Detailed information of TA system TA191796

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): yefM-yoeB (relBE)/YoeB-RelB
• Location: 54338..54858
• Replicon: chromosome
• Accession: NZ_CP069798
• Organism: Paralysiella testudinis strain 26B

Toxin (Protein)

• Gene name: yoeB
• Uniprot ID: -
• Locus tag: JQU52_RS00245
• Protein ID: WP_230339216.1
• Coordinates: 54598..54858 (+)
• Length: 87 a.a.

Antitoxin (Protein)

• Gene name: yefM
• Uniprot ID: -
• Locus tag: JQU52_RS00240
• Protein ID: WP_230339215.1
• Coordinates: 54338..54586 (+)
• Length: 83 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
JQU52_RS00205 (JQU52_00205)	49365..49637	-	273	WP_230339212.1	cell division protein FtsL	-
JQU52_RS00210 (JQU52_00210)	49630..50592	-	963	WP_230339213.1	16S rRNA (cytosine(1402)-N(4))-methyltransferase RsmH	-
JQU52_RS00215 (JQU52_00215)	50589..51044	-	456	WP_230340612.1	division/cell wall cluster transcriptional repressor MraZ	-
JQU52_RS00220 (JQU52_00220)	51366..52520	+	1155	WP_230339214.1	SAM-dependent methyltransferase	-
JQU52_RS00230 (JQU52_00230)	53031..53273	-	243	Protein_44	tyrosine-type recombinase/integrase	-
JQU52_RS00235 (JQU52_00235)	53397..54055	-	659	Protein_45	transposase	-
JQU52_RS00240 (JQU52_00240)	54338..54586	+	249	WP_230339215.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
JQU52_RS00245 (JQU52_00245)	54598..54858	+	261	WP_230339216.1	Txe/YoeB family addiction module toxin	Toxin
JQU52_RS00250 (JQU52_00250)	55089..55448	+	360	WP_230339217.1	EamA family transporter	-
JQU52_RS00255 (JQU52_00255)	55470..55970	+	501	WP_230339218.1	DMT family transporter	-
JQU52_RS00260 (JQU52_00260)	56578..56853	+	276	Protein_50	transposase	-
JQU52_RS00265 (JQU52_00265)	56953..57234	+	282	WP_230339219.1	hypothetical protein	-
JQU52_RS00270 (JQU52_00270)	57259..57768	+	510	WP_230339220.1	winged helix-turn-helix domain-containing protein	-
JQU52_RS00275	57834..58309	+	476	Protein_53	IS630 family transposase	-
JQU52_RS00280 (JQU52_00285)	58577..58798	+	222	WP_230339221.1	hypothetical protein	-
JQU52_RS00285 (JQU52_00290)	58888..59653	+	766	Protein_55	IS5 family transposase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	flank	IS/Tn	-	-	59384..59653	269

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin YoeB (1-84)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (3-75)

Sequences

Toxin

Protein

• Length: 87 a.a.
• Molecular weight: 10372.98 Da
• Isoelectric Point: 10.4647

>T191796 WP_230339216.1 NZ_CP069798:54598-54858 [Paralysiella testudinis]
MQHRFTASAAEDFQYWMKHDQKKVERIKILVADIKQNHPRGIGKPEPLKHQKQGLWSQRIDREHRLVHAIEDRILTIYAC
RFHYGK

Nucleotide

• Length: 261 bp

>T191796 NZ_CP091907:36680-36970 [Enterococcus faecalis]
ATGGCGAATATTACTGACTTCACCGAAAAGCAATTTGAAGATCGTTTAGAAAAGAATGTTGAACGACTAACTAAAAATAG
ACTAGCGGTTGAATCGCCAACCGCTTTTTTACTTGGTGGGCAACCAGGGTCAGGGAAAACCAGTTTGCGATCAGCAATTT
TTGAAGAAACACAAGGGAATGTTATTGTCATTGATAATGATACCTTTAAACAACAGCACCCAAATTTTGACGAATTAGTG
AAACGGTTCTGTTGCAAAGTTTTAAATCTACTATCAAATAAGGTAGAATAA

Antitoxin

Protein

• Length: 83 a.a.
• Molecular weight: 9426.68 Da
• Isoelectric Point: 4.4607

>AT191796 WP_230339215.1 NZ_CP069798:54338-54586 [Paralysiella testudinis]
VDKVISYTSVRENLAQVMNDVCNDKIITHITRRNGENCVLMSEEEYMSMCETLYLFGNPANARHLEKSLQEAEEGKFVQI
DL

Nucleotide

• Length: 249 bp

>AT191796 NZ_CP091907:36406-36678 [Enterococcus faecalis]
ATGGCAGTTACGTATGAAAAAACATTTGAAATTGAAATCATTAATGAGTTATCGGCAAGTGTTTATAATCGGGTATTAAA
TTATGTTTTGAATCATGAACTAGATACTAAAAATACTCGTTTACTAGAAGTGAATCTTTTAAATCAATTAGAAGTGGCAC
AAGAAGTTGATTTATTTCAACAACCATTTGAAGAATTACAAGCTATTCATGAGTATTGGCGGTCAATGAATCAATATTCA
AAACAAATTTTGAATAAAGAGAAAGTGGCTTAA