191826

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 1029244..1029862 Replicon chromosome
Accession NZ_CP069809
Organism Cupriavidus oxalaticus strain Ox1_mCherry

Toxin (Protein)


Gene name graT Uniprot ID A0A375GMD0
Locus tag JTE91_RS04535 Protein ID WP_063240603.1
Coordinates 1029584..1029862 (-) Length 93 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID A0A375GIG3
Locus tag JTE91_RS04530 Protein ID WP_063240604.1
Coordinates 1029244..1029573 (-) Length 110 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JTE91_RS04510 1026465..1027382 + 918 WP_063240608.1 LysR family transcriptional regulator -
JTE91_RS04515 1027392..1027754 - 363 WP_063240607.1 hypothetical protein -
JTE91_RS04520 1027907..1028377 + 471 WP_063240606.1 Lrp/AsnC family transcriptional regulator -
JTE91_RS04525 1028558..1029154 + 597 WP_063240605.1 GTP cyclohydrolase II -
JTE91_RS04530 1029244..1029573 - 330 WP_063240604.1 HigA family addiction module antidote protein Antitoxin
JTE91_RS04535 1029584..1029862 - 279 WP_063240603.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(28-92)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(6-94)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10566.15 Da        Isoelectric Point: 8.5135

>T191826 WP_063240603.1 NZ_CP069809:c1029862-1029584 [Cupriavidus oxalaticus]
MIQSFRCFDTAALFDGRYVARFASIEFIAQRKLEMLDDAATLGALRFPPGNRLEKLGGDRKGRYSIRINGQWRICFIWTH
DGPAAVEIIDYH

Download         Length: 279 bp

>T191826 NZ_CP091925:3803526-3803804 [Escherichia coli]
ATGATTCAAAGGGATATTGAATACTCGGGACAATATTCAAAGGATGTAAAACTTGCACAAAAGCGTCATAAGGATATGAA
TAAATTGAAATATCTTATGACGCTTCTTATCAATAATACTTTACCGCTTCCAGCTGTTTATAAAGACCACCCGCTGCAAG
GTTCATGGAAAGGTTATCGCGATGCTCATGTCGAACCGGACTGGATCCTGATTTACAAACTTACCGATAAACTTTTACGA
TTTGAGAGAACTGGAACTCACGCGGCGCTCTTTGGGTAA

Antitoxin


Download         Length: 110 a.a.        Molecular weight: 12292.12 Da        Isoelectric Point: 5.8834

>AT191826 WP_063240604.1 NZ_CP069809:c1029573-1029244 [Cupriavidus oxalaticus]
MARFENGMRPIHPGEILREEYLVPLNMSANALALALRVTPARISEIVREQRGITPDTALRLTRYFGGDARSWMNMQVTYD
LKVAQRDLGERIAAEVVPRAGIDQEIPES

Download         Length: 330 bp

>AT191826 NZ_CP091925:3803263-3803523 [Escherichia coli]
ATGGCTGCTAACGCGTTTGTTCGCGCCCGAATCGATGAAGATCTGAAGAATCAGGCAGCGGACGTACTGGCCGGGATGGG
GCTGACCATCTCTGACCTGGTTCGCATAACCCTCACAAAGGTCGCGCGTGAAAAGGCATTGCCGTTTGATTTACGCGAGC
CTAATCAATTAACCATTCAATCAATCAAAAACAGCGAAGCTGGCATTGATGTTCATAAGGCCAAAGACGCCGATGATTTA
TTTGATAAATTAGGAATTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A375GMD0

Antitoxin

Source ID Structure
AlphaFold DB A0A375GIG3

References