Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) ldrD-rdlD/Ldr(toxin)
Location 3989158..3989379 Replicon chromosome
Accession NZ_CP069890
Organism Escherichia coli strain FDAARGOS_1295

Toxin (Protein)


Gene name ldrD Uniprot ID S1PGT3
Locus tag I6K25_RS19195 Protein ID WP_000170954.1
Coordinates 3989158..3989265 (-) Length 36 a.a.

Antitoxin (RNA)


Gene name rdlD
Locus tag -
Coordinates 3989318..3989379 (+)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I6K25_RS19170 (3985003) 3985003..3986085 + 1083 WP_000804726.1 peptide chain release factor 1 -
I6K25_RS19175 (3986085) 3986085..3986918 + 834 WP_000456474.1 peptide chain release factor N(5)-glutamine methyltransferase -
I6K25_RS19180 (3986915) 3986915..3987307 + 393 WP_000200375.1 invasion regulator SirB2 -
I6K25_RS19185 (3987311) 3987311..3988120 + 810 WP_001257054.1 invasion regulator SirB1 -
I6K25_RS19190 (3988156) 3988156..3989010 + 855 WP_000811065.1 3-deoxy-8-phosphooctulonate synthase -
I6K25_RS19195 (3989158) 3989158..3989265 - 108 WP_000170954.1 type I toxin-antitoxin system toxin Ldr family protein Toxin
- (3989318) 3989318..3989379 + 62 NuclAT_12 - Antitoxin
- (3989318) 3989318..3989379 + 62 NuclAT_12 - Antitoxin
- (3989318) 3989318..3989379 + 62 NuclAT_12 - Antitoxin
- (3989318) 3989318..3989379 + 62 NuclAT_12 - Antitoxin
- (3989318) 3989318..3989379 + 62 NuclAT_13 - Antitoxin
- (3989318) 3989318..3989379 + 62 NuclAT_13 - Antitoxin
- (3989318) 3989318..3989379 + 62 NuclAT_13 - Antitoxin
- (3989318) 3989318..3989379 + 62 NuclAT_13 - Antitoxin
- (3989318) 3989318..3989379 + 62 NuclAT_14 - Antitoxin
- (3989318) 3989318..3989379 + 62 NuclAT_14 - Antitoxin
- (3989318) 3989318..3989379 + 62 NuclAT_14 - Antitoxin
- (3989318) 3989318..3989379 + 62 NuclAT_14 - Antitoxin
- (3989318) 3989318..3989379 + 62 NuclAT_15 - Antitoxin
- (3989318) 3989318..3989379 + 62 NuclAT_15 - Antitoxin
- (3989318) 3989318..3989379 + 62 NuclAT_15 - Antitoxin
- (3989318) 3989318..3989379 + 62 NuclAT_15 - Antitoxin
- (3989318) 3989318..3989379 + 62 NuclAT_16 - Antitoxin
- (3989318) 3989318..3989379 + 62 NuclAT_16 - Antitoxin
- (3989318) 3989318..3989379 + 62 NuclAT_16 - Antitoxin
- (3989318) 3989318..3989379 + 62 NuclAT_16 - Antitoxin
- (3989318) 3989318..3989379 + 62 NuclAT_17 - Antitoxin
- (3989318) 3989318..3989379 + 62 NuclAT_17 - Antitoxin
- (3989318) 3989318..3989379 + 62 NuclAT_17 - Antitoxin
- (3989318) 3989318..3989379 + 62 NuclAT_17 - Antitoxin
- (3989318) 3989318..3989380 + 63 NuclAT_10 - -
- (3989318) 3989318..3989380 + 63 NuclAT_10 - -
- (3989318) 3989318..3989380 + 63 NuclAT_10 - -
- (3989318) 3989318..3989380 + 63 NuclAT_10 - -
- (3989318) 3989318..3989380 + 63 NuclAT_11 - -
- (3989318) 3989318..3989380 + 63 NuclAT_11 - -
- (3989318) 3989318..3989380 + 63 NuclAT_11 - -
- (3989318) 3989318..3989380 + 63 NuclAT_11 - -
- (3989318) 3989318..3989380 + 63 NuclAT_6 - -
- (3989318) 3989318..3989380 + 63 NuclAT_6 - -
- (3989318) 3989318..3989380 + 63 NuclAT_6 - -
- (3989318) 3989318..3989380 + 63 NuclAT_6 - -
- (3989318) 3989318..3989380 + 63 NuclAT_7 - -
- (3989318) 3989318..3989380 + 63 NuclAT_7 - -
- (3989318) 3989318..3989380 + 63 NuclAT_7 - -
- (3989318) 3989318..3989380 + 63 NuclAT_7 - -
- (3989318) 3989318..3989380 + 63 NuclAT_8 - -
- (3989318) 3989318..3989380 + 63 NuclAT_8 - -
- (3989318) 3989318..3989380 + 63 NuclAT_8 - -
- (3989318) 3989318..3989380 + 63 NuclAT_8 - -
- (3989318) 3989318..3989380 + 63 NuclAT_9 - -
- (3989318) 3989318..3989380 + 63 NuclAT_9 - -
- (3989318) 3989318..3989380 + 63 NuclAT_9 - -
- (3989318) 3989318..3989380 + 63 NuclAT_9 - -
- (3989318) 3989318..3989381 + 64 NuclAT_18 - -
- (3989318) 3989318..3989381 + 64 NuclAT_18 - -
- (3989318) 3989318..3989381 + 64 NuclAT_18 - -
- (3989318) 3989318..3989381 + 64 NuclAT_18 - -
- (3989318) 3989318..3989381 + 64 NuclAT_19 - -
- (3989318) 3989318..3989381 + 64 NuclAT_19 - -
- (3989318) 3989318..3989381 + 64 NuclAT_19 - -
- (3989318) 3989318..3989381 + 64 NuclAT_19 - -
- (3989318) 3989318..3989381 + 64 NuclAT_20 - -
- (3989318) 3989318..3989381 + 64 NuclAT_20 - -
- (3989318) 3989318..3989381 + 64 NuclAT_20 - -
- (3989318) 3989318..3989381 + 64 NuclAT_20 - -
- (3989318) 3989318..3989381 + 64 NuclAT_21 - -
- (3989318) 3989318..3989381 + 64 NuclAT_21 - -
- (3989318) 3989318..3989381 + 64 NuclAT_21 - -
- (3989318) 3989318..3989381 + 64 NuclAT_21 - -
- (3989318) 3989318..3989381 + 64 NuclAT_22 - -
- (3989318) 3989318..3989381 + 64 NuclAT_22 - -
- (3989318) 3989318..3989381 + 64 NuclAT_22 - -
- (3989318) 3989318..3989381 + 64 NuclAT_22 - -
- (3989318) 3989318..3989381 + 64 NuclAT_23 - -
- (3989318) 3989318..3989381 + 64 NuclAT_23 - -
- (3989318) 3989318..3989381 + 64 NuclAT_23 - -
- (3989318) 3989318..3989381 + 64 NuclAT_23 - -
I6K25_RS19200 (3989671) 3989671..3990771 - 1101 WP_001313768.1 sodium-potassium/proton antiporter ChaA -
I6K25_RS19205 (3991041) 3991041..3991271 + 231 WP_001146444.1 putative cation transport regulator ChaB -
I6K25_RS19210 (3991429) 3991429..3992124 + 696 WP_000632706.1 glutathione-specific gamma-glutamylcyclotransferase -
I6K25_RS19215 (3992168) 3992168..3992521 - 354 WP_001169659.1 DsrE/F sulfur relay family protein YchN -
I6K25_RS19220 (3992706) 3992706..3994100 + 1395 WP_000086194.1 inverse autotransporter invasin YchO -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Type I toxin-antitoxin system, toxin Ldr

