PhnR -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(12-107)

Antitoxin

HigA2-like, helix-turn-helix domain

(8-88)


Sequences

Toxin        


Download         Length: 114 a.a.        Molecular weight: 13064.90 Da        Isoelectric Point: 5.7456

>T192208 WP_049128706.1 NZ_CP069943:1079383-1079724 [Klebsiella oxytoca]
MWNVETTEVFDKWFEAQTEALKEDMLAAMVILSEYGPQLGRPFADTVNDSAFSNMKELRVQHQGSPIRAFFVFDPSRRGI
LLCAGDKTGLNEKRFYKDMIKLADAEYRKHLNQ

Download         Length: 342 bp

>T192208 NZ_CP092184:c1387440-1387150 [Serratia marcescens]
ATGAAGATTATTTATACCACCGAAGAGTTCGACAGCTGGTTTACCGGCCTTCGCGACAGGCAAGCCCAGAAGCGCATTCA
GACCCGTATCGACCGTGCGGAAGGTGGAAATTTTGGCGACTGCGAACCTGTTGGCGAAGGCGTGTCAGAAATGCGAATTC
ATTACGGCCCCGGCTATCGAGTGTATTTCGTGCAGCAAGGCATGGAGATTGTGATTTTGCTAGCCGGTGGCGATAAGTCC
ACCCAATCCAAAGATATTAAAGCTGCGCTTGAACTCGCGCGACAGCTATAG

Antitoxin


Download         Length: 100 a.a.        Molecular weight: 10874.80 Da        Isoelectric Point: 10.0948

>AT192208 WP_017145203.1 NZ_CP069943:1079734-1080033 [Klebsiella oxytoca]
MATLKELMAKQSPESQARIAEKVEAMRQVIALSMLREELNLSQAELAKAMGVKQPTIAKMEQADNDPRLSTLKRYVAALG
GELSIDVKLPGGKRIAFHL

Download         Length: 300 bp

>AT192208 NZ_CP092184:c1387140-1386847 [Serratia marcescens]
ATGGGAACTCTAAAACTACGTAAATGGGATAGCGCCGAGCACCTCAACAGTGATGAGGACATCGTTGCCTATCTGGAAGC
CTGCATGGAAGAAGCCGGTGACGATGCAGCTTTCATTGCCAAGGCATTGGGAAACATCGCCCGCGCTCGCGGCATGACTC
AACTCGCCAAGGAAACAGGCGTAGGCCGCGAAAGCCTATACAAAGCGTTGTCAGGAGAGGGTAACCCGAGTTTCGGCACA
ATCCTGAAAGTCATGCATGCTCTCGGGTTACGCCTACACACTACGGCTGCCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References