Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) prlF-yhaV (relBE)/YhaV-PrlF
Location 628344..629143 Replicon chromosome
Accession NZ_CP069707
Organism Escherichia coli strain E41

Toxin (Protein)


Gene name yhaV Uniprot ID S1NYM6
Locus tag JSQ86_RS03075 Protein ID WP_000347251.1
Coordinates 628344..628808 (-) Length 155 a.a.

Antitoxin (Protein)


Gene name prlF Uniprot ID S1EB98
Locus tag JSQ86_RS03080 Protein ID WP_001307405.1
Coordinates 628808..629143 (-) Length 112 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JSQ86_RS03045 623345..623779 - 435 WP_000948824.1 PTS sugar transporter subunit IIA -
JSQ86_RS03050 623797..624675 - 879 WP_001300474.1 PTS system mannose/fructose/sorbose family transporter subunit IID -
JSQ86_RS03055 624665..625444 - 780 WP_113078703.1 PTS mannose/fructose/sorbose/N-acetylgalactosamine transporter subunit IIC -
JSQ86_RS03060 625455..625928 - 474 WP_001295547.1 PTS N-acetylgalactosamine transporter subunit IIB -
JSQ86_RS03065 625951..627231 - 1281 WP_000681903.1 tagatose-bisphosphate aldolase subunit KbaZ -
JSQ86_RS03070 627480..628289 + 810 WP_000072187.1 aga operon transcriptional regulator AgaR -
JSQ86_RS03075 628344..628808 - 465 WP_000347251.1 type II toxin-antitoxin system ribonuclease toxin YhaV Toxin
JSQ86_RS03080 628808..629143 - 336 WP_001307405.1 type II toxin-antitoxin system antitoxin PrlF Antitoxin
JSQ86_RS03085 629292..630863 - 1572 WP_097463558.1 galactarate dehydratase -
JSQ86_RS03090 631238..632572 + 1335 WP_113078704.1 galactarate/glucarate/glycerate transporter GarP -
JSQ86_RS03095 632588..633358 + 771 WP_001058209.1 2-dehydro-3-deoxyglucarate aldolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin endonuclease, YhaV

(12-150)

Antitoxin

PrlF antitoxin

(14-110)


Sequences

Toxin        


Download         Length: 155 a.a.        Molecular weight: 17777.14 Da        Isoelectric Point: 9.4947

>T191679 WP_000347251.1 NZ_CP069707:c628808-628344 [Escherichia coli]
MDFPQRVNGWALYAHPCFQETYDALVAEVEALKGKDPENYQRKAATKLLAVVHKVIEEHITVNPSSPAFRHGKSLGSGKN
KDWSRVKFGAGRYRLFFRYSEKEKVIILGWMNDENTLRTYGKKTDAYTVFSKMLKRGHPPADWESLTQETEENH

Download         Length: 465 bp

>T191679 NZ_CP091878:3470174-3470392 [Salmonella enterica subsp. enterica serovar Tennessee]
ATGTCTGATAAACCATTAACTAAAACTGATTATTTGATGCGTTTACGGCGCTGTCAGACAATTGACACTCTGGAGCGCGT
CATTGAGAAAAATAAATATGAATTGTCCGACAATGAGCTGGCTGTATTTTACTCAGCTGCGGATCACCGTCTTGCAGAAT
TGACGATGAACAAACTCTACGACAAGATCCCCTCTTCAGTATGGAAATTCATTCGTTAA

Antitoxin


Download         Length: 112 a.a.        Molecular weight: 12358.94 Da        Isoelectric Point: 4.8616

>AT191679 WP_001307405.1 NZ_CP069707:c629143-628808 [Escherichia coli]
MPANARSHAVLTTESKVTIRGQTTIPAPVREALKLKPGQDSIHYEILPGGQVFMCRLGDEQEDHTMNAFLRFLDADIQNN
PQKTRPFNIQQGKKLVAGMDVNIDDEIGDDE

Download         Length: 336 bp

>AT191679 NZ_CP091878:3469772-3470146 [Salmonella enterica subsp. enterica serovar Tennessee]
ATGGACGAATACTCACCCAAAAGACATGATATAGCACAGCTTAAATTTCTTTGCGAAACCCTGTATCATGACTGTCTTGC
AAACCTTGAAGAAAGCAACCATGGCTGGGTTAATGACCCGACCTCAGCAGTCAACCTGCAGCTCAATGAGCTGATAGAGC
ATATTGCAACTTTCGCGCTTAATTATAAAATTAAGTACAATGAAGACAATAAATTGATTGCGCAGATAGATGAATACCTG
GACGACACCTTTATGTTGTTCAGCAGCTATGGTATTAATACGCAGGATTTGCAAAAATGGCGTAAATCGGGCAACCGCCT
GTTCCGTTGTTTCGTCAACGCCACCAGGGCTAATCCTGTTAGTTTGTCTTGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829CJ20

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0XVC7

References