(1-35)


Sequences

Toxin        


Download         Length: 36 a.a.        Molecular weight: 3983.80 Da        Isoelectric Point: 11.4779

>T192046 WP_000170954.1 NZ_CP069890:c3989265-3989158 [Escherichia coli]
MTLAQFAMIFWHDLAAPILAGIITAAIVGWWRNRK

Download         Length: 108 bp

>T192046 NZ_CP092040:c4646463-4646152 [Salmonella enterica subsp. enterica serovar Infantis]
GTGCATGTTATCAGCCGAAAACCGTTCAATGAAGCGATGCTCATGTATCCAAACCATGAGCTTGCTCTCACTGAGTTGCT
GAATGTTCTGGAGAAAAAAACATTCACTCAGCCTGAAGAGATGAAGCGGTATATTCCTTCACTGGATAATTTTAAGTACA
GAGATAAATGGTGGGTGATTGATGTTTCTGGTAACAGCCTGAGACTCATTTCCTACATAGATTTCAGGTTACATAAGATA
TTTGTGAAACATATCGTTTCCCATGCCGAATATGACAAACTGACCGCATACTATCGGGGTAATAAAGAATGA

Antitoxin


Download         Length: 62 bp

>AT192046 NZ_CP069890:3989318-3989379 [Escherichia coli]
TGGTTCAAGATTAGCCCCCGTTCTGTTGTCAGGTTTTACCTCTCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U9LPE9

Antitoxin

Download structure file

References