Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) SprA2-SprA2AS/-
Location 2504469..2504653 Replicon chromosome
Accession NZ_CP069799
Organism Staphylococcus aureus strain 014S_SA

Toxin (Protein)


Gene name SprA2 Uniprot ID A0A2U0ISP5
Locus tag JS513_RS12585 Protein ID WP_000482652.1
Coordinates 2504546..2504653 (-) Length 36 a.a.

Antitoxin (RNA)


Gene name SprA2AS
Locus tag -
Coordinates 2504469..2504529 (+)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JS513_RS12570 2499980..2500147 - 168 Protein_2431 hypothetical protein -
JS513_RS12575 2500378..2502111 - 1734 WP_031918671.1 ABC transporter ATP-binding protein/permease -
JS513_RS12580 2502136..2503899 - 1764 WP_001064809.1 ABC transporter ATP-binding protein/permease -
- 2504469..2504529 + 61 - - Antitoxin
JS513_RS12585 2504546..2504653 - 108 WP_000482652.1 type I toxin-antitoxin system Fst family toxin Toxin
JS513_RS12590 2504787..2505173 - 387 WP_000779357.1 flippase GtxA -
JS513_RS12595 2505441..2506583 + 1143 WP_001176863.1 glycerate kinase -
JS513_RS12600 2506643..2507302 + 660 WP_000831298.1 membrane protein -
JS513_RS12605 2507484..2508695 + 1212 WP_001192075.1 multidrug effflux MFS transporter -
JS513_RS12610 2508818..2509291 - 474 WP_000456484.1 GyrI-like domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Type I toxin-antitoxin system, toxin Ldr

(1-35)


Sequences

Toxin        


Download         Length: 36 a.a.        Molecular weight: 4011.78 Da        Isoelectric Point: 11.0582

>T191822 WP_000482652.1 NZ_CP069799:c2504653-2504546 [Staphylococcus aureus]
MFNLLINIMTSALSGCLVAFFAHWLRTRNNKKGDK

Download         Length: 108 bp

>T191822 NZ_CP091925:2673168-2673275 [Escherichia coli]
ATGACGCTCGCGCAGTTTGCCATGACTTTCTGGCACGACCTGGCGGCACCGATCCTGGCGGGAATTATTACCGCAGCGAT
TGTCGGCTTGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 61 bp

>AT191822 NZ_CP069799:2504469-2504529 [Staphylococcus aureus]
TACATAATAAATTGAACATCTAAATACACCAAATCCCCTCACTACTGCCATAGTGAGGGGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2U0ISP5

Antitoxin

Download structure file

References