Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mqsRA (relBE)/MqsR-MqsA
Location 3791559..3792252 Replicon chromosome
Accession NZ_CP069646
Organism Escherichia coli O7:H4 strain MIN14

Toxin (Protein)


Gene name mqsR Uniprot ID S1EZG2
Locus tag JSU15_RS18420 Protein ID WP_000415584.1
Coordinates 3791559..3791855 (+) Length 99 a.a.

Antitoxin (Protein)


Gene name mqsA Uniprot ID S1EBV2
Locus tag JSU15_RS18425 Protein ID WP_000650107.1
Coordinates 3791857..3792252 (+) Length 132 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JSU15_RS18385 (3786647) 3786647..3786961 - 315 WP_000958598.1 putative quinol monooxygenase -
JSU15_RS18390 (3786992) 3786992..3787573 - 582 WP_000065430.1 NADPH:quinone oxidoreductase MdaB -
JSU15_RS18395 (3787892) 3787892..3788224 + 333 WP_000917684.1 DUF2645 family protein -
JSU15_RS18400 (3788270) 3788270..3789619 - 1350 WP_000673402.1 quorum sensing histidine kinase QseC -
JSU15_RS18405 (3789616) 3789616..3790275 - 660 WP_001221493.1 quorum sensing response regulator transcription factor QseB -
JSU15_RS18410 (3790427) 3790427..3790819 + 393 WP_000712658.1 OB fold stress tolerance protein YgiW -
JSU15_RS18415 (3790872) 3790872..3791354 + 483 WP_000183505.1 GyrI-like domain-containing protein -
JSU15_RS18420 (3791559) 3791559..3791855 + 297 WP_000415584.1 type II toxin-antitoxin system toxin MqsR Toxin
JSU15_RS18425 (3791857) 3791857..3792252 + 396 WP_000650107.1 type II toxin-antitoxin system antitoxin MqsA Antitoxin
JSU15_RS18430 (3792385) 3792385..3793992 + 1608 WP_001295629.1 ABC transporter substrate-binding protein -
JSU15_RS18435 (3794130) 3794130..3796388 + 2259 WP_001281877.1 DNA topoisomerase IV subunit A -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase toxin MqsR

(5-97)

Antitoxin

Zinc finger, MqsA-type

(3-47)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 11231.96 Da        Isoelectric Point: 8.9070

>T191511 WP_000415584.1 NZ_CP069646:3791559-3791855 [Escherichia coli O7:H4]
MEKRTPHTRLSQVKKLVNAGQVRTTRSALLNADELGLDFDGMCNVIIGLSESDFYKSMTTYSDHTIWQDVYRPRLVTGQV
YLKITVIHDVLIVSFKEK

Download         Length: 297 bp

>T191511 NZ_CP091756:c4544124-4543951 [Escherichia coli]
ATGGCACTATTCTCTAAAATATTAATTTTTTATGTGATTGGTGTGAACATATCCTTTGTCATTATCTGGTTTATCTCACA
TGAGAAAACACATATTCGTTTACTTAGTGCATTCCTGGTCGGAATAACCTGGCCAATGAGTCTGCCTGTGGCATTACTTT
TTTCTCTCTTTTAG

Antitoxin


Download         Length: 132 a.a.        Molecular weight: 14703.10 Da        Isoelectric Point: 9.2136

>AT191511 WP_000650107.1 NZ_CP069646:3791857-3792252 [Escherichia coli O7:H4]
MKCPVCHQGEMVSGIKDIPYTFRGRKTVLKGIHGLYCVHCEESIMNKEESDAFMAQVKAFRASVNAETVAPEFIVKVRKK
LSLTQKEASEIFGGGVNAFSRYEKGNAQPHPSTIKLLRVLDKHPELLNEIR

Download         Length: 396 bp

>AT191511 NZ_CP091756:c4544448-4544152 [Escherichia coli]
ATGGAAGGTAAAAACAAGTTCAATACTTATGTTGTTTCTTTTGATTATCCATCATCTTATTCCTCAGTGTTCTTAAGATT
AAGATCATTGATGTATGATATGAATTTCTCCTCTATCGTGGCTGATGAATATGGGATACCACGACAATTGAATGAAAACT
CCTTCGCAATAACGACATCGTTAGCCGCAAGTGAAATCGAAGATTTAATCAGGCTCAAATGCTTAGACTTACCGGATATT
GATTTTGACCTCAACATTATGACAGTTGATGACTATTTCCGTCAGTTTTACAAGTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 3HI2

Antitoxin

Source ID Structure
PDB 3HI2
PDB 3GA8
PDB 3O9X
PDB 2KZ8
PDB 3FMY
PDB 3GN5
AlphaFold DB A0A7U9LU65

References