Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mqsRA (relBE)/MqsR-MqsA
Location 3622729..3623453 Replicon chromosome
Accession NZ_CP069810
Organism Cupriavidus oxalaticus strain Ox1_mCherry

Toxin (Protein)


Gene name mqsR Uniprot ID A0A375FZR8
Locus tag JTE91_RS29170 Protein ID WP_063241136.1
Coordinates 3623157..3623453 (-) Length 99 a.a.

Antitoxin (Protein)


Gene name mqsA Uniprot ID A0A375FUY7
Locus tag JTE91_RS29165 Protein ID WP_063241137.1
Coordinates 3622729..3623130 (-) Length 134 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JTE91_RS29140 3617980..3618846 + 867 WP_063241141.1 diaminopimelate epimerase -
JTE91_RS29145 3618945..3619754 + 810 WP_063241140.1 polyphosphate kinase 2 family protein -
JTE91_RS29150 3619791..3621128 - 1338 WP_063241139.1 patatin-like phospholipase family protein -
JTE91_RS29155 3621217..3621915 - 699 WP_116386741.1 orotate phosphoribosyltransferase -
JTE91_RS29160 3621943..3622719 + 777 WP_063241138.1 exodeoxyribonuclease III -
JTE91_RS29165 3622729..3623130 - 402 WP_063241137.1 type II toxin-antitoxin system MqsA family antitoxin Antitoxin
JTE91_RS29170 3623157..3623453 - 297 WP_063241136.1 type II toxin-antitoxin system MqsR family toxin Toxin
JTE91_RS29175 3623634..3624581 + 948 WP_063241135.1 N-acetyl-gamma-glutamyl-phosphate reductase -
JTE91_RS29180 3624654..3626735 - 2082 WP_063241134.1 S8 family peptidase -
JTE91_RS29185 3626821..3627786 - 966 WP_063241133.1 M48 family metallopeptidase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase toxin MqsR

(2-96)

Antitoxin

Antitoxin MqsA

(3-131)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 11027.72 Da        Isoelectric Point: 9.3198

>T191830 WP_063241136.1 NZ_CP069810:c3623453-3623157 [Cupriavidus oxalaticus]
MEKGTAHYPLWRVRELIAGGLVNLTTSAFEGARNMSLTRADVLDVVAGLQPADFYKSMTTYTDHTVWQDVYRPSTPYGSI
YLKLTVVEKVLIVSFKAR

Download         Length: 297 bp

>T191830 NZ_CP091927:36210-36590 [Escherichia coli]
ATGAGGCATATATCACCGGAAGAACTGATAGCGCTTCATGATGCGAATATAAGCCGCTACGGCGGCCTGCCGGGAATGTC
AGATCCGGGTAGGGCAGAGGCCATTATCGGGAGAGTTCAGGCCAGAGTTGCCTACGAAGAGATCACCGACCTTTTCGAAG
TCTCCGCCACCTACCTGGTGGCTACAGCGAGAGGGCATATATTCAATGATGCCAATAAGCGTACCGCGCTAAACAGTGCG
CTGTTATTTCTACGCCGTAACGGGGTGCAGGTATTTGATTCACCTGAACTGGCAGACCTTACCGTAGGGGCTGCGACCGG
AGAGATATCTGTATCTTCTGTCGCCGACACGTTACGTAGATTGTATGGTTCCGCGGAGTAG

Antitoxin


Download         Length: 134 a.a.        Molecular weight: 14822.13 Da        Isoelectric Point: 7.6324

>AT191830 WP_063241137.1 NZ_CP069810:c3623130-3622729 [Cupriavidus oxalaticus]
MQCPVCGGAKLERRRKDFVYTYRGESTVFEAVLADWCPKCGEGVLDAEEEERIGPLALAFNKQVNASLIDPAYITGVRKK
LRLDQREAAEIFGGGVNAFSRYETGKTKPPLALVKLLKLLDRHPELLEEVRAA

Download         Length: 402 bp

>AT191830 NZ_CP091927:35989-36210 [Escherichia coli]
ATGCAATCCATTAACTTCCGTACCGCGCGCGGCAACCTTTCTGAAGTGCTCAACAATGTTGAAGCCGGGGAAGAGGTTGA
AATCACCCGCAGAGGCCGTGAGCCAGCAGTAATTGTCAGCAAGGCTACTTTCGAAGCCTACAAAAAAGCGGCGCTGGATG
CTGAATTTGCATCCCTGTTTGACACCCTGGACTCCACCAACAAGGAACTGGTTAACCGATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A375FZR8

Antitoxin

Source ID Structure
AlphaFold DB A0A375FUY7

References