Detailed information of TA system TA192093

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): hok-sok/-
• Location: 44397..44666
• Replicon: plasmid unnamed1
• Accession: NZ_CP069894
• Organism: Escherichia coli strain FDAARGOS_1286

Toxin (Protein)

• Gene name: hok
• Uniprot ID: -
• Locus tag: I6K16_RS24425
• Protein ID: WP_001372321.1
• Coordinates: 44541..44666 (+)
• Length: 42 a.a.

Antitoxin (RNA)

Gene name	sok
Locus tag	-
Coordinates	44397..44462 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
I6K16_RS24390	39469..39717	+	249	WP_002433376.1	hypothetical protein	-
I6K16_RS24395	40190..40717	+	528	WP_000290793.1	single-stranded DNA-binding protein	-
I6K16_RS24400	40773..41006	+	234	WP_000006004.1	DUF905 domain-containing protein	-
I6K16_RS24405	41065..43023	+	1959	WP_001145470.1	ParB/RepB/Spo0J family partition protein	-
I6K16_RS24410	43078..43512	+	435	WP_000845949.1	conjugation system SOS inhibitor PsiB	-
I6K16_RS24415	43509..44271	+	763	Protein_46	plasmid SOS inhibition protein A	-
I6K16_RS24420	44240..44428	-	189	WP_001299721.1	hypothetical protein	-
-	44240..44464	+	225	NuclAT_0	-	-
-	44240..44464	+	225	NuclAT_0	-	-
-	44240..44464	+	225	NuclAT_0	-	-
-	44240..44464	+	225	NuclAT_0	-	-
-	44397..44462	-	66	-	-	Antitoxin
I6K16_RS25435	44450..44599	+	150	Protein_48	plasmid maintenance protein Mok	-
I6K16_RS24425	44541..44666	+	126	WP_001372321.1	type I toxin-antitoxin system Hok family toxin	Toxin
I6K16_RS25440	44886..45116	+	231	WP_001426396.1	hypothetical protein	-
I6K16_RS25445	45114..45287	-	174	Protein_51	hypothetical protein	-
I6K16_RS24430	45357..45563	+	207	WP_000547939.1	hypothetical protein	-
I6K16_RS24435	45588..45875	+	288	WP_000107535.1	hypothetical protein	-
I6K16_RS24440	45996..46817	+	822	WP_001234469.1	DUF932 domain-containing protein	-
I6K16_RS24445	47114..47716	-	603	WP_000243709.1	transglycosylase SLT domain-containing protein	-
I6K16_RS24450	48037..48420	+	384	WP_001151524.1	conjugal transfer relaxosome DNA-binding protein TraM	-
I6K16_RS24455	48607..49296	+	690	WP_000283385.1	conjugal transfer transcriptional regulator TraJ	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Conjugative plasmid	sitABCD	iucA / iucB / iucC / iucD / iutA / vat / iroN / iroE / iroD / iroC / iroB	1..153221	153221

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Hok/gef cell toxic protein (2-37)

Sequences

Toxin

Protein

• Length: 42 a.a.
• Molecular weight: 4780.69 Da
• Isoelectric Point: 8.5110

>T192093 WP_001372321.1 NZ_CP069894:44541-44666 [Escherichia coli]
VLIVCLTLLIFTYLTRKSLCEIRYRDGHREVAAFMAYESGK

Nucleotide

• Length: 126 bp

>T192093 NZ_CP092070:217199-217612 [Pectobacterium sp. PL64]
GTGGCCCAGTGGCGATGTGACCTTCGCGTTTCCTGGCGCATGCAACTGCTGTCATTGGTTGTGCATGGCCTATTAGTATT
GCTCATTCTGCTGGCACCGTGGCCGGACGGCTACGCGTGGCTATGGCTATGCCTGGTCACGATGGTGATGTTCGGTTTTA
TCCGTAGCCAACGGAATATTAAATCCCGACAGGGGGAAATCGTTCTGCTCAGCGAAACGACCCTGAACTGGCGGCAGCAG
GAATGGCAGATCGTTAAACGACCGTGGCTGCTGAAGAATGGCGTATTACTGTCATTACAAGCGGTTAACGGTAAAGACAA
GCAACAGCTGTGGCTGGCATCGGACAGCATGGGCGATGACGAATGGCGTCACTTGCGCCAAATTCTTTTGCAGCAGAAAC
ACTGGGCAAGATAG

Antitoxin

Nucleotide

• Length: 66 bp

>AT192093 NZ_CP069894:c44462-44397 [Escherichia coli]
GTGGACTAGACATAGGGATGCCTCGTGGTGGTTAATGAAAATTAACTTACTACGGGGCTATCTTCT

Structures

Antitoxin