191926

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 796114..796760 Replicon chromosome
Accession NZ_CP069861
Organism Klebsiella pneumoniae strain FDAARGOS_1311

Toxin (Protein)


Gene name higB Uniprot ID W9BBY1
Locus tag I6K41_RS04090 Protein ID WP_016529833.1
Coordinates 796413..796760 (-) Length 116 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID W8UB68
Locus tag I6K41_RS04085 Protein ID WP_002920557.1
Coordinates 796114..796413 (-) Length 100 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I6K41_RS04065 792320..793078 - 759 WP_002920548.1 DeoR/GlpR family transcriptional regulator -
I6K41_RS04070 793128..793958 - 831 WP_024622927.1 rhomboid family intramembrane serine protease GlpG -
I6K41_RS04075 794009..794338 - 330 WP_002920552.1 thiosulfate sulfurtransferase GlpE -
I6K41_RS04080 794543..796051 + 1509 WP_023301456.1 glycerol-3-phosphate dehydrogenase -
I6K41_RS04085 796114..796413 - 300 WP_002920557.1 helix-turn-helix transcriptional regulator Antitoxin
I6K41_RS04090 796413..796760 - 348 WP_016529833.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
I6K41_RS04095 796936..799383 - 2448 WP_002920561.1 glycogen phosphorylase -
I6K41_RS04100 799401..800834 - 1434 WP_002920564.1 glycogen synthase GlgA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(13-107)

Antitoxin

HigA2-like, helix-turn-helix domain

(9-87)


Sequences

Toxin        


Download         Length: 116 a.a.        Molecular weight: 13549.56 Da        Isoelectric Point: 5.6749

>T191926 WP_016529833.1 NZ_CP069861:c796760-796413 [Klebsiella pneumoniae]
MWDVETTDTFDTWFELQSRALKEDMLATMLILSEFAPQLGRPYVDTVKDSTFQNMKELRVQHHGLPIRAFFAFDPLRKAI
VLCAGDKDGMNEKRFYKEMITLADREFSQHLTKER

Download         Length: 348 bp

>T191926 NZ_CP091998:2100856-2100959 [Salmonella enterica subsp. enterica serovar Kentucky]
GGCAAGGCGATTTAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATAC
AGGAATCGTATTCGGTCTCTTTTT

Antitoxin


Download         Length: 100 a.a.        Molecular weight: 10800.58 Da        Isoelectric Point: 10.1464

>AT191926 WP_002920557.1 NZ_CP069861:c796413-796114 [Klebsiella pneumoniae]
MATLKELMAKQSPDSQQRIAAKAAEIRQSVALNLLREELQMSQTEMAAAMGVKQPTIAKMEQADNDPRLSTLKRYIAALG
GELSINVTLPTGKKVSFNL

Download         Length: 300 bp

>AT191926 NZ_CP091998:c2100961-2100818 [Salmonella enterica subsp. enterica serovar Kentucky]
ATAAAAAGAGACCGAATACGATTCCTGTATTCGGTCCAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGTTGGC
ATTAATGCAGGCTAAATCGCCTTGCCCTTTAAGAATAGATGACGACGCCAGGTTTTCCAGTTTG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB W9BBY1

Antitoxin

Source ID Structure
AlphaFold DB A0A0E1CBF8

References