Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-RelB
Location 2536018..2536541 Replicon chromosome
Accession NZ_CP069799
Organism Staphylococcus aureus strain 014S_SA

Toxin (Protein)


Gene name yoeB Uniprot ID A0A0E1VXK4
Locus tag JS513_RS12725 Protein ID WP_000074045.1
Coordinates 2536018..2536284 (-) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID A0A0E1VMY7
Locus tag JS513_RS12730 Protein ID WP_000587619.1
Coordinates 2536284..2536541 (-) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JS513_RS12705 2531324..2532511 - 1188 WP_000026189.1 MFS transporter -
JS513_RS12710 2532907..2533683 - 777 WP_000072147.1 iron export ABC transporter permease subunit FetB -
JS513_RS12715 2533676..2534338 - 663 WP_000923526.1 ATP-binding cassette domain-containing protein -
JS513_RS12720 2534586..2535662 - 1077 WP_001076673.1 M42 family metallopeptidase -
JS513_RS12725 2536018..2536284 - 267 WP_000074045.1 Txe/YoeB family addiction module toxin Toxin
JS513_RS12730 2536284..2536541 - 258 WP_000587619.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
JS513_RS12735 2536901..2537356 + 456 WP_000732082.1 DUF1307 domain-containing protein -
JS513_RS12740 2537524..2539101 - 1578 WP_000143502.1 FMN-binding glutamate synthase family protein -
JS513_RS12745 2539296..2540045 + 750 WP_000072440.1 hypothetical protein -
JS513_RS12750 2540290..2541483 - 1194 WP_000675402.1 MFS transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(9-87)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-68)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10632.36 Da        Isoelectric Point: 10.2519

>T191824 WP_000074045.1 NZ_CP069799:c2536284-2536018 [Staphylococcus aureus]
MSNYTVKIKNSAKSDLKKIKHPYLKKTFIEIVETLKNDPYKITQSFEKLEPKYLERYSRRINLQHRVVYTIDDRNKVVLI
LSAWSHYD

Download         Length: 267 bp

>T191824 NZ_CP091925:c3675348-3674971 [Escherichia coli]
CTGAAAACATTACCTGACACACACGTACGGGAGGCATCGTGCTGCCCGTCTCCCGTCACCATCTGGCAGACACTGCTCAC
CCGACTGCTGGACCAGCATTACGGCCTCACACTGAATGACACACCGTTCGCTGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGGATTTCACTGTGTGATGCGGTGAACTTTCTCGTTGAAAAATACGCGCTGGTGCGCACCGACCAGCCGGGATTC
AGCGCCTGTACCCACTCTCAGTTAATCAACAGTATCGATATCCTCCGGGCCCGCCGGGCGACAGGCCTGATGACCCGCGA
CAATTACAGAACGGTAAATAACATTACCCGGGGTAAACATCCGGGGGCGAAACAATGA

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9735.76 Da        Isoelectric Point: 4.1958

>AT191824 WP_000587619.1 NZ_CP069799:c2536541-2536284 [Staphylococcus aureus]
MIITSPTEARKDFYQLLKNVNNNHEPIYISGNNAENNAVIIGLEDWKSIQETMYLVSTGTMDKVREREKDSSGTTNIDDI
DWDNL

Download         Length: 258 bp

>AT191824 NZ_CP091925:c3675769-3675395 [Escherichia coli]
GTGTCAGACAAACTCTCCGGGATAACTCATCCCGACGACAATCACGACCGCCCCTGGTGGGGGCTTCCCTGCACAGTGAG
GCCCTGTTTTGGCGCCCGTCTGGTGCAGGAGGGTAACCGCCTGCATTACCTTGCCGACCGCGCCGGTATCAGAGGCCGGT
TCAGAGATGCAGATGCGTACCACCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTGAATCCCCGACATCAGCATACCGTCACGCTGTATGCAAAAGGGCTGACCTGCGAAGCCGACACCCTCGGCTCCTG
TGGTTACGTTTATCTGGCTGTTTATCCGACACCGGCACCCGCAACCACCTCATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E1VXK4

Antitoxin

Source ID Structure
AlphaFold DB A0A0E1VMY7

References