Detailed information of TA system TA192166

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): hok-sok/-
• Location: 4641178..4641436
• Replicon: chromosome
• Accession: NZ_CP069935
• Organism: Escherichia coli strain FDAARGOS_1302

Toxin (Protein)

• Gene name: hokC
• Uniprot ID: S1NX00
• Locus tag: I6K32_RS22500
• Protein ID: WP_000809168.1
• Coordinates: 4641178..4641330 (-)
• Length: 51 a.a.

Antitoxin (RNA)

Gene name	sokC
Locus tag	-
Coordinates	4641379..4641436 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
I6K32_RS22480	4636423..4637136	-	714	WP_001102393.1	acidic protein MsyB	-
I6K32_RS22485	4637162..4637566	-	405	WP_000843687.1	DUF2541 family protein	-
I6K32_RS22490	4637938..4639854	+	1917	WP_000516135.1	molecular chaperone DnaK	-
I6K32_RS22495	4639943..4641073	+	1131	WP_001118464.1	molecular chaperone DnaJ	-
I6K32_RS22500	4641178..4641330	-	153	WP_000809168.1	type I toxin-antitoxin system toxin MokC	Toxin
-	4641379..4641436	+	58	-	-	Antitoxin
I6K32_RS22505	4641942..4642703	+	762	WP_001274823.1	outer membrane protein OmpK	-
I6K32_RS22510	4642723..4644216	+	1494	WP_001350775.1	sulfatase-like hydrolase/transferase	-
I6K32_RS22515	4644345..4645604	+	1260	WP_000494924.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Hok/gef cell toxic protein (6-47)

Sequences

Toxin

Protein

• Length: 51 a.a.
• Molecular weight: 5501.57 Da
• Isoelectric Point: 7.1312

>T192166 WP_000809168.1 NZ_CP069935:c4641330-4641178 [Escherichia coli]
MKQHKAMIVALIVICITAVVAALVTRKDLCEVHIRTGQTEVAVFTAYESE

Nucleotide

• Length: 153 bp

>T192166 NZ_CP092112:c736053-735712 [Leptospira noguchii]
ATGATTCGTGGTGAGATCTGGTGGGTGGACTTAGGAATTCCATTTGGAAGTGAACCTGGATTTAAGAGACCCGTTTTGAT
TATTCAAGATGACTCTTTTAATCAAAGTAGTATCAGTACTGTAGTATCGATTGCGATTACATCAAATTTAAATTTGTCTG
AAGCTCCTGGCAATGTTCTGATCAGTAAGAAAGAATCCAGCTTATCAAAAGATTCAGTTGTGAATGTCTCTCAAATCGTG
ACTTTAGATAAAGAGAGATTCATTAAACGGGCGGGAAAGCTTAAATCAAGTAAGATCAACGAAGTTGAAACAGGCCTCAA
GTTAGTTACAGGCTTAAATTAA

Antitoxin

Nucleotide

• Length: 58 bp

>AT192166 NZ_CP069935:4641379-4641436 [Escherichia coli]
GTTCTGCATATAGGGGGCCTCGGGTTGATGGTAAAATATCACTCGGGGCTTTTCTCTA

Structures

Toxin

• AlphaFold DB: S1NX00

Antitoxin