Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mqsRA (relBE)/MqsR-MqsA
Location 166445..167169 Replicon chromosome
Accession NZ_CP069812
Organism Cupriavidus oxalaticus strain Ox1

Toxin (Protein)


Gene name mqsR Uniprot ID A0A375FZR8
Locus tag JTE92_RS13120 Protein ID WP_063241136.1
Coordinates 166445..166741 (+) Length 99 a.a.

Antitoxin (Protein)


Gene name mqsA Uniprot ID A0A375FUY7
Locus tag JTE92_RS13125 Protein ID WP_063241137.1
Coordinates 166768..167169 (+) Length 134 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JTE92_RS13105 162112..163077 + 966 WP_063241133.1 M48 family metallopeptidase -
JTE92_RS13110 163163..165244 + 2082 WP_063241134.1 S8 family peptidase -
JTE92_RS13115 165317..166264 - 948 WP_063241135.1 N-acetyl-gamma-glutamyl-phosphate reductase -
JTE92_RS13120 166445..166741 + 297 WP_063241136.1 type II toxin-antitoxin system MqsR family toxin Toxin
JTE92_RS13125 166768..167169 + 402 WP_063241137.1 type II toxin-antitoxin system MqsA family antitoxin Antitoxin
JTE92_RS13130 167179..167955 - 777 WP_063241138.1 exodeoxyribonuclease III -
JTE92_RS13135 167983..168681 + 699 WP_116386741.1 orotate phosphoribosyltransferase -
JTE92_RS13140 168770..170107 + 1338 WP_063241139.1 patatin-like phospholipase family protein -
JTE92_RS13145 170144..170953 - 810 WP_063241140.1 polyphosphate kinase 2 family protein -
JTE92_RS13150 171052..171918 - 867 WP_063241141.1 diaminopimelate epimerase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase toxin MqsR

(2-96)

Antitoxin

Antitoxin MqsA

(3-131)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 11027.72 Da        Isoelectric Point: 9.3198

>T191833 WP_063241136.1 NZ_CP069812:166445-166741 [Cupriavidus oxalaticus]
MEKGTAHYPLWRVRELIAGGLVNLTTSAFEGARNMSLTRADVLDVVAGLQPADFYKSMTTYTDHTVWQDVYRPSTPYGSI
YLKLTVVEKVLIVSFKAR

Download         Length: 297 bp

>T191833 NZ_CP091931:40490-40831 [Leptospira noguchii]
TTGGTAAAGAATAGAAACTATACTCCTGAAAAAGGAGATATTGTGTGGCTGAACTTTACTCCTCAAGCAGGTCATGAACA
GAAAGGTCGTAGACCTGCACTTGTTTTATCGCCTAAGGAATATAATTCAAAAACAGGGTTAGCAATATTTTGTCCAATTA
CCAGTAAAATTAAAGGTTATCCATTCGAAGTGTTGATTAAATCAAAAAAAATCGATGGTGTAATTCTTTCTGATCAAGTA
AAAAACTTAGATTGGACTATCCGTGAAGCAGAATTTATTGAATCAATAAATAAAGTTTCTTTAAAAGAAGTTTTAGATAA
TATTAAACTATTAATATTCTAA

Antitoxin


Download         Length: 134 a.a.        Molecular weight: 14822.13 Da        Isoelectric Point: 7.6324

>AT191833 WP_063241137.1 NZ_CP069812:166768-167169 [Cupriavidus oxalaticus]
MQCPVCGGAKLERRRKDFVYTYRGESTVFEAVLADWCPKCGEGVLDAEEEERIGPLALAFNKQVNASLIDPAYITGVRKK
LRLDQREAAEIFGGGVNAFSRYETGKTKPPLALVKLLKLLDRHPELLEEVRAA

Download         Length: 402 bp

>AT191833 NZ_CP091931:40260-40496 [Leptospira noguchii]
ATGGAATCAATTATTCAAAAATGGGGTAATAGCTTAGGAATTAGAATTCCAAAAGCAATGGCAACGGAATTAGAGTTAAA
TGATGGAAGCCATGTTGAATTACAATATGAAGGAGATAAGATTGTAATATATCCAATGAAAAAAGCTTCATTGGAAGATA
AACTTTCTAAAATTACGAAACAAAATCTTCACTCTGAAATATCTACTGGTAATTCTATAGGCAATGAAGCTTGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A375FZR8

Antitoxin

Source ID Structure
AlphaFold DB A0A375FUY7

References