Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | higBA (relBE)/HTH(antitoxin) |
| Location | 2363487..2364089 | Replicon | chromosome |
| Accession | NZ_CP069865 | ||
| Organism | Escherichia coli strain FDAARGOS_1282 | ||
Toxin (Protein)
| Gene name | higB | Uniprot ID | U9XIS6 |
| Locus tag | I6K12_RS11890 | Protein ID | WP_000897305.1 |
| Coordinates | 2363487..2363798 (+) | Length | 104 a.a. |
Antitoxin (Protein)
| Gene name | higA | Uniprot ID | - |
| Locus tag | I6K12_RS11895 | Protein ID | WP_000356395.1 |
| Coordinates | 2363799..2364089 (+) | Length | 97 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| I6K12_RS11870 (2358528) | 2358528..2358965 | + | 438 | WP_000560983.1 | D-aminoacyl-tRNA deacylase | - |
| I6K12_RS11875 (2359010) | 2359010..2359951 | + | 942 | WP_001297068.1 | fatty acid biosynthesis protein FabY | - |
| I6K12_RS25750 (2360367) | 2360367..2361254 | + | 888 | Protein_2195 | hypothetical protein | - |
| I6K12_RS25755 (2361267) | 2361267..2362181 | + | 915 | WP_077634137.1 | transposase | - |
| I6K12_RS11885 (2362350) | 2362350..2363258 | - | 909 | WP_001306651.1 | alpha/beta hydrolase | - |
| I6K12_RS11890 (2363487) | 2363487..2363798 | + | 312 | WP_000897305.1 | hypothetical protein | Toxin |
| I6K12_RS11895 (2363799) | 2363799..2364089 | + | 291 | WP_000356395.1 | NadS family protein | Antitoxin |
| I6K12_RS11900 (2364174) | 2364174..2364386 | + | 213 | WP_000197774.1 | hypothetical protein | - |
| I6K12_RS11905 (2364448) | 2364448..2364726 | + | 279 | WP_001306650.1 | hypothetical protein | - |
| I6K12_RS11910 (2365145) | 2365145..2365363 | + | 219 | WP_001295676.1 | CopG family transcriptional regulator | - |
| I6K12_RS11915 (2365582) | 2365582..2365824 | + | 243 | WP_021523315.1 | hypothetical protein | - |
| I6K12_RS11920 (2366006) | 2366006..2366935 | - | 930 | WP_000027708.1 | formate dehydrogenase accessory protein FdhE | - |
| I6K12_RS11925 (2366932) | 2366932..2367567 | - | 636 | WP_204667245.1 | formate dehydrogenase cytochrome b556 subunit | - |
| I6K12_RS11930 (2367564) | 2367564..2368466 | - | 903 | WP_000331377.1 | formate dehydrogenase O subunit beta | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 104 a.a. Molecular weight: 12190.19 Da Isoelectric Point: 9.7791
>T191960 WP_000897305.1 NZ_CP069865:2363487-2363798 [Escherichia coli]
MLFIETEIFTEDVQKLLTDDEFSRFQFFLALNPDYGEVIPETGGLRKVRWVSGGKGKRAGVRVIYFHQVKHYEIRLLLIY
