Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | yefM-yoeB (relBE)/YoeB-YefM |
| Location | 1924693..1925195 | Replicon | chromosome |
| Accession | NZ_CP069677 | ||
| Organism | Escherichia coli O126:H45 strain MIN10 | ||
Toxin (Protein)
| Gene name | yoeB | Uniprot ID | U9YDH0 |
| Locus tag | JSU12_RS09180 | Protein ID | WP_000767829.1 |
| Coordinates | 1924941..1925195 (+) | Length | 85 a.a. |
Antitoxin (Protein)
| Gene name | yefM | Uniprot ID | S1Q063 |
| Locus tag | JSU12_RS09175 | Protein ID | WP_001259255.1 |
| Coordinates | 1924693..1924944 (+) | Length | 84 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| JSU12_RS09150 (1919871) | 1919871..1920938 | - | 1068 | WP_001403117.1 | bifunctional histidinol-phosphatase/imidazoleglycerol-phosphate dehydratase HisB | - |
| JSU12_RS09155 (1920938) | 1920938..1922008 | - | 1071 | WP_071345243.1 | histidinol-phosphate transaminase | - |
| JSU12_RS09160 (1922005) | 1922005..1923309 | - | 1305 | WP_001403116.1 | histidinol dehydrogenase | - |
| JSU12_RS09165 (1923315) | 1923315..1924214 | - | 900 | WP_000131782.1 | ATP phosphoribosyltransferase | - |
| JSU12_RS09170 (1924360) | 1924360..1924410 | - | 51 | WP_001364200.1 | his operon leader peptide | - |
| JSU12_RS09175 (1924693) | 1924693..1924944 | + | 252 | WP_001259255.1 | YoeB-YefM toxin-antitoxin system antitoxin YefM | Antitoxin |
| JSU12_RS09180 (1924941) | 1924941..1925195 | + | 255 | WP_000767829.1 | type II toxin-antitoxin system mRNA interferase toxin YoeB | Toxin |
| JSU12_RS09185 (1925278) | 1925278..1926102 | + | 825 | WP_000754737.1 | SDR family oxidoreductase | - |
| JSU12_RS09190 (1926148) | 1926148..1927077 | + | 930 | WP_063090662.1 | LysR substrate-binding domain-containing protein | - |
| JSU12_RS09195 (1927292) | 1927292..1927354 | + | 63 | WP_010723108.1 | membrane protein YoeI | - |
| JSU12_RS09200 (1927344) | 1927344..1928702 | + | 1359 | WP_000019197.1 | putrescine/proton symporter PlaP | - |
| JSU12_RS09205 (1928881) | 1928881..1929939 | + | 1059 | WP_000492312.1 | thiosulfate utilization transporter TsuA/YeeE | - |
| JSU12_RS09210 (1929953) | 1929953..1930180 | + | 228 | WP_000985278.1 | thiosulfate utilization sulfurtransferase TsuB/YeeD | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 85 a.a. Molecular weight: 10183.58 Da Isoelectric Point: 8.0353
>T191582 WP_000767829.1 NZ_CP069677:1924941-1925195 [Escherichia coli O126:H45]
VKLIWSEESWDDYLYWQETDKRIVKKINELIKDTRRTPFEGKGKPEPLKHNLSGFWSRRITEEHRLVYAVTDDSLLIAAC
RYHY
VKLIWSEESWDDYLYWQETDKRIVKKINELIKDTRRTPFEGKGKPEPLKHNLSGFWSRRITEEHRLVYAVTDDSLLIAAC
RYHY
Download Length: 255 bp
>T191582 NZ_CP091833:1377447-1377887 [Shewanella xiamenensis]
GTGGCCGAGCTGCGCCATAGTTTTAGTGTAAAAGCCTCCTTTGACCAACGTCTCTCGTTGGTCGTATTTGTTTGTGTCTG
TAGCACTTCTTTACTTCTCTGGCCAGAAACGGATACCGCAGTACTACATGGACTGAGGGCTATATTCGCCGTCTTAATAT
TGGGATTCTTGTGCTCTCAGTTATGGCAACTGAGGAAATGGCATTACCGTTTTGAGCTTAATGGTCAAGGAGAAGGCTGG
CTATCAACGGGAGAGGCGTTTCACGTATTGCAAAGAACTTGGGTAACGCCGTTTATCTGCTTGGTTTACTATCAATCTGC
CGATAGGTTGCATCTCTTACCTCTATGGGCGGATATGTTTAGTGATACAGATTATCGCCACTTGTGCCGGCTATTACTTA
AAGTTAAAACTCAGGCGGTGAGCCAACACGAACTACTTTAA
GTGGCCGAGCTGCGCCATAGTTTTAGTGTAAAAGCCTCCTTTGACCAACGTCTCTCGTTGGTCGTATTTGTTTGTGTCTG
TAGCACTTCTTTACTTCTCTGGCCAGAAACGGATACCGCAGTACTACATGGACTGAGGGCTATATTCGCCGTCTTAATAT
TGGGATTCTTGTGCTCTCAGTTATGGCAACTGAGGAAATGGCATTACCGTTTTGAGCTTAATGGTCAAGGAGAAGGCTGG
CTATCAACGGGAGAGGCGTTTCACGTATTGCAAAGAACTTGGGTAACGCCGTTTATCTGCTTGGTTTACTATCAATCTGC
CGATAGGTTGCATCTCTTACCTCTATGGGCGGATATGTTTAGTGATACAGATTATCGCCACTTGTGCCGGCTATTACTTA
AAGTTAAAACTCAGGCGGTGAGCCAACACGAACTACTTTAA
Antitoxin
Download Length: 84 a.a. Molecular weight: 9307.58 Da Isoelectric Point: 4.7954
>AT191582 WP_001259255.1 NZ_CP069677:1924693-1924944 [Escherichia coli O126:H45]
MRTISYSEARQNLSATMMKAVEDHAPILITRQNGEACVLMSLEEYNSLEETAYLLRSPANARRLMDSIDSLKSGKGTEKD
IIE
MRTISYSEARQNLSATMMKAVEDHAPILITRQNGEACVLMSLEEYNSLEETAYLLRSPANARRLMDSIDSLKSGKGTEKD
IIE
Download Length: 252 bp
>AT191582 NZ_CP091833:1377218-1377466 [Shewanella xiamenensis]
TTGGAGTTAATGAACATTGCACGGGTCCGTTGGGCATGTCGCCGCGGAATGCTCGAATTAGACGTTTTGTTCCAGCCCTT
CGTTGAGAATGTTTATCAGGATTTGTCTGATGAAGATAAAGCCCTGTTTATTCGTTTGCTCGAGTGTGAAGATCCTGAAT
TATTTGCATGGTTTATGGGTCATGAAGTTTGCCCTGATCCTGAGCTTGCCCGCATGATAGTGCAAGTCCGTGGCCGAGCT
GCGCCATAG
TTGGAGTTAATGAACATTGCACGGGTCCGTTGGGCATGTCGCCGCGGAATGCTCGAATTAGACGTTTTGTTCCAGCCCTT
CGTTGAGAATGTTTATCAGGATTTGTCTGATGAAGATAAAGCCCTGTTTATTCGTTTGCTCGAGTGTGAAGATCCTGAAT
TATTTGCATGGTTTATGGGTCATGAAGTTTGCCCTGATCCTGAGCTTGCCCGCATGATAGTGCAAGTCCGTGGCCGAGCT
GCGCCATAG
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|