Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | yefM-yoeB (relBE)/YoeB-YefM |
| Location | 1739246..1739748 | Replicon | chromosome |
| Accession | NZ_CP069935 | ||
| Organism | Escherichia coli strain FDAARGOS_1302 | ||
Toxin (Protein)
| Gene name | yoeB | Uniprot ID | U9YDH0 |
| Locus tag | I6K32_RS08670 | Protein ID | WP_000767829.1 |
| Coordinates | 1739246..1739500 (-) | Length | 85 a.a. |
Antitoxin (Protein)
| Gene name | yefM | Uniprot ID | S1Q063 |
| Locus tag | I6K32_RS08675 | Protein ID | WP_001259255.1 |
| Coordinates | 1739497..1739748 (-) | Length | 84 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| I6K32_RS08640 (1734261) | 1734261..1734488 | - | 228 | WP_083574903.1 | thiosulfate utilization sulfurtransferase TsuB/YeeD | - |
| I6K32_RS08645 (1734502) | 1734502..1735560 | - | 1059 | WP_000492340.1 | thiosulfate utilization transporter TsuA/YeeE | - |
| I6K32_RS08650 (1735739) | 1735739..1737097 | - | 1359 | WP_000019197.1 | putrescine/proton symporter PlaP | - |
| I6K32_RS08655 (1737087) | 1737087..1737149 | - | 63 | WP_010723108.1 | membrane protein YoeI | - |
| I6K32_RS08660 (1737364) | 1737364..1738293 | - | 930 | WP_000803351.1 | LysR substrate-binding domain-containing protein | - |
| I6K32_RS08665 (1738339) | 1738339..1739163 | - | 825 | WP_000754737.1 | SDR family oxidoreductase | - |
| I6K32_RS08670 (1739246) | 1739246..1739500 | - | 255 | WP_000767829.1 | type II toxin-antitoxin system mRNA interferase toxin YoeB | Toxin |
| I6K32_RS08675 (1739497) | 1739497..1739748 | - | 252 | WP_001259255.1 | YoeB-YefM toxin-antitoxin system antitoxin YefM | Antitoxin |
| I6K32_RS08680 (1740031) | 1740031..1740081 | + | 51 | WP_071593552.1 | his operon leader peptide | - |
| I6K32_RS08685 (1740227) | 1740227..1741126 | + | 900 | WP_000131789.1 | ATP phosphoribosyltransferase | - |
| I6K32_RS08690 (1741132) | 1741132..1742436 | + | 1305 | WP_001513845.1 | histidinol dehydrogenase | - |
| I6K32_RS08695 (1742433) | 1742433..1743503 | + | 1071 | WP_016239284.1 | histidinol-phosphate transaminase | - |
| I6K32_RS08700 (1743503) | 1743503..1744570 | + | 1068 | WP_001513846.1 | bifunctional histidinol-phosphatase/imidazoleglycerol-phosphate dehydratase HisB | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 85 a.a. Molecular weight: 10183.58 Da Isoelectric Point: 8.0353
>T192148 WP_000767829.1 NZ_CP069935:c1739500-1739246 [Escherichia coli]
VKLIWSEESWDDYLYWQETDKRIVKKINELIKDTRRTPFEGKGKPEPLKHNLSGFWSRRITEEHRLVYAVTDDSLLIAAC
RYHY
VKLIWSEESWDDYLYWQETDKRIVKKINELIKDTRRTPFEGKGKPEPLKHNLSGFWSRRITEEHRLVYAVTDDSLLIAAC
RYHY
Download Length: 255 bp
>T192148 NZ_CP092104:c1444409-1444113 [Flagellatimonas centrodinii]
GTGGAGAAACGGACGCCCCACTGCAAGTTGACGAAAGTCAAAGCCCTCGTGACGGCTGGAAGGGTTCGCACGACGCAATC
GGCCCGGCTGGGGGCGGTCGCACTCGGTCTTGAGTACACGGACATGCTCAATGTGCTGATGTCGCTGACATCCGCAGACT
TCTACAAAAGCATGACCACCCACGGCGACCACCGAGTCTGGCAAGACGTGTATCGGCCGCGCACGAAGGCTGGAAACGTT
TACTTGAAGCTGACGGTCATGGAGGACGTCCTCATCGTGTCGTTCAAGGAGCGTTAA
GTGGAGAAACGGACGCCCCACTGCAAGTTGACGAAAGTCAAAGCCCTCGTGACGGCTGGAAGGGTTCGCACGACGCAATC
GGCCCGGCTGGGGGCGGTCGCACTCGGTCTTGAGTACACGGACATGCTCAATGTGCTGATGTCGCTGACATCCGCAGACT
TCTACAAAAGCATGACCACCCACGGCGACCACCGAGTCTGGCAAGACGTGTATCGGCCGCGCACGAAGGCTGGAAACGTT
TACTTGAAGCTGACGGTCATGGAGGACGTCCTCATCGTGTCGTTCAAGGAGCGTTAA
Antitoxin
Download Length: 84 a.a. Molecular weight: 9307.58 Da Isoelectric Point: 4.7954
>AT192148 WP_001259255.1 NZ_CP069935:c1739748-1739497 [Escherichia coli]
MRTISYSEARQNLSATMMKAVEDHAPILITRQNGEACVLMSLEEYNSLEETAYLLRSPANARRLMDSIDSLKSGKGTEKD
IIE
MRTISYSEARQNLSATMMKAVEDHAPILITRQNGEACVLMSLEEYNSLEETAYLLRSPANARRLMDSIDSLKSGKGTEKD
IIE
Download Length: 252 bp
>AT192148 NZ_CP092104:c1444110-1443709 [Flagellatimonas centrodinii]
ATGAAATGCCCCGCCTGCGGTTTCGCCAAACTGGTCCATGACACGCGCAATCTGCCCTTTACCTACAAGGGGGAGCGCAC
GGTGATCCCGGCGGTCACCGGCGATTTCTGCCCGAACTGTCATGAGTCTGTCCTCGATGCATCCGAATCCGACCGCGTGA
TGGGTGCGATGAAGGCGTTCACGCGGCAGGTCAATGCTGCCGCGGTCGATCCCGGATTCATCGCCGGGGTTCGCAAGAAA
CTGGCGCTGGATCAAAAGACGGCGGCCGAGATCTTCGGCGGTGGTGTCAACGCGTTCTCGCGCTACGAAACGGGGAAGAC
GAAACCCCCGTTAGCCTTGGTGAAGCTTCTGAAGGTGCTGGACCGGCACCCGGAGTTGCTCAACGAAATCCGGGCGGGCT
GA
ATGAAATGCCCCGCCTGCGGTTTCGCCAAACTGGTCCATGACACGCGCAATCTGCCCTTTACCTACAAGGGGGAGCGCAC
GGTGATCCCGGCGGTCACCGGCGATTTCTGCCCGAACTGTCATGAGTCTGTCCTCGATGCATCCGAATCCGACCGCGTGA
TGGGTGCGATGAAGGCGTTCACGCGGCAGGTCAATGCTGCCGCGGTCGATCCCGGATTCATCGCCGGGGTTCGCAAGAAA
CTGGCGCTGGATCAAAAGACGGCGGCCGAGATCTTCGGCGGTGGTGTCAACGCGTTCTCGCGCTACGAAACGGGGAAGAC
GAAACCCCCGTTAGCCTTGGTGAAGCTTCTGAAGGTGCTGGACCGGCACCCGGAGTTGCTCAACGAAATCCGGGCGGGCT
GA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|