Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mqsRA (relBE)/MqsR-MqsA
Location 738561..739254 Replicon chromosome
Accession NZ_CP069707
Organism Escherichia coli strain E41

Toxin (Protein)


Gene name mqsR Uniprot ID S1EZG2
Locus tag JSQ86_RS03635 Protein ID WP_000415584.1
Coordinates 738561..738857 (+) Length 99 a.a.

Antitoxin (Protein)


Gene name mqsA Uniprot ID S1EBV2
Locus tag JSQ86_RS03640 Protein ID WP_000650107.1
Coordinates 738859..739254 (+) Length 132 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JSQ86_RS03600 733649..733963 - 315 WP_000958598.1 antibiotic biosynthesis monooxygenase -
JSQ86_RS03605 733994..734575 - 582 WP_000065430.1 NADPH:quinone oxidoreductase MdaB -
JSQ86_RS03610 734894..735226 + 333 WP_113078367.1 DUF2645 family protein -
JSQ86_RS03615 735272..736621 - 1350 WP_000673402.1 two-component system sensor histidine kinase QseC -
JSQ86_RS03620 736618..737277 - 660 WP_001221493.1 two-component system response regulator QseB -
JSQ86_RS03625 737429..737821 + 393 WP_000712658.1 OB fold stress tolerance protein YgiW -
JSQ86_RS03630 737874..738356 + 483 WP_000183505.1 transcriptional regulator -
JSQ86_RS03635 738561..738857 + 297 WP_000415584.1 type II toxin-antitoxin system toxin MqsR Toxin
JSQ86_RS03640 738859..739254 + 396 WP_000650107.1 type II toxin-antitoxin system antitoxin MqsA Antitoxin
JSQ86_RS03645 739387..740994 + 1608 WP_113078366.1 ABC transporter substrate-binding protein -
JSQ86_RS03650 741132..743390 + 2259 WP_001281881.1 DNA topoisomerase IV subunit A -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase toxin MqsR

(5-97)

Antitoxin

Zinc finger, MqsA-type

(3-47)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 11231.96 Da        Isoelectric Point: 8.9070

>T191681 WP_000415584.1 NZ_CP069707:738561-738857 [Escherichia coli]
MEKRTPHTRLSQVKKLVNAGQVRTTRSALLNADELGLDFDGMCNVIIGLSESDFYKSMTTYSDHTIWQDVYRPRLVTGQV
YLKITVIHDVLIVSFKEK

Download         Length: 297 bp

>T191681 NZ_CP091878:c4134236-4133928 [Salmonella enterica subsp. enterica serovar Tennessee]
ATGCAATACATGGTTTATCGCAATAAAGGAAACAGCAAGGCTTATCCTTATTTACTTGATGTGCAAAGCGATATTATTGA
TGAACTGCATACTCGCATGGTTATCCCATTGTTTCCTGTGAGCAGGTTGGTAAATAACCCAGTTAAGCGTCTCACGCCCA
CTCTGAATGTGGAAGGTAATGACTATCTGGTGATGACTCACGAAATGGCGAGTATCAGGCTTTCGCAGATTGGTGATGAG
GTGATGGACGTTCGTTCCCACAGGCAAACCATCAAAAATGCTCTCGATTTTATCTTTGACGGGTTCTGA

Antitoxin


Download         Length: 132 a.a.        Molecular weight: 14703.10 Da        Isoelectric Point: 9.2136

>AT191681 WP_000650107.1 NZ_CP069707:738859-739254 [Escherichia coli]
MKCPVCHQGEMVSGIKDIPYTFRGRKTVLKGIHGLYCVHCEESIMNKEESDAFMAQVKAFRASVNAETVAPEFIVKVRKK
LSLTQKEASEIFGGGVNAFSRYEKGNAQPHPSTIKLLRVLDKHPELLNEIR

Download         Length: 396 bp

>AT191681 NZ_CP091878:c4134478-4134239 [Salmonella enterica subsp. enterica serovar Tennessee]
ATGTCGGGTATGAGTGTACGACATAAAAAAACAGTCAGTGTCACGCTGGAACCTGCATTGCTTCAGCAAGCCCGTGATGC
AGGTATTAATCTGTCTGCGGTGCTTACCGCTGCGCTGAAAGAGGAAATCAGTGCCACAGACGTTGAACGCTGGAAAGCAG
AAAATAGAGCGGGTTTGCAGGAGCTCAATCGTATTACTGATGAGCACGGCCTTTTATCGGACGATTACAGGACGTTTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 3HI2

Antitoxin

Source ID Structure
PDB 3HI2
PDB 3GA8
PDB 3O9X
PDB 2KZ8
PDB 3FMY
PDB 3GN5
AlphaFold DB A0A7U9LU65

References