Detailed information of TA system TA191808

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): TMCS/-
• Location: 1554062..1554641
• Replicon: chromosome
• Accession: NZ_CP069799
• Organism: Staphylococcus aureus strain 014S_SA

Toxin (Protein)

• Gene name: MW1434
• Uniprot ID: A0A4P7P609
• Locus tag: JS513_RS07455
• Protein ID: WP_001025401.1
• Coordinates: 1554396..1554641 (-)
• Length: 82 a.a.

Antitoxin (RNA)

Gene name	MW1433
Locus tag	-
Coordinates	1554062..1554427 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
JS513_RS07415	1550805..1551362	-	558	WP_000645045.1	DUF2815 family protein	-
JS513_RS07420	1551388..1552554	-	1167	WP_000762531.1	DUF2800 domain-containing protein	-
JS513_RS07425	1552551..1552913	-	363	WP_204997613.1	hypothetical protein	-
JS513_RS07430	1552928..1553251	-	324	WP_000174998.1	hypothetical protein	-
JS513_RS07435	1553330..1553491	-	162	WP_001285954.1	DUF1270 domain-containing protein	-
JS513_RS07440	1553504..1553767	-	264	WP_001124160.1	helix-turn-helix domain-containing protein	-
JS513_RS07445	1553792..1554007	-	216	WP_001097552.1	hypothetical protein	-
JS513_RS07450	1554062..1554427	+	366	WP_001128433.1	hypothetical protein	Antitoxin
JS513_RS07455	1554396..1554641	-	246	WP_001025401.1	DUF2829 domain-containing protein	Toxin
JS513_RS07460	1554688..1554927	+	240	WP_001548903.1	hypothetical protein	-
JS513_RS07465	1554924..1555100	-	177	WP_001001356.1	hypothetical protein	-
JS513_RS07470	1555184..1555375	-	192	WP_001115060.1	helix-turn-helix domain-containing protein	-
JS513_RS07475	1555536..1555865	+	330	WP_204997614.1	helix-turn-helix domain-containing protein	-
JS513_RS07480	1555878..1556339	+	462	WP_000525000.1	hypothetical protein	-
JS513_RS07485	1556357..1556791	+	435	WP_000755718.1	hypothetical protein	-
JS513_RS07490	1556820..1557215	+	396	WP_000449655.1	hypothetical protein	-
JS513_RS07495	1557305..1557451	+	147	WP_001795334.1	hypothetical protein	-
JS513_RS07500	1557448..1558062	-	615	WP_000191466.1	hypothetical protein	-
JS513_RS07505	1558188..1559393	+	1206	WP_000264751.1	site-specific integrase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	lukF-PV / lukS-PV	1513180..1569924	56744

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Protein of unknown function DUF2829 (2-69)

Sequences

Toxin

Protein

• Length: 82 a.a.
• Molecular weight: 9468.72 Da
• Isoelectric Point: 5.7783

>T191808 WP_001025401.1 NZ_CP069799:c1554641-1554396 [Staphylococcus aureus]
MNIQEATKIATKNLVSMTRKDWKESHRTKILPTNDSFLQCIISNSDGTNLIRYWQPSADDLMANDWEVINPTRDQELLKQ
F

Nucleotide

• Length: 246 bp

>T191808 NZ_CP091925:182016-182123 [Escherichia coli]
ATGACGTTCGCAGAGCTGGGCATGGCCTTCTGGCATGATTTAGCGGCTCCGGTCATTGCTGGCATTCTTGCCAGTATGAT
CGTGAACTGGCTGAACAAGCGGAAGTAA

Antitoxin

Nucleotide

• Length: 366 bp

>AT191808 NZ_CP069799:1554062-1554427 [Staphylococcus aureus]
ATGCCCTTGATATCTGATGAATTTGATACACTTACTAAAGACCAACAATATATCTTGTCCGTACTCTACAAAGATTATTT
AGAATGTGTAAAGTTAGGTTCGGTTAAATTAACCTGCAATAATTTTGGAAGTGCTAAAGATATACATACAAAGTATTTTC
AAAAACTACATTTCGAAGATGTAAAATACGATTTAAATAAACTTAAAAACTCTGGGTTCCTAAACGGCGTGTATGCTAGT
AACACTATTTATCATGTAACAATTTCAGACAAGACTGTTGTTTACTTTGAAAATGAGTTTAAAAACAATTTAAAAAGTAT
CATTGATAGCATTTCTAAAATTGCTTCAATAATTCCTGGTCTCTAG

Structures

Toxin

• AlphaFold DB: A0A4P7P609

Antitoxin