Detailed information of TA system TA191958

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): mqsRA (relBE)/MqsR-MqsA
• Location: 1426549..1427242
• Replicon: chromosome
• Accession: NZ_CP069865
• Organism: Escherichia coli strain FDAARGOS_1282

Toxin (Protein)

• Gene name: mqsR
• Uniprot ID: S1EZG2
• Locus tag: I6K12_RS07475
• Protein ID: WP_000415584.1
• Coordinates: 1426946..1427242 (-)
• Length: 99 a.a.

Antitoxin (Protein)

• Gene name: mqsA
• Uniprot ID: S1EBV2
• Locus tag: I6K12_RS07470
• Protein ID: WP_000650107.1
• Coordinates: 1426549..1426944 (-)
• Length: 132 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
I6K12_RS07460 (1422413)	1422413..1424671	-	2259	WP_204667230.1	DNA topoisomerase IV subunit A	-
I6K12_RS07465 (1424809)	1424809..1426416	-	1608	WP_001295629.1	ABC transporter substrate-binding protein	-
I6K12_RS07470 (1426549)	1426549..1426944	-	396	WP_000650107.1	type II toxin-antitoxin system antitoxin MqsA	Antitoxin
I6K12_RS07475 (1426946)	1426946..1427242	-	297	WP_000415584.1	type II toxin-antitoxin system toxin MqsR	Toxin
I6K12_RS07480 (1427447)	1427447..1427929	-	483	WP_000183505.1	GyrI-like domain-containing protein	-
I6K12_RS07485 (1427982)	1427982..1428374	-	393	WP_000712658.1	OB fold stress tolerance protein YgiW	-
I6K12_RS07490 (1428526)	1428526..1429185	+	660	WP_001221493.1	quorum sensing response regulator transcription factor QseB	-
I6K12_RS07495 (1429182)	1429182..1430531	+	1350	WP_000673402.1	quorum sensing histidine kinase QseC	-
I6K12_RS07500 (1430577)	1430577..1430909	-	333	WP_023149630.1	DUF2645 family protein	-
I6K12_RS07505 (1431228)	1431228..1431809	+	582	WP_000065430.1	NADPH:quinone oxidoreductase MdaB	-
I6K12_RS07510 (1431840)	1431840..1432154	+	315	WP_000958598.1	putative quinol monooxygenase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• mRNA interferase toxin MqsR (5-97)

Antitoxin

• Zinc finger, MqsA-type (3-47)

Sequences

Toxin

Protein

• Length: 99 a.a.
• Molecular weight: 11231.96 Da
• Isoelectric Point: 8.9070

>T191958 WP_000415584.1 NZ_CP069865:c1427242-1426946 [Escherichia coli]
MEKRTPHTRLSQVKKLVNAGQVRTTRSALLNADELGLDFDGMCNVIIGLSESDFYKSMTTYSDHTIWQDVYRPRLVTGQV
YLKITVIHDVLIVSFKEK

Nucleotide

• Length: 297 bp

>T191958 NZ_CP092009:299465-299983 [Salmonella enterica subsp. enterica serovar Kentucky]
GTGGACAACCTGACAATAGAGATTCTGGCTGATAACGCAGAATACAACTGGCGGCAGTTCGACTGCGGTGAGGCATCATT
AAACCTTTTTTTAACGCAGCATCTTCAGCGCCAGCATAACAACAAAATCTTGCGCGGTTATGTACTCAGAACCACTACGC
CAGAACGGCGAGTGTTGGGGTATTACACCCTGTCAGGAAGCTGCTTTGAACGCGCGTCGTTGCCTTCCAGAACCCAGCAA
AAGCGCATCCCTTACCAGAATATCCCCAGCGTTACGCTGGGCCGTTTAGCGGTCGATCTCTCATTACAGGGAAAAGGGTG
GGGAGCTATATTGGTCACGCATGCGATGAAAGTGGTGTGGTCGGCATCACTGGCCGTTGGGATTCATGGCATCTTTGTGG
AAGCGTTAAACGAAAAAGCCCAGGCCTTTTATCAGCGGCTGGGCTTTATTTCTTTATCCGGAGAAAACGAGCACGCGCTG
TTTTACCCGACAAAGTCGATTGAGCAACTTTTTGGCTAG

Antitoxin

Protein

• Length: 132 a.a.
• Molecular weight: 14703.10 Da
• Isoelectric Point: 9.2136

>AT191958 WP_000650107.1 NZ_CP069865:c1426944-1426549 [Escherichia coli]
MKCPVCHQGEMVSGIKDIPYTFRGRKTVLKGIHGLYCVHCEESIMNKEESDAFMAQVKAFRASVNAETVAPEFIVKVRKK
LSLTQKEASEIFGGGVNAFSRYEKGNAQPHPSTIKLLRVLDKHPELLNEIR

Nucleotide

• Length: 396 bp

>AT191958 NZ_CP092009:299192-299461 [Salmonella enterica subsp. enterica serovar Kentucky]
ATGTCAGCCCTAAAAAAACAGCGTATCGATCTGCGGCTCACAGACGGCGATAAAAGCATGATTGAAGAAGCGGCCGCCAT
TACTAATCAATCAATCACGCAATTTATGTTGAATAGCGCAGCGGAGCGAGCCGCAGAAGTGCTTGAACAGCACCGTCGGG
TTATTCTTAATGAAGCATCCTGGGCGCGAGTCATGGATGCGCTTAGTCATCCTCCCACCCCCAATGAGAAATTAAAACGC
GCGGCGCAACGTCTACAAGACATGGAGTGA

Structures

Toxin

• PDB: 3HI2

Antitoxin

• AlphaFold DB: A0A7U9LU65