Detailed information of TA system TA191738

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): hok-sok/-
• Location: 3775210..3775468
• Replicon: chromosome
• Accession: NZ_CP069710
• Organism: Escherichia coli strain EA2

Toxin (Protein)

• Gene name: hokC
• Uniprot ID: S1NX00
• Locus tag: JSQ74_RS18075
• Protein ID: WP_000809168.1
• Coordinates: 3775210..3775362 (-)
• Length: 51 a.a.

Antitoxin (RNA)

Gene name	sokC
Locus tag	-
Coordinates	3775411..3775468 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
JSQ74_RS18055	3770451..3771164	-	714	WP_001102383.1	acidic protein MsyB	-
JSQ74_RS18060	3771190..3771594	-	405	WP_000843568.1	DUF2541 family protein	-
JSQ74_RS18065	3771971..3773887	+	1917	WP_000516135.1	molecular chaperone DnaK	-
JSQ74_RS18070	3773976..3775106	+	1131	WP_001118464.1	molecular chaperone DnaJ	-
JSQ74_RS18075	3775210..3775362	-	153	WP_000809168.1	type I toxin-antitoxin system toxin MokC	Toxin
-	3775411..3775468	+	58	-	-	Antitoxin
JSQ74_RS18080	3775948..3777114	+	1167	WP_000681368.1	Na+/H+ antiporter NhaA	-
JSQ74_RS18085	3777180..3778079	+	900	WP_001300855.1	transcriptional activator NhaR	-
JSQ74_RS18090	3778117..3779076	-	960	WP_000871671.1	hypothetical protein	-
JSQ74_RS18095	3779089..3780441	-	1353	Protein_3529	fimbria/pilus outer membrane usher protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Hok/gef cell toxic protein (6-47)

Sequences

Toxin

Protein

• Length: 51 a.a.
• Molecular weight: 5501.57 Da
• Isoelectric Point: 7.1312

>T191738 WP_000809168.1 NZ_CP069710:c3775362-3775210 [Escherichia coli]
MKQHKAMIVALIVICITAVVAALVTRKDLCEVHIRTGQTEVAVFTAYESE

Nucleotide

• Length: 153 bp

>T191738 NZ_CP091893:146485-146826 [Enterococcus faecalis]
ATGAGTGACGAAAAGAAATATATTCCTAAAAAGGGCGATATTGTATGGATAGATTTCGATCCTTCAGCTGAAAAAGAAAT
ACAGAAAAGACGTCCAGGTCTAGTAGTTTCTAGATATGAGTTTAATAGAAAGACATTGTTTGCAGTAATTTGTCCCATAA
CTTCTACAATTAAAAATATGCCAACTCGTTATACATTACCTGATGAAATGGAAACTCATGGACAAGTCGTTATTTCCCAA
TTAAAATCTTTAGACTTTGCAGAAAGAAAGTTAAGCCAAATAGAATATTTACCATTAAAGGATATGGCTAAAATAGATCA
AATCATTGAATACATTTTTTAA

Antitoxin

Nucleotide

• Length: 58 bp

>AT191738 NZ_CP069710:3775411-3775468 [Escherichia coli]
GTTCAGCATATAGGGGGCCTCGGGTTGATGGTAAAATATCACTCGGGGCTTTTCTCTA

Structures

Toxin

• AlphaFold DB: S1NX00

Antitoxin