Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | mqsRA (relBE)/MqsR-MqsA |
| Location | 1426549..1427242 | Replicon | chromosome |
| Accession | NZ_CP069865 | ||
| Organism | Escherichia coli strain FDAARGOS_1282 | ||
Toxin (Protein)
| Gene name | mqsR | Uniprot ID | S1EZG2 |
| Locus tag | I6K12_RS07475 | Protein ID | WP_000415584.1 |
| Coordinates | 1426946..1427242 (-) | Length | 99 a.a. |
Antitoxin (Protein)
| Gene name | mqsA | Uniprot ID | S1EBV2 |
| Locus tag | I6K12_RS07470 | Protein ID | WP_000650107.1 |
| Coordinates | 1426549..1426944 (-) | Length | 132 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| I6K12_RS07460 (1422413) | 1422413..1424671 | - | 2259 | WP_204667230.1 | DNA topoisomerase IV subunit A | - |
| I6K12_RS07465 (1424809) | 1424809..1426416 | - | 1608 | WP_001295629.1 | ABC transporter substrate-binding protein | - |
| I6K12_RS07470 (1426549) | 1426549..1426944 | - | 396 | WP_000650107.1 | type II toxin-antitoxin system antitoxin MqsA | Antitoxin |
| I6K12_RS07475 (1426946) | 1426946..1427242 | - | 297 | WP_000415584.1 | type II toxin-antitoxin system toxin MqsR | Toxin |
| I6K12_RS07480 (1427447) | 1427447..1427929 | - | 483 | WP_000183505.1 | GyrI-like domain-containing protein | - |
| I6K12_RS07485 (1427982) | 1427982..1428374 | - | 393 | WP_000712658.1 | OB fold stress tolerance protein YgiW | - |
| I6K12_RS07490 (1428526) | 1428526..1429185 | + | 660 | WP_001221493.1 | quorum sensing response regulator transcription factor QseB | - |
| I6K12_RS07495 (1429182) | 1429182..1430531 | + | 1350 | WP_000673402.1 | quorum sensing histidine kinase QseC | - |
| I6K12_RS07500 (1430577) | 1430577..1430909 | - | 333 | WP_023149630.1 | DUF2645 family protein | - |
| I6K12_RS07505 (1431228) | 1431228..1431809 | + | 582 | WP_000065430.1 | NADPH:quinone oxidoreductase MdaB | - |
| I6K12_RS07510 (1431840) | 1431840..1432154 | + | 315 | WP_000958598.1 | putative quinol monooxygenase | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 99 a.a. Molecular weight: 11231.96 Da Isoelectric Point: 8.9070
>T191958 WP_000415584.1 NZ_CP069865:c1427242-1426946 [Escherichia coli]
MEKRTPHTRLSQVKKLVNAGQVRTTRSALLNADELGLDFDGMCNVIIGLSESDFYKSMTTYSDHTIWQDVYRPRLVTGQV
YLKITVIHDVLIVSFKEK
MEKRTPHTRLSQVKKLVNAGQVRTTRSALLNADELGLDFDGMCNVIIGLSESDFYKSMTTYSDHTIWQDVYRPRLVTGQV
YLKITVIHDVLIVSFKEK
