Detailed information of TA system TA191876

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): mqsRA (relBE)/MqsR-MqsA
• Location: 707250..707905
• Replicon: chromosome
• Accession: NZ_CP069843
• Organism: Bordetella pertussis strain FDAARGOS_1369

Toxin (Protein)

• Gene name: mqsR
• Uniprot ID: -
• Locus tag: I6K99_RS03345
• Protein ID: WP_047122780.1
• Coordinates: 707250..707501 (+)
• Length: 84 a.a.

Antitoxin (Protein)

• Gene name: mqsA
• Uniprot ID: Q7VY40
• Locus tag: I6K99_RS03350
• Protein ID: WP_003809516.1
• Coordinates: 707504..707905 (+)
• Length: 134 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
I6K99_RS03320	702411..703541	-	1131	WP_010930401.1	helix-turn-helix transcriptional regulator	-
I6K99_RS03325	703776..704357	+	582	WP_019247931.1	molybdenum cofactor biosysynthesis protein	-
I6K99_RS03330	704494..705558	+	1065	WP_003809510.1	fructose-bisphosphate aldolase class II	-
I6K99_RS03335	705643..706089	-	447	WP_003819827.1	GFA family protein	-
I6K99_RS03340	706314..707195	+	882	WP_003809513.1	phosphoribosylaminoimidazolesuccinocarboxamide synthase	-
I6K99_RS03345	707250..707501	+	252	WP_047122780.1	type II toxin-antitoxin system MqsR family toxin	Toxin
I6K99_RS03350	707504..707905	+	402	WP_003809516.1	type II toxin-antitoxin system MqsA family antitoxin	Antitoxin
I6K99_RS03355	707925..708161	+	237	WP_010930404.1	membrane protein	-
I6K99_RS03360	708169..708648	+	480	WP_010930405.1	disulfide bond formation protein B	-
I6K99_RS03365	708798..709313	+	516	WP_019247930.1	5-(carboxyamino)imidazole ribonucleotide mutase	-
I6K99_RS03370	709316..710506	+	1191	WP_010930406.1	5-(carboxyamino)imidazole ribonucleotide synthase	-
I6K99_RS03375	710526..711563	+	1038	WP_023853543.1	threonylcarbamoyl-AMP synthase	-
I6K99_RS03380	711700..712722	+	1023	WP_003809532.1	amino acid ABC transporter substrate-binding protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• mRNA interferase toxin MqsR (10-82)

Antitoxin

• Antitoxin MqsA/HigA-2 (1-131)

Sequences

Toxin

Protein

• Length: 84 a.a.
• Molecular weight: 8952.52 Da
• Isoelectric Point: 9.7242

>T191876 WP_047122780.1 NZ_CP069843:707250-707501 [Bordetella pertussis]
IGGAATKKPGQKRRAGAAALGLDFSAMVEIVLALTPRDFHKSMTTHADHRIWQDVYCPVTAMGAVYLKLTVLDGVPIVSF
KEL

Nucleotide

• Length: 252 bp

>T191876 NZ_CP091977:3195355-3195786 [Aromatoleum aromaticum]
ATGCTCGATACCAACATCTGCATCTACCTCATCAATCATCGCCCAGCCCACGTGCGCGCCCACTTCGATGGGCACCCGAT
CGGCGACATCGGCGTATCGGTCATCACCGCGGCGGAACTCGCGTATGGCGTAACGAAAAGCGCTTCACCCCGCAACCGTG
CAGCGCTGGAAACCTTTCTGCTGCCGCTGGAGGTGGCCCCTTTTGACGACAGGGCGATCTGGCGCTATGCCGAACTGCGT
ACGCAACTGATGCGACGCGGCACGCCGATCGGCGCGCTCGACACCCAGATTGCGGCGCATGCGCTTGCGCTCGACTGCAC
GCTGGTCACCAACAACACACGCGAATTCGAACGGGTGGACGGCCTGCGCCTGGAAAACTGGGTCGACCAGCGCCTGATGG
AATCCCCTGCCGCTTACTTCACCGCTCCATGA

Antitoxin

Protein

• Length: 134 a.a.
• Molecular weight: 14528.70 Da
• Isoelectric Point: 8.5005

>AT191876 WP_003809516.1 NZ_CP069843:707504-707905 [Bordetella pertussis]
MKCPVCGAAALARDTRDVPYSYKGETITIAAVTGDWCPACGENVLDGAESARVSEAMLAFNRLVNARRVDPGFIVRVRRK
LGLDQREAAALFGGGTNAFSRYENGKTRPPLALVKLLRLLDRHPELLEEVRAD

Nucleotide

• Length: 402 bp

>AT191876 NZ_CP091977:3195119-3195349 [Aromatoleum aromaticum]
ATGGATACCGCCAAACTTTTCACGAACGGCCGCAGCCAGGCGGTACGCCTGCCCAAGGAGTTCCGCTTCGAGGGCGACGA
AGTGTTCATCAAGCGCGTCGGCGACGCCGTCGTGCTGCTGCCGCGCCACGGCTGGGGTACGCTGTTCGGGGCGCTGGAGG
CCTTCGAGCCGGGATTCACGATCGAGCGCGGCGCGCCGGAACAAGCGGAACGCGAGGCGCTGTTGCCGTGA

Structures

Antitoxin

• AlphaFold DB: A0A0H3LKS6