Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mqsRA (relBE)/MqsR-MqsA
Location 710567..711260 Replicon chromosome
Accession NZ_CP069666
Organism Escherichia coli O89m:H9 strain MIN11

Toxin (Protein)


Gene name mqsR Uniprot ID S1EZG2
Locus tag JSU13_RS03450 Protein ID WP_000415584.1
Coordinates 710567..710863 (+) Length 99 a.a.

Antitoxin (Protein)


Gene name mqsA Uniprot ID S1EBV2
Locus tag JSU13_RS03455 Protein ID WP_000650107.1
Coordinates 710865..711260 (+) Length 132 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JSU13_RS03415 (705655) 705655..705969 - 315 WP_000958598.1 putative quinol monooxygenase -
JSU13_RS03420 (706000) 706000..706581 - 582 WP_000065430.1 NADPH:quinone oxidoreductase MdaB -
JSU13_RS03425 (706900) 706900..707232 + 333 WP_000917685.1 DUF2645 family protein -
JSU13_RS03430 (707278) 707278..708627 - 1350 WP_000673402.1 quorum sensing histidine kinase QseC -
JSU13_RS03435 (708624) 708624..709283 - 660 WP_001221493.1 quorum sensing response regulator transcription factor QseB -
JSU13_RS03440 (709435) 709435..709827 + 393 WP_000712658.1 OB fold stress tolerance protein YgiW -
JSU13_RS03445 (709880) 709880..710362 + 483 WP_000183505.1 GyrI-like domain-containing protein -
JSU13_RS03450 (710567) 710567..710863 + 297 WP_000415584.1 type II toxin-antitoxin system toxin MqsR Toxin
JSU13_RS03455 (710865) 710865..711260 + 396 WP_000650107.1 type II toxin-antitoxin system antitoxin MqsA Antitoxin
JSU13_RS03460 (711393) 711393..713000 + 1608 WP_001295629.1 ABC transporter substrate-binding protein -
JSU13_RS03465 (713138) 713138..715396 + 2259 WP_001748758.1 DNA topoisomerase IV subunit A -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase toxin MqsR

(5-97)

Antitoxin

Zinc finger, MqsA-type

(3-47)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 11231.96 Da        Isoelectric Point: 8.9070

>T191550 WP_000415584.1 NZ_CP069666:710567-710863 [Escherichia coli O89m:H9]
MEKRTPHTRLSQVKKLVNAGQVRTTRSALLNADELGLDFDGMCNVIIGLSESDFYKSMTTYSDHTIWQDVYRPRLVTGQV
YLKITVIHDVLIVSFKEK

Download         Length: 297 bp

>T191550 NZ_CP091779:c2946680-2946327 [Enterobacter mori]
GTGTGGACAATTAATACGACGGACAGGTTTGATCGCTGGTTCACTTCGCTTGACGATACCGATCGCGCCAGCGTACTTGC
AGCAATGCTTGTTTTGCGAGAGAAGGGGCCGGGTTTATCGAGACCCTACGCCGATACGCTTAAAGGCTCTCGTCACAGCA
ACATGAAAGAGCTACGTATTCAGAGTAAGGGTGATCCATTGCGGGCGTTTTTCGCATTTGACCCAAACCGTACCGGCATC
ATGCTTTGTGCTGGCAATAAGGTCGGCAGTGAAAGGCGATTCTACGATGAGATGCTTCTCGTTGCTGATCGGGAATTCAC
TTACTGGCTGAATACATTAAAAGAGAGGGAATAG

Antitoxin


Download         Length: 132 a.a.        Molecular weight: 14703.10 Da        Isoelectric Point: 9.2136

>AT191550 WP_000650107.1 NZ_CP069666:710865-711260 [Escherichia coli O89m:H9]
MKCPVCHQGEMVSGIKDIPYTFRGRKTVLKGIHGLYCVHCEESIMNKEESDAFMAQVKAFRASVNAETVAPEFIVKVRKK
LSLTQKEASEIFGGGVNAFSRYEKGNAQPHPSTIKLLRVLDKHPELLNEIR

Download         Length: 396 bp

>AT191550 NZ_CP091779:c2946322-2946020 [Enterobacter mori]
ATGGGAAGAACCCTTGAGCAGCTTATAGCGGATGAAAAGCCGGAGGTTGTCGCCAGCGCTCAGGCGATAGCAACGGATAT
TTTGCTCAACATTCATCTGGCTGAGTTACGTGAGAAAGTACATAAAACCCAGGTAGAGATGGCACAGGCTCTGGGTATCA
GGCAGCCTACCGTTGCGGTAATGGAAAAGCCCGGGCGCGATTTGAAACTCTCTTCACTTAAGCGTTACGTTGAGGCTGCT
GGCGGAAAGCTGCGGCTTGATGTTGAACTGCCAGATGGCTCGCACTATGAGTTTGTGCTGTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 3HI2

Antitoxin

Source ID Structure
PDB 3HI2
PDB 3GA8
PDB 3O9X
PDB 2KZ8
PDB 3FMY
PDB 3GN5
AlphaFold DB A0A7U9LU65

References