Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | yefM-yoeB (relBE)/YoeB-YefM |
| Location | 1761739..1762241 | Replicon | chromosome |
| Accession | NZ_CP069666 | ||
| Organism | Escherichia coli O89m:H9 strain MIN11 | ||
Toxin (Protein)
| Gene name | yoeB | Uniprot ID | U9YDH0 |
| Locus tag | JSU13_RS08295 | Protein ID | WP_000767829.1 |
| Coordinates | 1761987..1762241 (+) | Length | 85 a.a. |
Antitoxin (Protein)
| Gene name | yefM | Uniprot ID | S1Q063 |
| Locus tag | JSU13_RS08290 | Protein ID | WP_001259255.1 |
| Coordinates | 1761739..1761990 (+) | Length | 84 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| JSU13_RS08265 (1756916) | 1756916..1757983 | - | 1068 | WP_000080055.1 | bifunctional histidinol-phosphatase/imidazoleglycerol-phosphate dehydratase HisB | - |
| JSU13_RS08270 (1757983) | 1757983..1759053 | - | 1071 | WP_000108933.1 | histidinol-phosphate transaminase | - |
| JSU13_RS08275 (1759050) | 1759050..1760354 | - | 1305 | WP_001352244.1 | histidinol dehydrogenase | - |
| JSU13_RS08280 (1760360) | 1760360..1761259 | - | 900 | WP_000131782.1 | ATP phosphoribosyltransferase | - |
| JSU13_RS08285 (1761405) | 1761405..1761455 | - | 51 | WP_001364200.1 | his operon leader peptide | - |
| JSU13_RS08290 (1761739) | 1761739..1761990 | + | 252 | WP_001259255.1 | YoeB-YefM toxin-antitoxin system antitoxin YefM | Antitoxin |
| JSU13_RS08295 (1761987) | 1761987..1762241 | + | 255 | WP_000767829.1 | type II toxin-antitoxin system mRNA interferase toxin YoeB | Toxin |
| JSU13_RS08300 (1762324) | 1762324..1763148 | + | 825 | WP_000754737.1 | SDR family oxidoreductase | - |
| JSU13_RS08305 (1763194) | 1763194..1764123 | + | 930 | WP_000803366.1 | LysR substrate-binding domain-containing protein | - |
| JSU13_RS08310 (1764338) | 1764338..1764400 | + | 63 | WP_010723108.1 | membrane protein YoeI | - |
| JSU13_RS08315 (1764390) | 1764390..1765748 | + | 1359 | WP_000019197.1 | putrescine/proton symporter PlaP | - |
| JSU13_RS08320 (1765927) | 1765927..1766985 | + | 1059 | WP_000492346.1 | thiosulfate utilization transporter TsuA/YeeE | - |
| JSU13_RS08325 (1766999) | 1766999..1767226 | + | 228 | WP_000985272.1 | thiosulfate utilization sulfurtransferase TsuB/YeeD | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 85 a.a. Molecular weight: 10183.58 Da Isoelectric Point: 8.0353
>T191553 WP_000767829.1 NZ_CP069666:1761987-1762241 [Escherichia coli O89m:H9]
VKLIWSEESWDDYLYWQETDKRIVKKINELIKDTRRTPFEGKGKPEPLKHNLSGFWSRRITEEHRLVYAVTDDSLLIAAC
RYHY
VKLIWSEESWDDYLYWQETDKRIVKKINELIKDTRRTPFEGKGKPEPLKHNLSGFWSRRITEEHRLVYAVTDDSLLIAAC
RYHY
Download Length: 255 bp
>T191553 NZ_CP091779:c4525534-4525349 [Enterobacter mori]
GTGAAAAGTGCGGATGTCATTACTGTTCTGATCAGCCATGGCTGGAAATGTGTCAGAACGAAAGGAAGCCATCACCAGTT
TCGCCATCCCGAACAGAAAGGGCTGGTTACTGTCCCACATCCTAAGAAGGATATTAAACCGGGCACTCTCGCCCAGATCT
GGCGGCAGGCGGGAATTAAACACTGA
GTGAAAAGTGCGGATGTCATTACTGTTCTGATCAGCCATGGCTGGAAATGTGTCAGAACGAAAGGAAGCCATCACCAGTT
TCGCCATCCCGAACAGAAAGGGCTGGTTACTGTCCCACATCCTAAGAAGGATATTAAACCGGGCACTCTCGCCCAGATCT
GGCGGCAGGCGGGAATTAAACACTGA
Antitoxin
Download Length: 84 a.a. Molecular weight: 9307.58 Da Isoelectric Point: 4.7954
>AT191553 WP_001259255.1 NZ_CP069666:1761739-1761990 [Escherichia coli O89m:H9]
MRTISYSEARQNLSATMMKAVEDHAPILITRQNGEACVLMSLEEYNSLEETAYLLRSPANARRLMDSIDSLKSGKGTEKD
IIE
MRTISYSEARQNLSATMMKAVEDHAPILITRQNGEACVLMSLEEYNSLEETAYLLRSPANARRLMDSIDSLKSGKGTEKD
IIE
Download Length: 252 bp
>AT191553 NZ_CP091779:c4525334-4524930 [Enterobacter mori]
ATGTTTTATCCGGCTTACATTCATTCTGACTCCGACGGTAGCGCCAGCGGCTTTTTCCCTGACGTTCCAGGCTGCTTTTT
TGCAGGTGATTCCCTGGACGACGCTTTTCAGGATGCACGTGATGCGCTCACATCGCACTTCGAAGCGCTGTTTGAAATGG
ATGATGCACTGCCTCTTCCGGGTAATGTGGAAGCGCATCTGGAAAGTCGTCCTGAGGATTTCACCGGCGGGCAATGGCTG
TTGGTGGATATTAATATGAAACAGTTCGACGGCAGGGCCGAGCGTATCAACATTACGATGCCTCGACGTTTGCTGGTAAA
GATTGATTCCTATGTCAGCGAGCATCCTCAGTTCGGTAATCGAAGCGCATTTCTGGCTGAGGCAGCACGTCGCGTGCTGC
CGTAG
ATGTTTTATCCGGCTTACATTCATTCTGACTCCGACGGTAGCGCCAGCGGCTTTTTCCCTGACGTTCCAGGCTGCTTTTT
TGCAGGTGATTCCCTGGACGACGCTTTTCAGGATGCACGTGATGCGCTCACATCGCACTTCGAAGCGCTGTTTGAAATGG
ATGATGCACTGCCTCTTCCGGGTAATGTGGAAGCGCATCTGGAAAGTCGTCCTGAGGATTTCACCGGCGGGCAATGGCTG
TTGGTGGATATTAATATGAAACAGTTCGACGGCAGGGCCGAGCGTATCAACATTACGATGCCTCGACGTTTGCTGGTAAA
GATTGATTCCTATGTCAGCGAGCATCCTCAGTTCGGTAATCGAAGCGCATTTCTGGCTGAGGCAGCACGTCGCGTGCTGC
CGTAG
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|