Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) ldrD-rdlD/Ldr(toxin)
Location 2202136..2202358 Replicon chromosome
Accession NZ_CP069893
Organism Escherichia coli strain FDAARGOS_1286

Toxin (Protein)


Gene name ldrD Uniprot ID S1NWX0
Locus tag I6K16_RS10635 Protein ID WP_001295224.1
Coordinates 2202136..2202243 (-) Length 36 a.a.

Antitoxin (RNA)


Gene name rdlD
Locus tag -
Coordinates 2202300..2202358 (+)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I6K16_RS10610 2197389..2198141 - 753 Protein_2091 cellulose biosynthesis protein BcsQ -
I6K16_RS10615 2198153..2198341 - 189 WP_001063315.1 cellulose biosynthesis protein BcsR -
I6K16_RS10620 2198614..2200185 + 1572 WP_001204944.1 cellulose biosynthesis c-di-GMP-binding protein BcsE -
I6K16_RS10625 2200182..2200373 + 192 WP_000988308.1 cellulose biosynthesis protein BcsF -
I6K16_RS10630 2200370..2202049 + 1680 WP_001562264.1 cellulose biosynthesis protein BcsG -
I6K16_RS10635 2202136..2202243 - 108 WP_001295224.1 type I toxin-antitoxin system toxin Ldr family protein Toxin
- 2202300..2202358 + 59 - - Antitoxin
I6K16_RS10640 2202619..2202726 - 108 WP_001295224.1 type I toxin-antitoxin system toxin Ldr family protein -
I6K16_RS10645 2203102..2203209 - 108 WP_001295224.1 type I toxin-antitoxin system toxin Ldr family protein -
I6K16_RS10650 2203585..2203692 - 108 WP_000170738.1 type I toxin-antitoxin system toxin Ldr family protein -
I6K16_RS10655 2204168..2205439 + 1272 WP_001318103.1 aromatic amino acid transport family protein -
I6K16_RS10660 2205469..2206473 - 1005 WP_000107036.1 dipeptide ABC transporter ATP-binding subunit DppF -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Type I toxin-antitoxin system, toxin Ldr

(1-35)


Sequences

Toxin        


Download         Length: 36 a.a.        Molecular weight: 3882.70 Da        Isoelectric Point: 9.0157

>T192077 WP_001295224.1 NZ_CP069893:c2202243-2202136 [Escherichia coli]
MTLAELGMAFWHDLAAPVIAGILASMIVNWLNKRK

Download         Length: 108 bp

>T192077 NZ_CP092055:c1936408-1936232 [Staphylococcus aureus]
TTGGATAGATGGTGGCTATCTGAGTATAAGGAGGTGGTGCCTATGGTGGCATTACTGAAATCTTTAGAAAGGAGACGCCT
AATGATTACAATTAGTACCATGTTGCAGTTTGGTTTATTCCTTATTGCATTGATAGGTCTAGTAATCAAGCTTATTGAAT
TAAGCAATAAAAAATAA

Antitoxin


Download         Length: 59 bp

>AT192077 NZ_CP069893:2202300-2202358 [Escherichia coli]
TCAAGAATGGCCCCCGTGGTGTTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTTCTC

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A4P7TSJ7

Antitoxin

Download structure file

References