Detailed information of TA system TA192162

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): symER/SymE(toxin)
• Location: 4560528..4560940
• Replicon: chromosome
• Accession: NZ_CP069935
• Organism: Escherichia coli strain FDAARGOS_1302

Toxin (Protein)

• Gene name: symE
• Uniprot ID: A0A8E0IWC4
• Locus tag: I6K32_RS22110
• Protein ID: WP_001513534.1
• Coordinates: 4560528..4560869 (-)
• Length: 114 a.a.

Antitoxin (RNA)

Gene name	symR
Locus tag	-
Coordinates	4560864..4560940 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
I6K32_RS22090 (4555597)	4555597..4556877	-	1281	WP_001338077.1	DUF445 domain-containing protein	-
I6K32_RS22095 (4557062)	4557062..4557982	+	921	WP_001513532.1	Rpn family recombination-promoting nuclease/putative transposase	-
I6K32_RS22100 (4558210)	4558210..4558290	+	81	WP_020233658.1	hypothetical protein	-
I6K32_RS25235 (4558388)	4558388..4559264	+	877	Protein_4359	DUF262 domain-containing protein	-
I6K32_RS25240 (4559318)	4559318..4560481	+	1164	WP_224153787.1	DUF1524 domain-containing protein	-
I6K32_RS22110 (4560528)	4560528..4560869	-	342	WP_001513534.1	endoribonuclease SymE	Toxin
- (4560864)	4560864..4560940	+	77	NuclAT_6	-	Antitoxin
- (4560864)	4560864..4560940	+	77	NuclAT_6	-	Antitoxin
- (4560864)	4560864..4560940	+	77	NuclAT_6	-	Antitoxin
- (4560864)	4560864..4560940	+	77	NuclAT_6	-	Antitoxin
- (4560864)	4560864..4560940	+	77	NuclAT_7	-	Antitoxin
- (4560864)	4560864..4560940	+	77	NuclAT_7	-	Antitoxin
- (4560864)	4560864..4560940	+	77	NuclAT_7	-	Antitoxin
- (4560864)	4560864..4560940	+	77	NuclAT_7	-	Antitoxin
I6K32_RS22115 (4561090)	4561090..4562859	-	1770	WP_001513535.1	restriction endonuclease subunit S	-
I6K32_RS22120 (4562859)	4562859..4564328	-	1470	WP_001387312.1	type I restriction-modification system subunit M	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin SymE-like (20-71)

Sequences

Toxin

Protein

• Length: 114 a.a.
• Molecular weight: 12247.03 Da
• Isoelectric Point: 7.8545

>T192162 WP_001513534.1 NZ_CP069935:c4560869-4560528 [Escherichia coli]
MTDTHSIAQPFEAEVSPANNRQLTVSYASHYPDYSRIPAITLKGQWLEAAGFATGTAVDVKVMEGCIVLTAQPPAAAESE
LMQSLRQVCKLSARKQRQVQEFIGVIAGKQKVA

Nucleotide

• Length: 342 bp

>T192162 NZ_CP092107:1705561-1706484 [Vibrio sp. JC009]
ATGAACAAGAACTCCATTTATTATCAGCAGGTAAAGCTTCTTATCAGAATGTTGCCTGTAGTTGCAAAAGAGCAAGTATT
CGCCCTCAAAGGCGGTACTGCAATTAACTTATTTATCCGGGATTTTCCGCGGCTATCGGTAGATATTGACTTGGCATACC
TGCCACTAGAGCCAAGGGAAGAAGCACTTGAAAATGCCAAAGCAGCACTGCAGCGCATTACTGATAACATCAACTCTCAG
CCAGATGTGAAAGCAAAATTTCAGGCTAATAAACCGGATGAGTTGCGAATTGTTGTCTCAAACAGTACCGCAACGGTAAA
AATTGAGGTTTCACCCGTAGCCAGAGGGACGTTACATGAGCCTGAAGTTTTAGAAGTTGCTGAATCAGTAGAAGATGAGT
TTGGGTATGCAGAAATCCCGGTGGTCAGTTTGCCTGATTTGTATGGTGGGAAAATATGTGCAGCGATGGACCGGCAGCAC
CCAAGGGACCTTTTTGATGTAAATATGCTGCTTGAGGCAGAAGGAATTTCAAGGGAAATATTTGTCGGATTTCTAACATA
TGCCCTTGGTCATCCACGACCTATTAACGAAGTGATGGCACCAAACTGGCAACCGCTAGAAACGAAGTTTCATGAAGAGT
TTGAGGGGATGACGTTCAGGACGGTAGAGCTTCAGGATCTGGAAGAAACCCGTAGCGAGATGTTGAATGCCCTTAAAGTT
CAGTTTACAGAAAGAGACCGTGATTTTTTGCTCAGCTTTAAACAAGGTGAGCCTGACTGGTCACTATTTGATGTTCCTTC
GATTGAAGAACTACCTGCCATTCGCTGGAAGTTAATCAATTTAAACAAACTGAAAAGTCAAAACCCAGATAAGCATCAGG
AGCTGTTTTCTAAACTTAATCAAGTTACAGAGGAATGGCTCTAA

Antitoxin

Nucleotide

• Length: 77 bp

>AT192162 NZ_CP069935:4560864-4560940 [Escherichia coli]
AGTCATAACTGCTATTCCCTATAAATAGTGATTGTGATTAGCGGTGCGGGTGTGTTGGCGCACATCCGCACCGCGCT

Structures

Antitoxin