Detailed information of TA system TA192063

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): yefM-yoeB (relBE)/YoeB-RelB
• Location: 1388953..1389466
• Replicon: chromosome
• Accession: NZ_CP069892
• Organism: Streptococcus anginosus strain FDAARGOS_1357

Toxin (Protein)

• Gene name: yoeB
• Uniprot ID: -
• Locus tag: I6K87_RS06725
• Protein ID: WP_204982495.1
• Coordinates: 1389212..1389466 (+)
• Length: 85 a.a.

Antitoxin (Protein)

• Gene name: yefM
• Uniprot ID: A0A0P0N6Y5
• Locus tag: I6K87_RS06720
• Protein ID: WP_003027139.1
• Coordinates: 1388953..1389219 (+)
• Length: 89 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
I6K87_RS06715	1387041..1388438	-	1398	WP_204982494.1	MucBP domain-containing protein	-
I6K87_RS06720	1388953..1389219	+	267	WP_003027139.1	type II toxin-antitoxin system prevent-host-death family antitoxin	Antitoxin
I6K87_RS06725	1389212..1389466	+	255	WP_204982495.1	Txe/YoeB family addiction module toxin	Toxin
I6K87_RS06730	1389748..1390128	+	381	WP_049517630.1	type II toxin-antitoxin system RelE/ParE family toxin	-
I6K87_RS06735	1390115..1390390	+	276	WP_003024346.1	helix-turn-helix domain-containing protein	-
I6K87_RS06740	1390500..1390857	-	358	Protein_1331	type II toxin-antitoxin system death-on-curing family toxin	-
I6K87_RS06745	1390854..1391111	-	258	WP_003027150.1	type II toxin-antitoxin system Phd/YefM family antitoxin	-
I6K87_RS06750	1391600..1391719	+	120	Protein_1333	site-specific integrase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin YoeB (4-83)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-74)

Sequences

Toxin

Protein

• Length: 85 a.a.
• Molecular weight: 10427.85 Da
• Isoelectric Point: 8.3580

>T192063 WP_204982495.1 NZ_CP069892:1389212-1389466 [Streptococcus anginosus]
MFNFTEQAWKDYVSWQQEDKKILKRINRLIEDIKRNPFEGIGKPEPLKYRYSGAWSRRITDEQQLVYMVEKDEIYFLSFR
DHYT

Nucleotide

• Length: 255 bp

>T192063 NZ_CP092044:5265-5747 [Enterobacter cloacae]
GTGGGACGTATAACCACGCCCGAGCCGTTATCCAGCTCTCATCAGCTGGCTGAGTTCGTCAGTGGAGAGACAGTCCTCGA
TGAATGGCTAAAACAGAGAGGTTTAAAAAATCAAGCTCTTGGCGCTGCCCGAACGTTCGTTGTTTGCAAGACGGGTACGA
AGCAAGTAGCTGGTTTTTACTCTTTGGCCACCGGTAGCGTTAACCATACGGAAGCGACAGGTAGTCTTCGGCGTAACATG
CCAGATCCTATACCGGTGATTATACTCGCTCGCCTGGCGGTAGATGTCTCATTGCACGGAAAAGGGGTTGGCGCCGATTT
ACTCCACGATGCAGTGCTACGGTGTTATCGCGTAGCTGAGAACATTGGGGTTCGTGCGATAATGGTTCATGCGCTTACTG
AAGAAGCCAAAGGTTTCTATGCTCACCATGGATTTAAGGCATCACAAACTCATGAGAGGACTCTGTTTCTAAAGCTTCCA
TGA

Antitoxin

Protein

• Length: 89 a.a.
• Molecular weight: 10475.03 Da
• Isoelectric Point: 5.8648

>AT192063 WP_003027139.1 NZ_CP069892:1388953-1389219 [Streptococcus anginosus]
MEAVVYSNFRNNLKHYMKKVNDEYEPLMVVNKNPDENIVVLSKKNWDSIQETIRLMNNEYLSDKVLSGMEQVKQKKTIQR
QLLEVEDV

Nucleotide

• Length: 267 bp

>AT192063 NZ_CP092044:5011-5277 [Enterobacter cloacae]
ATGAAATCAGATGTTCAACTCAACCTAAGAGCTAAAGAGTCTCAGAGAGCACTCATCGATGCTGCTGCAGAGATCCTTCA
TAAATCGCGAACCGACTTTATCCTGGAGATGGCCTGCAAGGCTGCGGAGAATGTGATCCTTGATCGCCGTGTTTTCAATT
TTAACGACGAACAGTATGCAGAGTTCATCGATATGCTCGATGCACCAGTCGAGGATGAGCCCGCCATTAATAAACTACTG
GCAAGGAAACCTCAGTGGGACGTATAA

Structures

Antitoxin

• AlphaFold DB: A0A0P0N6Y5