Detailed information of TA system TA191811

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): sprA1-sprA1AS/-
• Location: 1878137..1878317
• Replicon: chromosome
• Accession: NZ_CP069799
• Organism: Staphylococcus aureus strain 014S_SA

Toxin (Protein)

• Gene name: sprA1
• Uniprot ID: -
• Locus tag: JS513_RS09065
• Protein ID: WP_001801861.1
• Coordinates: 1878137..1878232 (+)
• Length: 32 a.a.

Antitoxin (RNA)

Gene name	sprA1AS
Locus tag	-
Coordinates	1878260..1878317 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
JS513_RS09035	1873299..1873949	+	651	WP_072470537.1	excalibur calcium-binding domain-containing protein	-
JS513_RS09040	1874030..1875025	+	996	WP_000070641.1	DUF4352 domain-containing protein	-
JS513_RS09045	1875100..1875726	+	627	WP_000669026.1	hypothetical protein	-
JS513_RS09050	1875767..1876108	+	342	WP_000627537.1	DUF3969 family protein	-
JS513_RS09055	1876209..1876781	+	573	WP_000414215.1	hypothetical protein	-
JS513_RS09060	1876980..1877992	-	1013	Protein_1782	IS3 family transposase	-
JS513_RS09065	1878137..1878232	+	96	WP_001801861.1	type I toxin-antitoxin system Fst family toxin PepA1	Toxin
-	1878260..1878317	-	58	-	-	Antitoxin
JS513_RS09070	1878355..1878456	+	102	WP_001792025.1	hypothetical protein	-
JS513_RS09075	1878434..1878595	-	162	Protein_1785	transposase	-
JS513_RS09080	1878586..1879080	-	495	Protein_1786	transposase	-
JS513_RS09085	1879532..1880761	-	1230	WP_047230715.1	restriction endonuclease subunit S	-
JS513_RS09090	1880754..1882310	-	1557	WP_000028583.1	type I restriction-modification system subunit M	-
JS513_RS09095	1882475..1882609	-	135	Protein_1789	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	lukD / hlgA / selk	1872541..1913705	41164

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Sequences

Toxin

Protein

• Length: 32 a.a.
• Molecular weight: 3554.32 Da
• Isoelectric Point: 10.4449

>T191811 WP_001801861.1 NZ_CP069799:1878137-1878232 [Staphylococcus aureus]
VMLIFVHIIAPVISGCAIAFFSYWLSRRNTK

Nucleotide

• Length: 96 bp

>T191811 NZ_CP091925:712550-712846 [Escherichia coli]
ATGGAAAAACGCACACCACATACACGTTTGAGTCAGGTTAAAAAACTTGTCAATGCCGGGCAAGTTCGTACAACACGTAG
TGCCCTGTTAAATGCAGATGAGTTAGGTTTGGATTTTGATGGTATGTGTAATGTTATCATTGGATTATCAGAGAGCGACT
TTTATAAAAGCATGACCACCTACTCTGATCATACTATCTGGCAGGATGTTTACAGACCCAGGCTTGTTACAGGCCAGGTT
TATCTTAAAATTACGGTAATTCATGACGTACTGATCGTCTCGTTTAAGGAGAAGTAA

Antitoxin

Nucleotide

• Length: 58 bp

>AT191811 NZ_CP069799:c1878317-1878260 [Staphylococcus aureus]
AACGAAAATAAGTATTTACTTATACACCAATCCCCTCACTATTTGCGGTAGTGAGGGG

Structures

Antitoxin