Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mqsRA (relBE)/MqsR-MqsA
Location 767058..767751 Replicon chromosome
Accession NZ_CP069712
Organism Escherichia coli strain EA13

Toxin (Protein)


Gene name mqsR Uniprot ID S1EZG2
Locus tag JSQ77_RS03690 Protein ID WP_000415584.1
Coordinates 767058..767354 (+) Length 99 a.a.

Antitoxin (Protein)


Gene name mqsA Uniprot ID S1EBV2
Locus tag JSQ77_RS03695 Protein ID WP_000650107.1
Coordinates 767356..767751 (+) Length 132 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JSQ77_RS03655 762146..762460 - 315 WP_000958598.1 antibiotic biosynthesis monooxygenase -
JSQ77_RS03660 762491..763072 - 582 WP_000065430.1 NADPH:quinone oxidoreductase MdaB -
JSQ77_RS03665 763391..763723 + 333 WP_000917684.1 DUF2645 family protein -
JSQ77_RS03670 763769..765118 - 1350 WP_001618857.1 two-component system sensor histidine kinase QseC -
JSQ77_RS03675 765115..765774 - 660 WP_001221493.1 two-component system response regulator QseB -
JSQ77_RS03680 765926..766318 + 393 WP_000712658.1 OB fold stress tolerance protein YgiW -
JSQ77_RS03685 766371..766853 + 483 WP_000183505.1 transcriptional regulator -
JSQ77_RS03690 767058..767354 + 297 WP_000415584.1 type II toxin-antitoxin system toxin MqsR Toxin
JSQ77_RS03695 767356..767751 + 396 WP_000650107.1 type II toxin-antitoxin system antitoxin MqsA Antitoxin
JSQ77_RS03700 767884..769491 + 1608 WP_088213289.1 ABC transporter substrate-binding protein -
JSQ77_RS03705 769629..771887 + 2259 WP_088213288.1 DNA topoisomerase IV subunit A -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase toxin MqsR

(5-97)

Antitoxin

Zinc finger, MqsA-type

(3-47)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 11231.96 Da        Isoelectric Point: 8.9070

>T191745 WP_000415584.1 NZ_CP069712:767058-767354 [Escherichia coli]
MEKRTPHTRLSQVKKLVNAGQVRTTRSALLNADELGLDFDGMCNVIIGLSESDFYKSMTTYSDHTIWQDVYRPRLVTGQV
YLKITVIHDVLIVSFKEK

Download         Length: 297 bp

>T191745 NZ_CP091895:c2778635-2778294 [Enterococcus faecalis]
ATGAATGTTGAAAAGAAGTACATTCCCAAAAAAGGAGATATTGTATGGATTGATTTTGATCCTGCTGCAGGTAAAGAAAT
TCAGAAGAGACGCCCTGGTTTAGTCGTGTCAAGATATGAATTTAATCGGAAAACCATGTTTGCTGTGATTTGCCCGATTA
CTTCCACCATTAAAAATATTCCCACTCGATATACGTTGCCCGATGACATAGAAACCCAAGGACAAGTAGTGATCTCACAA
CTGAAATCTTTGGACTTCACTGAAAGAAAATTAAGTCAAATTGAGCATTTGCCATTAAAAGATATGGCGAAAATTGACCA
AATAATTGAATATATTTTCTAG

Antitoxin


Download         Length: 132 a.a.        Molecular weight: 14703.10 Da        Isoelectric Point: 9.2136

>AT191745 WP_000650107.1 NZ_CP069712:767356-767751 [Escherichia coli]
MKCPVCHQGEMVSGIKDIPYTFRGRKTVLKGIHGLYCVHCEESIMNKEESDAFMAQVKAFRASVNAETVAPEFIVKVRKK
LSLTQKEASEIFGGGVNAFSRYEKGNAQPHPSTIKLLRVLDKHPELLNEIR

Download         Length: 396 bp

>AT191745 NZ_CP091895:c2778865-2778635 [Enterococcus faecalis]
ATGCTAACAACTAAATCAAGAAGACAAGGAAGCTCGGTCGTTTTAACTTTACCCACTGATAATGGTAAAAAACCAAAAGT
CGACCAAGAATATATTGTGATGTATTCTGACGACGGTACAATTACATTAGTCCCTAAAATTCAGGATCCATTTAGTGAAG
GTCCAGAAGGTGAGTATTATGAAAAAGATGAGTGGCATGATCTTGCACCTGAGGGGAGAGAACTTTTTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 3HI2

Antitoxin

Source ID Structure
PDB 3HI2
PDB 3GA8
PDB 3O9X
PDB 2KZ8
PDB 3FMY
PDB 3GN5
AlphaFold DB A0A7U9LU65

References