Download Length: 297 bp
>T191958 NZ_CP092009:299465-299983 [Salmonella enterica subsp. enterica serovar Kentucky]
GTGGACAACCTGACAATAGAGATTCTGGCTGATAACGCAGAATACAACTGGCGGCAGTTCGACTGCGGTGAGGCATCATT
AAACCTTTTTTTAACGCAGCATCTTCAGCGCCAGCATAACAACAAAATCTTGCGCGGTTATGTACTCAGAACCACTACGC
CAGAACGGCGAGTGTTGGGGTATTACACCCTGTCAGGAAGCTGCTTTGAACGCGCGTCGTTGCCTTCCAGAACCCAGCAA
AAGCGCATCCCTTACCAGAATATCCCCAGCGTTACGCTGGGCCGTTTAGCGGTCGATCTCTCATTACAGGGAAAAGGGTG
GGGAGCTATATTGGTCACGCATGCGATGAAAGTGGTGTGGTCGGCATCACTGGCCGTTGGGATTCATGGCATCTTTGTGG
AAGCGTTAAACGAAAAAGCCCAGGCCTTTTATCAGCGGCTGGGCTTTATTTCTTTATCCGGAGAAAACGAGCACGCGCTG
TTTTACCCGACAAAGTCGATTGAGCAACTTTTTGGCTAG
GTGGACAACCTGACAATAGAGATTCTGGCTGATAACGCAGAATACAACTGGCGGCAGTTCGACTGCGGTGAGGCATCATT
AAACCTTTTTTTAACGCAGCATCTTCAGCGCCAGCATAACAACAAAATCTTGCGCGGTTATGTACTCAGAACCACTACGC
CAGAACGGCGAGTGTTGGGGTATTACACCCTGTCAGGAAGCTGCTTTGAACGCGCGTCGTTGCCTTCCAGAACCCAGCAA
AAGCGCATCCCTTACCAGAATATCCCCAGCGTTACGCTGGGCCGTTTAGCGGTCGATCTCTCATTACAGGGAAAAGGGTG
GGGAGCTATATTGGTCACGCATGCGATGAAAGTGGTGTGGTCGGCATCACTGGCCGTTGGGATTCATGGCATCTTTGTGG
AAGCGTTAAACGAAAAAGCCCAGGCCTTTTATCAGCGGCTGGGCTTTATTTCTTTATCCGGAGAAAACGAGCACGCGCTG
TTTTACCCGACAAAGTCGATTGAGCAACTTTTTGGCTAG
Antitoxin
Download Length: 132 a.a. Molecular weight: 14703.10 Da Isoelectric Point: 9.2136
>AT191958 WP_000650107.1 NZ_CP069865:c1426944-1426549 [Escherichia coli]
MKCPVCHQGEMVSGIKDIPYTFRGRKTVLKGIHGLYCVHCEESIMNKEESDAFMAQVKAFRASVNAETVAPEFIVKVRKK
LSLTQKEASEIFGGGVNAFSRYEKGNAQPHPSTIKLLRVLDKHPELLNEIR
MKCPVCHQGEMVSGIKDIPYTFRGRKTVLKGIHGLYCVHCEESIMNKEESDAFMAQVKAFRASVNAETVAPEFIVKVRKK
LSLTQKEASEIFGGGVNAFSRYEKGNAQPHPSTIKLLRVLDKHPELLNEIR
Download Length: 396 bp
>AT191958 NZ_CP092009:299192-299461 [Salmonella enterica subsp. enterica serovar Kentucky]
ATGTCAGCCCTAAAAAAACAGCGTATCGATCTGCGGCTCACAGACGGCGATAAAAGCATGATTGAAGAAGCGGCCGCCAT
TACTAATCAATCAATCACGCAATTTATGTTGAATAGCGCAGCGGAGCGAGCCGCAGAAGTGCTTGAACAGCACCGTCGGG
TTATTCTTAATGAAGCATCCTGGGCGCGAGTCATGGATGCGCTTAGTCATCCTCCCACCCCCAATGAGAAATTAAAACGC
GCGGCGCAACGTCTACAAGACATGGAGTGA
ATGTCAGCCCTAAAAAAACAGCGTATCGATCTGCGGCTCACAGACGGCGATAAAAGCATGATTGAAGAAGCGGCCGCCAT
TACTAATCAATCAATCACGCAATTTATGTTGAATAGCGCAGCGGAGCGAGCCGCAGAAGTGCTTGAACAGCACCGTCGGG
TTATTCTTAATGAAGCATCCTGGGCGCGAGTCATGGATGCGCTTAGTCATCCTCCCACCCCCAATGAGAAATTAAAACGC
GCGGCGCAACGTCTACAAGACATGGAGTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|