Detailed information of TA system TA191485

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): hok-sok/-
• Location: 3510743..3511001
• Replicon: chromosome
• Accession: NZ_CP069642
• Organism: Escherichia coli strain SSGNw2

Toxin (Protein)

• Gene name: hokC
• Uniprot ID: S1NX00
• Locus tag: JSQ95_RS16695
• Protein ID: WP_000809168.1
• Coordinates: 3510743..3510895 (-)
• Length: 51 a.a.

Antitoxin (RNA)

Gene name	sokC
Locus tag	-
Coordinates	3510944..3511001 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
JSQ95_RS16675	3505988..3506701	-	714	WP_001102391.1	acidic protein MsyB	-
JSQ95_RS16680	3506727..3507131	-	405	WP_000843687.1	DUF2541 family protein	-
JSQ95_RS16685	3507503..3509419	+	1917	WP_248414156.1	molecular chaperone DnaK	-
JSQ95_RS16690	3509508..3510638	+	1131	WP_001118465.1	molecular chaperone DnaJ	-
JSQ95_RS16695	3510743..3510895	-	153	WP_000809168.1	type I toxin-antitoxin system toxin MokC	Toxin
-	3510944..3511001	+	58	-	-	Antitoxin
JSQ95_RS16700	3511510..3512271	+	762	WP_001274832.1	outer membrane protein OmpK	-
JSQ95_RS16705	3512291..3513784	+	1494	WP_001443162.1	sulfatase-like hydrolase/transferase	-
JSQ95_RS16710	3513913..3515172	+	1260	WP_000494928.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Hok/gef cell toxic protein (6-47)

Sequences

Toxin

Protein

• Length: 51 a.a.
• Molecular weight: 5501.57 Da
• Isoelectric Point: 7.1312

>T191485 WP_000809168.1 NZ_CP069642:c3510895-3510743 [Escherichia coli]
MKQHKAMIVALIVICITAVVAALVTRKDLCEVHIRTGQTEVAVFTAYESE

Nucleotide

• Length: 153 bp

>T191485 NZ_CP091752:1965059-1965412 [Klebsiella grimontii]
GTGTGGATGATTAAAACAACGGATACGTTTGAGCGCTGGTTTACCTCGTTCAACGATACCGATAGGGCCAGCGTGCTTGC
AGCGTTGTTGGTCCTGCGAGAAAAGGGGCCGGGTTTGTCCAGACCTAATGCCGATACGCTGAGAGGCTCCCGCTACAGCA
ACATGAAAGAGTTGCGTATTCAGAGCCGGGGCGAGCCGATACGGGCATTTTTCGCTTTTGACCCGGCCCGTACCGGCATT
GTGCTTTGTGCCGGTAATAAGGTTGGCAATGAAAAACGTTTTTACGATGAGATGCTCCCTGTTGCTGAGCGGGAATTCAC
GAACTGGCTGAAGACATTCAAAGAGAAGGAGTAA

Antitoxin

Nucleotide

• Length: 58 bp

>AT191485 NZ_CP069642:3510944-3511001 [Escherichia coli]
GTTCTGCATATAGGGGGCCTCGGGTTGATGGTAAAATATCACTCGGGGCTTTTCTCTA

Structures

Toxin

• AlphaFold DB: S1NX00

Antitoxin