Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-YefM
Location 1754102..1754604 Replicon chromosome
Accession NZ_CP069706
Organism Escherichia coli strain ECY44

Toxin (Protein)


Gene name yoeB Uniprot ID V0THH9
Locus tag JR341_RS11470 Protein ID WP_023141665.1
Coordinates 1754350..1754604 (+) Length 85 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID S1Q063
Locus tag JR341_RS11465 Protein ID WP_001259255.1
Coordinates 1754102..1754353 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JR341_RS11440 1749280..1750347 - 1068 WP_000080093.1 bifunctional histidinol-phosphatase/imidazoleglycerol-phosphate dehydratase HisB -
JR341_RS11445 1750347..1751417 - 1071 WP_096976785.1 histidinol-phosphate transaminase -
JR341_RS11450 1751414..1752718 - 1305 WP_204088880.1 histidinol dehydrogenase -
JR341_RS11455 1752724..1753623 - 900 WP_000131782.1 ATP phosphoribosyltransferase -
JR341_RS11460 1753769..1753819 - 51 WP_001364200.1 his operon leader peptide -
JR341_RS11465 1754102..1754353 + 252 WP_001259255.1 YoeB-YefM toxin-antitoxin system antitoxin YefM Antitoxin
JR341_RS11470 1754350..1754604 + 255 WP_023141665.1 type II toxin-antitoxin system mRNA interferase toxin YoeB Toxin
JR341_RS11475 1754687..1755511 + 825 WP_000754749.1 SDR family oxidoreductase -
JR341_RS11480 1755557..1756486 + 930 WP_000803351.1 LysR family transcriptional regulator -
JR341_RS11485 1756701..1756763 + 63 WP_010723108.1 membrane protein YoeI -
JR341_RS11490 1756753..1758111 + 1359 WP_000019197.1 putrescine/proton symporter PlaP -
JR341_RS11495 1758290..1759348 + 1059 WP_063091615.1 transport protein YeeE -
JR341_RS11500 1759362..1759589 + 228 WP_050867712.1 sulfurtransferase TusA family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(5-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-73)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 10229.67 Da        Isoelectric Point: 7.8733

>T191661 WP_023141665.1 NZ_CP069706:1754350-1754604 [Escherichia coli]
VKLIWSEESWDDYLYWQETDKRIVKKINELIKDTRRTPFECKGKPEPLKHNLSGFWSRRITEEHRLVYAVTDDSLLIAAC
RYHY

Download         Length: 255 bp

>T191661 NZ_CP091875:c2651919-2651812 [Staphylococcus aureus]
ATGTTCAATTTATTAATTGACATCATGACTTCAGCTTTAAGCGGCTGTCTTGTTGCGTTTTTTGCACATTGGTTACGAAC
GCGCAACAATAAAAAAGGTGACAAATAA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9307.58 Da        Isoelectric Point: 4.7954

>AT191661 WP_001259255.1 NZ_CP069706:1754102-1754353 [Escherichia coli]
MRTISYSEARQNLSATMMKAVEDHAPILITRQNGEACVLMSLEEYNSLEETAYLLRSPANARRLMDSIDSLKSGKGTEKD
IIE

Download         Length: 252 bp

>AT191661 NZ_CP091875:2651735-2651795 [Staphylococcus aureus]
TACATAATAAATTGAACATCTAAATACACCAAATCCCCTCACTACTGCCATAGTGAGGGGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB V0THH9

Antitoxin

Source ID Structure
PDB 2A6Q
AlphaFold DB A0A7U9LNR0

References