RKGIKDDLSPQEKAMLRLLNTRW
MLFIETEIFTEDVQKLLTDDEFSRFQFFLALNPDYGEVIPETGGLRKVRWVSGGKGKRAGVRVIYFHQVKHYEIRLLLIY
RKGIKDDLSPQEKAMLRLLNTRW
Download Length: 312 bp
>T191960 NZ_CP092009:c1033360-1032833 [Salmonella enterica subsp. enterica serovar Kentucky]
ATGATGTTTACAGACTGGCATGAGGCCGCGATAGGGAAAACCCACAATCGAATGAATTTTGATTGTGGGGATGCCGATCT
GAACCAATTCCTGCAACGCCATGCACGACAAAATCATGAGAAAGGGACAACGAAAACCTATGTTGCGCTTGATAATTCGG
ATGTTACACGTATCCATGGATTTTACTCAGTCAGTCCTGCATCACTGATATATGCACAGGTTCCCGGCGCAATCAGCAAA
GGATTAGGGAGACACGATGTGCCAGTGTTTCGTCTGGGTCGTTTAGCCGTAGACAAATCTATGCAGGGGCAAGGGCTGGG
AGCACAACTTTTGTTATCTGCCGGAAAGCGTTGCATACAGGCGGCTTTGCAGGTCGGTGGCGTAGCCCTGCTTATTGATG
CCAAAAATAAACAGGTCTGCGACTGGTACAAAGGATTTGGCGCAGTACCATTAAACGATCAACCCCTTTCCTTGTTGCTG
TCGTTTAAAACGCTTTATGCGGCTTTATCTGCATCTGGTAGGTTATGA
ATGATGTTTACAGACTGGCATGAGGCCGCGATAGGGAAAACCCACAATCGAATGAATTTTGATTGTGGGGATGCCGATCT
GAACCAATTCCTGCAACGCCATGCACGACAAAATCATGAGAAAGGGACAACGAAAACCTATGTTGCGCTTGATAATTCGG
ATGTTACACGTATCCATGGATTTTACTCAGTCAGTCCTGCATCACTGATATATGCACAGGTTCCCGGCGCAATCAGCAAA
GGATTAGGGAGACACGATGTGCCAGTGTTTCGTCTGGGTCGTTTAGCCGTAGACAAATCTATGCAGGGGCAAGGGCTGGG
AGCACAACTTTTGTTATCTGCCGGAAAGCGTTGCATACAGGCGGCTTTGCAGGTCGGTGGCGTAGCCCTGCTTATTGATG
CCAAAAATAAACAGGTCTGCGACTGGTACAAAGGATTTGGCGCAGTACCATTAAACGATCAACCCCTTTCCTTGTTGCTG
TCGTTTAAAACGCTTTATGCGGCTTTATCTGCATCTGGTAGGTTATGA
Antitoxin
Download Length: 97 a.a. Molecular weight: 10869.46 Da Isoelectric Point: 10.8907
>AT191960 WP_000356395.1 NZ_CP069865:2363799-2364089 [Escherichia coli]
MDKALFERLTHSMAQMNEIIEGTRHPSRTFEVDAMKIKEIRRASGLSQSKFAELISVSVDTLRNWEQGRRSPTGPAKALL
RAIANDPQHVLQALNR
MDKALFERLTHSMAQMNEIIEGTRHPSRTFEVDAMKIKEIRRASGLSQSKFAELISVSVDTLRNWEQGRRSPTGPAKALL
RAIANDPQHVLQALNR
Download Length: 291 bp
>AT191960 NZ_CP092009:c1033647-1033357 [Salmonella enterica subsp. enterica serovar Kentucky]
ATGAAAACCATGCCTCAGATAGCTATAGAATCTAACGAAAGGCTGTCGTTACGTGTATCGACGGATGCCAAAAAGTTGAT
AGTCCGCGCTGCGGCAATCCAGCAAACCAACCTGACGGATTTTGTGGTCAGTAACGTACTACCTGTCGCACAGAAGATTG
TTGATGCCGCCGAACGGGTATATCTGACGGAGCGTGATACTCAAATGATCATGGAAATTTTAGATAACCCGCCAGCGCCG
AATGAAAAGCTTCTTGCTGCTGCTTTCGCCCTGCCGGACATGAAGAAATGA
ATGAAAACCATGCCTCAGATAGCTATAGAATCTAACGAAAGGCTGTCGTTACGTGTATCGACGGATGCCAAAAAGTTGAT
AGTCCGCGCTGCGGCAATCCAGCAAACCAACCTGACGGATTTTGTGGTCAGTAACGTACTACCTGTCGCACAGAAGATTG
TTGATGCCGCCGAACGGGTATATCTGACGGAGCGTGATACTCAAATGATCATGGAAATTTTAGATAACCCGCCAGCGCCG
AATGAAAAGCTTCTTGCTGCTGCTTTCGCCCTGCCGGACATGAAGAAATGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|