Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mqsRA (relBE)/MqsR-MqsA
Location 2260274..2260967 Replicon chromosome
Accession NZ_CP069710
Organism Escherichia coli strain EA2

Toxin (Protein)


Gene name mqsR Uniprot ID S1EZG2
Locus tag JSQ74_RS10855 Protein ID WP_000415584.1
Coordinates 2260671..2260967 (-) Length 99 a.a.

Antitoxin (Protein)


Gene name mqsA Uniprot ID S1EBV2
Locus tag JSQ74_RS10850 Protein ID WP_000650107.1
Coordinates 2260274..2260669 (-) Length 132 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JSQ74_RS10840 2256138..2258396 - 2259 WP_001281881.1 DNA topoisomerase IV subunit A -
JSQ74_RS10845 2258534..2260141 - 1608 WP_204084400.1 ABC transporter substrate-binding protein -
JSQ74_RS10850 2260274..2260669 - 396 WP_000650107.1 type II toxin-antitoxin system antitoxin MqsA Antitoxin
JSQ74_RS10855 2260671..2260967 - 297 WP_000415584.1 type II toxin-antitoxin system toxin MqsR Toxin
JSQ74_RS10860 2261172..2261654 - 483 WP_000183494.1 transcriptional regulator -
JSQ74_RS10865 2261707..2262099 - 393 WP_000712658.1 OB fold stress tolerance protein YgiW -
JSQ74_RS10870 2262251..2262910 + 660 WP_001221503.1 two-component system response regulator QseB -
JSQ74_RS10875 2262907..2264256 + 1350 WP_151317648.1 two-component system sensor histidine kinase QseC -
JSQ74_RS10880 2264302..2264634 - 333 WP_000914690.1 DUF2645 family protein -
JSQ74_RS10885 2264641..2265833 - 1193 Protein_2135 Hcp family type VI secretion system effector -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase toxin MqsR

(5-97)

Antitoxin

Zinc finger, MqsA-type

(3-47)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 11231.96 Da        Isoelectric Point: 8.9070

>T191733 WP_000415584.1 NZ_CP069710:c2260967-2260671 [Escherichia coli]
MEKRTPHTRLSQVKKLVNAGQVRTTRSALLNADELGLDFDGMCNVIIGLSESDFYKSMTTYSDHTIWQDVYRPRLVTGQV
YLKITVIHDVLIVSFKEK

Download         Length: 297 bp

>T191733 NZ_CP091892:c2713789-2713646 [Enterococcus faecalis]
ATGAGCGTACTTCCAAAATTTACGGAAAGGAGAGGCCTTTTGTCAGCATATGAAACAATTCAGACGATCCTAGGGTTTGG
TATGTTTACCATTGCTTTGATTGCACTGATTGTGAAATTGCTTAAAAATGACAATAAAAAATAA

Antitoxin


Download         Length: 132 a.a.        Molecular weight: 14703.10 Da        Isoelectric Point: 9.2136

>AT191733 WP_000650107.1 NZ_CP069710:c2260669-2260274 [Escherichia coli]
MKCPVCHQGEMVSGIKDIPYTFRGRKTVLKGIHGLYCVHCEESIMNKEESDAFMAQVKAFRASVNAETVAPEFIVKVRKK
LSLTQKEASEIFGGGVNAFSRYEKGNAQPHPSTIKLLRVLDKHPELLNEIR

Download         Length: 396 bp

>AT191733 NZ_CP091892:2713527-2713672 [Enterococcus faecalis]
TGTGCTATAATGAAAACGAAAAGAGAGATATGCTTCAACATACCTCTCTGATGTAGAGCCGTTTAAGACGGTGACCGATT
GTATTATTTAAAAATAACCGTACTGGTCAAAGTAGACGGTTATTTTTTATTGTCATTTTTAAGCAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 3HI2

Antitoxin

Source ID Structure
PDB 3HI2
PDB 3GA8
PDB 3O9X
PDB 2KZ8
PDB 3FMY
PDB 3GN5
AlphaFold DB A0A7U9LU65

References