Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-RelB
Location 2479094..2479611 Replicon chromosome
Accession NZ_CP069799
Organism Staphylococcus aureus strain 014S_SA

Toxin (Protein)


Gene name yoeB Uniprot ID T1YC79
Locus tag JS513_RS12450 Protein ID WP_000113262.1
Coordinates 2479094..2479360 (-) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID T1YB60
Locus tag JS513_RS12455 Protein ID WP_000584499.1
Coordinates 2479360..2479611 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JS513_RS12420 2474520..2475056 - 537 WP_000169317.1 GNAT family N-acetyltransferase -
JS513_RS12425 2475289..2476113 - 825 WP_000572040.1 formate/nitrite transporter family protein -
JS513_RS12430 2476330..2476512 - 183 WP_000230294.1 hypothetical protein -
JS513_RS12435 2476596..2477063 - 468 WP_000153344.1 SRPBCC domain-containing protein -
JS513_RS12440 2477249..2478799 - 1551 WP_000727763.1 zinc ABC transporter substrate-binding lipoprotein AdcA -
JS513_RS12445 2478988..2479059 - 72 Protein_2406 hypothetical protein -
JS513_RS12450 2479094..2479360 - 267 WP_000113262.1 Txe/YoeB family addiction module toxin Toxin
JS513_RS12455 2479360..2479611 - 252 WP_000584499.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
JS513_RS12460 2479776..2479877 - 102 WP_001791744.1 hypothetical protein -
JS513_RS12465 2479884..2480483 - 600 WP_000162813.1 DsbA family protein -
JS513_RS12470 2480502..2480864 - 363 WP_000819843.1 DUF4467 domain-containing protein -
JS513_RS12475 2481119..2482369 + 1251 WP_001012227.1 FemA/FemB family glycyltransferase FmhA -
JS513_RS12480 2482466..2483197 - 732 WP_000615461.1 amino acid ABC transporter ATP-binding protein -
JS513_RS12485 2483194..2483913 - 720 WP_000479576.1 amino acid ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(5-88)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-74)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10437.95 Da        Isoelectric Point: 9.9143

>T191821 WP_000113262.1 NZ_CP069799:c2479360-2479094 [Staphylococcus aureus]
MARLNITFSPQAFEDYKYFQQNDKKMVKKINELLKSIDRNGALEGIGKPEKLKSNLTGYYSRRINHEHRLVYTVDDNHIK
IASCKYHY

Download         Length: 267 bp

>T191821 NZ_CP091925:2672633-2672740 [Escherichia coli]
ATGACGCTCGCGCAGTTTGCCATGACTTTCTGGCACGACCTGGCAGCACCGATCCTGGCGGGGATTATTACCGCAGCGAT
TGTCAGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9433.60 Da        Isoelectric Point: 4.3407

>AT191821 WP_000584499.1 NZ_CP069799:c2479611-2479360 [Staphylococcus aureus]
MIIKNYSYARQNLKALMTKVNDDSDMVTVTSTDDKNVVIMSESDYNSMMETLYLQQNPNNAEHLAQSIADLERGKTITKD
IDV

Download         Length: 252 bp

>AT191821 NZ_CP091925:c2672586-2672520 [Escherichia coli]
TGTCTGGTTTCAAGATTAGCCCCCGTTTTGTTGTCAGGTTTTACCTCTCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6L8G
PDB 6L8F
PDB 7CUA
PDB 6L8E

Antitoxin

Source ID Structure
PDB 6L8G
PDB 6L8F
PDB 7BWF
PDB 6L8E
AlphaFold DB T1YB60

References