Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-YefM
Location 1829708..1830210 Replicon chromosome
Accession NZ_CP069712
Organism Escherichia coli strain EA13

Toxin (Protein)


Gene name yoeB Uniprot ID -
Locus tag JSQ77_RS08620 Protein ID WP_106631568.1
Coordinates 1829956..1830210 (+) Length 85 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID S1Q063
Locus tag JSQ77_RS08615 Protein ID WP_001259255.1
Coordinates 1829708..1829959 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JSQ77_RS08590 1824886..1825953 - 1068 WP_029397756.1 bifunctional histidinol-phosphatase/imidazoleglycerol-phosphate dehydratase HisB -
JSQ77_RS08595 1825953..1827023 - 1071 WP_087899531.1 histidinol-phosphate transaminase -
JSQ77_RS08600 1827020..1828324 - 1305 WP_032177449.1 histidinol dehydrogenase -
JSQ77_RS08605 1828330..1829229 - 900 WP_000131782.1 ATP phosphoribosyltransferase -
JSQ77_RS08610 1829375..1829425 - 51 WP_001364200.1 his operon leader peptide -
JSQ77_RS08615 1829708..1829959 + 252 WP_001259255.1 YoeB-YefM toxin-antitoxin system antitoxin YefM Antitoxin
JSQ77_RS08620 1829956..1830210 + 255 WP_106631568.1 type II toxin-antitoxin system mRNA interferase toxin YoeB Toxin
JSQ77_RS08625 1830293..1831117 + 825 WP_000754763.1 SDR family oxidoreductase -
JSQ77_RS08630 1831163..1832092 + 930 WP_000803351.1 LysR family transcriptional regulator -
JSQ77_RS08635 1832307..1832369 + 63 WP_010723108.1 membrane protein YoeI -
JSQ77_RS08640 1832359..1833717 + 1359 WP_000019197.1 putrescine/proton symporter PlaP -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(5-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-73)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 10140.56 Da        Isoelectric Point: 7.2749

>T191749 WP_106631568.1 NZ_CP069712:1829956-1830210 [Escherichia coli]
VKLIWSEESWDDYLYWQETDKRIVKKINELIKDTLRTPFEGKGKPEPLKHNLSGFWSRRITEEHRLVYAVTDDSLLIAAC
RYHY

Download         Length: 255 bp

>T191749 NZ_CP091897:614561-614677 [Enterococcus faecalis]
ATGTTTTTGTCCGTTGAAGCAGCGCTAGGACTGATGATTGGTTTTGCAACACTTGTTGTGACCATTATCTTCGGTATCTT
AGCGCTTGTCTTAGACAACAAAAATAACCGTTCATAA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9307.58 Da        Isoelectric Point: 4.7954

>AT191749 WP_001259255.1 NZ_CP069712:1829708-1829959 [Escherichia coli]
MRTISYSEARQNLSATMMKAVEDHAPILITRQNGEACVLMSLEEYNSLEETAYLLRSPANARRLMDSIDSLKSGKGTEKD
IIE

Download         Length: 252 bp

>AT191749 NZ_CP091897:c614793-614588 [Enterococcus faecalis]
AAAAGAGAGATATGCAGGAACATACCTCTCTAATAGCCACTACTAGTTATAAGAACTAGCGGCTTACTGAGTTATTGGTT
TTATTTCAAACGCTTAACCGTTCAGCTCCTCAAAGCTTATGAACGGTTATTTTTGTTGTCTAAGACAAGCGCTAAGATAC
CGAAGATAATGGTCACAACAAGTGTTGCAAAACCAATCATCAGTCC

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
PDB 2A6Q
AlphaFold DB A0A7U9LNR0

References