Detailed information of TA system
Overview
TA module
| Type | I | Classification (family/domain) | hok-sok/- |
| Location | 121477..121903 | Replicon | plasmid pMUB-MIN10-1 |
| Accession | NZ_CP069678 | ||
| Organism | Escherichia coli O126:H45 strain MIN10 | ||
Toxin (Protein)
| Gene name | hok | Uniprot ID | - |
| Locus tag | JSU12_RS25540 | Protein ID | WP_001372321.1 |
| Coordinates | 121477..121602 (-) | Length | 42 a.a. |
Antitoxin (RNA)
| Gene name | sok | ||
| Locus tag | - | ||
| Coordinates | 121679..121903 (-) |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| JSU12_RS25510 (116544) | 116544..116717 | - | 174 | WP_230133086.1 | TraY domain-containing protein | - |
| JSU12_RS25515 (116852) | 116852..117541 | - | 690 | WP_000283385.1 | conjugal transfer transcriptional regulator TraJ | - |
| JSU12_RS25520 (117728) | 117728..118111 | - | 384 | WP_001151524.1 | conjugal transfer relaxosome DNA-binding protein TraM | - |
| JSU12_RS25525 (118443) | 118443..119033 | + | 591 | WP_001376243.1 | transglycosylase SLT domain-containing protein | - |
| JSU12_RS25530 (119330) | 119330..120151 | - | 822 | WP_001234426.1 | DUF932 domain-containing protein | - |
| JSU12_RS25535 (120269) | 120269..120556 | - | 288 | WP_000107535.1 | hypothetical protein | - |
| JSU12_RS26845 (120581) | 120581..120787 | - | 207 | WP_000547968.1 | hypothetical protein | - |
| JSU12_RS26850 (120857) | 120857..121029 | + | 173 | Protein_133 | hypothetical protein | - |
| JSU12_RS26855 (121027) | 121027..121257 | - | 231 | WP_071586998.1 | hypothetical protein | - |
| JSU12_RS25540 (121477) | 121477..121602 | - | 126 | WP_001372321.1 | type I toxin-antitoxin system Hok family toxin | Toxin |
| JSU12_RS26860 (121544) | 121544..121693 | - | 150 | Protein_136 | plasmid maintenance protein Mok | - |
| - (121679) | 121679..121903 | - | 225 | NuclAT_0 | - | Antitoxin |
| - (121679) | 121679..121903 | - | 225 | NuclAT_0 | - | Antitoxin |
| - (121679) | 121679..121903 | - | 225 | NuclAT_0 | - | Antitoxin |
| - (121679) | 121679..121903 | - | 225 | NuclAT_0 | - | Antitoxin |
| JSU12_RS25545 (121715) | 121715..121903 | + | 189 | WP_001299721.1 | hypothetical protein | - |
| JSU12_RS25550 (121872) | 121872..122634 | - | 763 | Protein_138 | plasmid SOS inhibition protein A | - |
| JSU12_RS25555 (122631) | 122631..123065 | - | 435 | WP_000845936.1 | conjugation system SOS inhibitor PsiB | - |
| JSU12_RS25560 (123120) | 123120..123317 | - | 198 | Protein_140 | hypothetical protein | - |
| JSU12_RS25565 (123345) | 123345..123578 | - | 234 | WP_000005987.1 | DUF905 family protein | - |
| JSU12_RS25570 (123646) | 123646..124185 | - | 540 | WP_000290840.1 | single-stranded DNA-binding protein | - |
| JSU12_RS25575 (124211) | 124211..124417 | - | 207 | WP_000275856.1 | hypothetical protein | - |
| JSU12_RS26865 (124487) | 124487..124567 | + | 81 | Protein_144 | hypothetical protein | - |
| JSU12_RS26870 (124750) | 124750..124919 | - | 170 | Protein_145 | hypothetical protein | - |
| JSU12_RS25580 (125556) | 125556..126527 | - | 972 | WP_000817028.1 | ParB/RepB/Spo0J family plasmid partition protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Conjugative plasmid | blaTEM-1B / sul3 / ant(3'')-Ia / dfrA1 / tet(A) / sitABCD | iroB / iroC / iroD / iroE / iroN / iutA / iucD / iucC / iucB / iucA | 1..146908 | 146908 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 42 a.a. Molecular weight: 4780.69 Da Isoelectric Point: 8.5110
>T191605 WP_001372321.1 NZ_CP069678:c121602-121477 [Escherichia coli O126:H45]
VLIVCLTLLIFTYLTRKSLCEIRYRDGHREVAAFMAYESGK
VLIVCLTLLIFTYLTRKSLCEIRYRDGHREVAAFMAYESGK
Download Length: 126 bp
>T191605 NZ_CP091837:c52584-52204 [Escherichia coli]
ATGAGGCATATATCACCGGAAGAACTGATAGCGCTTCATGATGCGAATATAAGCCGCTACGGCGGCCTGCCGGGAATGTC
AGATCCGGGTAGGGCAGAGGCCATTATCGGGAGAGTTCAGGCCAGAGTTGCCTACGAAGAGATCACCGACCTTTTCGAAG
TCTCCGCCACCTACCTGGTGGCTACGGCGAGAGGGCATATATTCAATGATGCCAATAAGCGTACCGCGCTAAACAGTGCG
CTGCTATTTCTACGCCGTAACGGTATACAGGTATATGATTCTCCCGTGCTGGTGGAACTTGCGGTGGGGGCCGCAACTGG
TGAAATCCCCGTATCTTCAGTAGCGGAAAAACTACGTGAATTATTTGGTTCCAATATTTGA
ATGAGGCATATATCACCGGAAGAACTGATAGCGCTTCATGATGCGAATATAAGCCGCTACGGCGGCCTGCCGGGAATGTC
AGATCCGGGTAGGGCAGAGGCCATTATCGGGAGAGTTCAGGCCAGAGTTGCCTACGAAGAGATCACCGACCTTTTCGAAG
TCTCCGCCACCTACCTGGTGGCTACGGCGAGAGGGCATATATTCAATGATGCCAATAAGCGTACCGCGCTAAACAGTGCG
CTGCTATTTCTACGCCGTAACGGTATACAGGTATATGATTCTCCCGTGCTGGTGGAACTTGCGGTGGGGGCCGCAACTGG
TGAAATCCCCGTATCTTCAGTAGCGGAAAAACTACGTGAATTATTTGGTTCCAATATTTGA
Antitoxin
Download Length: 225 bp
>AT191605 NZ_CP069678:c121903-121679 [Escherichia coli O126:H45]
TCACACGGATTTCCCGTGAACGGTCTGAATGAGCGGATTATTTTCAGGGAAAGTGAGTGTGGTCAGCGTGCAGGTATATG
GGCTATGATGTGCCCGGCGCTTGAGGCTTTCTGCCTCATGACGTGAAGGTGGTTTGTTGCCGTGTTGTGTGGCAGAAAGA
AGATAGCCCCGTAGTAAGTTAATTTTCATTAACCACCACGAGGCATCCCTATGTCTAGTCCACAT
TCACACGGATTTCCCGTGAACGGTCTGAATGAGCGGATTATTTTCAGGGAAAGTGAGTGTGGTCAGCGTGCAGGTATATG
GGCTATGATGTGCCCGGCGCTTGAGGCTTTCTGCCTCATGACGTGAAGGTGGTTTGTTGCCGTGTTGTGTGGCAGAAAGA
AGATAGCCCCGTAGTAAGTTAATTTTCATTAACCACCACGAGGCATCCCTATGTCTAGTCCACAT
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
